US4819645A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Dermal substance collection method
Assignee: United States Department of the Army
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Filing: 1987-11-04
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Granted: 1989-04-11
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Expires: 2007-11-04
Abstract
Abstract A dermal substance collection device (DSCD) is described which provides ms for the non-invasive, instantaneous and continuous monitoring of chemical substances which are present in a detectable amount in either or both interstitial fluid or sweat or which are on or in the skin. The transdermal substance collection device of this invention is comprised of three essential components: (1) a substance binding reservoir, wettable by (2) a liquid transfer medium which allows for liquid bridge transfer of a soluble substance from the skin surface to the binding reservoir by virtue of its wettability by the liquid, and (3) an occlusive cover.
Inventors
- 👤 Carl C. Peck
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 12:28
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; A; A61; A61B; A61B10/00; A61B10/0045; A61B10/0064; A61B5/00; A61B5/42; A61B5/4261; A61B5/4283; A61B2010/0009
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
198 words
A method for the non-invasive, immediate and continuous collection of a chemical substance from a dermal surface, said method comprising the steps of I. applying to the skin to collect said chemical substance from said surface a dermal surface a dermal substance collection device (DSCD) comprised of: (a) a binding reservoir material for binding with said dermal substance to prevent back transfer loss of said dermal substance from said collection device to the dermal surfaces; (b) a liquid bridge transfer medium which allows the instantaneous and continuous transfer of said dermal substance from the dermal surface to said binding reservoir material, said binding reservoir material being maintained in a wet-state by said liquid bridge transfer medium; and (c) a cover means for occlusively containing said binding reservoir material and said liquid bridge transfer medium and for occlusively maintaining said liquid bridge transfer medium in continuous contact with the dermal surface upon application of said collection device to the dermal surface; II. maintaining the DSCD in a substantially air tight relation with the skin surface over the collection period; III. removing the binding reservoir material from the DSCD; and IV. analyzing the chemical substance collected in the binding reservoir.
Claim 2
Independent Claim
198 words
A method for the non-invasive, immediate and continuous collection of a chemical substance from a dermal surface, said method comprising the steps of I. applying to the skin to collect said chemical substance from said surface a dermal surface a dermal substance collection device (DSCD) comprised of: (a) a binding reservoir material for binding with said dermal substance to prevent back transfer loss of said dermal substance from said collection device to the dermal surfaces; (b) a liquid bridge transfer medium which allows the instantaneous and continuous transfer of said dermal substance from the dermal surface to said binding reservoir material, said binding reservoir material being maintained in a wet-state by said liquid bridge transfer medium; and (c) a cover means for occlusively containing said binding reservoir material and said liquid bridge transfer medium and for occlusively maintaining said liquid bridge transfer medium in continuous contact with the dermal surface upon application of said collection device to the dermal surface; II. maintaining the DSCD in a substantially air tight relation with the skin surface over the collection period; III. removing the binding reservoir material from the DSCD; and IV. analyzing the chemical substance collected in the binding reservoir.
Claim 3
Dependent Claim
30 words
A method according to claim 1 wherein the dermal substance collection device has a circular shape and a substantially flat profile relative to the dermal surface upon adhesive application thereto.
Claim 4
Dependent Claim
34 words
A method according to claim 1 wherein the dermal substance collection device has an immobilized liquid transfer medium approximately 1 millimeter to 7 centimeters in diameter and 1 millimeter to 0.5 centimeters in thickness.
Claim 5
Dependent Claim
16 words
A method according to claim 1 wherein the dermal substance collection device has a strippable backing.
Claim 6
Dependent Claim
14 words
A method according to claim 1 wherein said liquid bridge transfer medium is immobilized.
Claim 7
Dependent Claim
28 words
A method according to claim 5 wherein said binding reservoir is selected from the group consisting of activated charcoal, ion-exchange resin, immobilized antibody, silica, zeolite and molecular sieve.
Claim 8
Dependent Claim
32 words
A method according to claim 5 wherein said occlusive cover means is comprised of an outer adhesive layer and an inner metallic foil layer contiguous to said immobilized liquid bridge transfer medium.
Claim 9
Dependent Claim
24 words
A method according to claim 18 wherein said occlusive cover means further comprises a transfer medium-surrounding closed-cell foam layer contiguous to said foil layer.
Claim 10
Dependent Claim
40 words
A method according to claim 5 wherein said immobilized liquid bridge transfer medium comprises a protruding surface relative to the occlusive cover means and the dermal surface-interface to maintain positive pressure contact between said transfer medium and said dermal surface.
Claim 11
Dependent Claim
20 words
A method according to claim 5 wherein said binding reservoir material is dispersed in said immobilized liquid bridge transfer medium.
Claim 12
Dependent Claim
25 words
A method according to claim 10 wherein said binding reservoir material is activated charcoal and said immobilized liquid bridge transfer medium is an aqueous gel.
Claim 13
Dependent Claim
15 words
A method according to claim 11 wherein said aqueous gel comprises an osmotically active substance.
Claim 14
Dependent Claim
23 words
A method according to claim 12 wherein said aqueous gel consists essentially of an osmotically active aqueous solution and an agarose gelling agent.
Claim 15
Dependent Claim
26 words
A method according to claim 13 wherein said osmotically active aqueous solution contains sodium chloride present in an amount up to saturation of said aqueous gel.
Claim 16
Dependent Claim
39 words
A method according to claim 14 wherein the amount of agarose is 0.5 to 30% by weight of the aqueous sodium chloride solution and the amount of activated charcoal is 0.5 to 30% by weight of the aqueous gel.
Claim 17
Dependent Claim
34 words
A method according to claim 15 wherein the amount of agarose is about 3 weight-percent of the sodium chloride solution and the amount of activated charcoal is about 5 weight-percent of the aqueous gel.
Claim 18
Dependent Claim
15 words
A method according to claim 11 wherein said aqueous gel comprises an agarose gelling agent.
Claim 19
Dependent Claim
17 words
A method according to claim 11 wherein said aqueous gel comprises a polyvinyl alcohol polymer gelling agent.
Claim 20
Dependent Claim
23 words
A method according to claim 18 wherein the penetration enhancing agent is selected from the group consisting of n,n-diethyl-m-toluamide, 1-dodecylazacycloheptane-2-one, and dimethyl sulfoxide.
Claim 21
Dependent Claim
15 words
A method according to claim 7 wherein said aqueous gel comprises a penetration enhancing agent.
References Cited (Backward Citations)
US4329999A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-04-10 | 1992-10-10 | 1993-04-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-04-10 | 1996-10-10 | 1997-04-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-04-10 | 2000-10-10 | 2001-04-11 | $7700.00 | Window Closed / Lapsed |