US4820648A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Methods for use in the mass analysis of chemical samples
Assignee: Kratos Analytical Ltd
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Filing: 1985-08-21
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Granted: 1989-04-11
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Expires: 2005-08-21
Abstract
Abstract A probe and method for using the same for supporting a sample in an ion source of a mass spectrometer comprises a target formed by a receptacle for a liquid sample in which the sample passes by diffusion to the high vacuum side of a semipermeable membrane and/or in which the sample is held as a droplet by surface tension. In order to replenish the droplet surface, the supply can be arranged to overflow the receptacle.
Inventors
- 👤 Richard M. Caprioli
- 👤 John S. Cottrell
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 17:35
CPC Classifications
H; H01; H01J; H01J49/00; H01J49/02; H01J49/04; H01J49/0431; H01J49/0436; H01J49/10; H01J49/14; H01J49/142; Y; Y10; Y10T; Y10T436/00; Y10T436/24
Claims Analysis
Total Claims: 3
Claim 1
Independent Claim
130 words
A method for the continuous analysis of a sample of a boipolymer comprising reacting a biopolymer sample in a carrier liquid with a substance which sequentially removes terminal units of the biopolymer and forms reaction products, defining a surface and locating said surface in a stationary position in a vacuum environment, causing a supply of liquid containing said reaction products to flow continuously from a high pressure region to said surface and be deposited thereon, ionising the deposited reaction products by causing a beam of particles or of radiation to impinge thereon, and mass analysing the ions produced by the ionisation thereby identifying the terminal units sequentially removed from the biopolymer by determining the reduction with time of the molecular mass of the biopolymer as the terminal units are removed.
Claim 2
Independent Claim
130 words
A method for the continuous analysis of a sample of a boipolymer comprising reacting a biopolymer sample in a carrier liquid with a substance which sequentially removes terminal units of the biopolymer and forms reaction products, defining a surface and locating said surface in a stationary position in a vacuum environment, causing a supply of liquid containing said reaction products to flow continuously from a high pressure region to said surface and be deposited thereon, ionising the deposited reaction products by causing a beam of particles or of radiation to impinge thereon, and mass analysing the ions produced by the ionisation thereby identifying the terminal units sequentially removed from the biopolymer by determining the reduction with time of the molecular mass of the biopolymer as the terminal units are removed.
Claim 3
Dependent Claim
50 words
A method according to claim 1 wherein the step of defining the surface includes providing a porous surface and wherein the step of depositing the liquid and reaction products on the surface is followed by evaporating the liquid to thereby leave a residue of reaction products on the porous surface.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-04-10 | 1992-10-10 | 1993-04-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-04-10 | 1996-10-10 | 1997-04-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-04-10 | 2000-10-10 | 2001-04-11 | $7700.00 | Window Closed / Lapsed |