US4818516A
Expired / Lapsed
US
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Method of nutritional assessment and therapy
Assignee: University of Oklahoma
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Filing: 1985-04-22
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Granted: 1989-04-04
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Expires: 2005-04-22
Abstract
Abstract A method for assessing nutritional status and treating a nutritional disorder in a subject. The subject's intracellular status is monitored by measuring selected intracellular amino acids and at least one intracellular metabolic process. Primary intracellular amino acids are identified for the metabolic process and the level of each is compared to normal. Treatment includes administration of a composition comprising the normal plasma concentrations of certain secondary amino acids identified for each of the abnormal primary amino acids. The cellular assessment is preferably performed on leukocytes obtained from a blood sample.
Inventors
- 👤 Jack Metcoff
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 18:04
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/5005; G01N33/5091; A; A61; A61K; A61K38/00; A61K38/01; A61K49/00; A61K49/0004
Claims Analysis
Total Claims: 37
Claim 1
Independent Claim
57 words
A method for assessing nutritional status in a subject, comprising: measuring the rate of at least one selected intracellular metabolic process; measuring the intracellular levels of selected amino acids; for each selected intracellular metabolic process, identifying the primary intracellular amino acids; and identifying each of the primary intracellular amino acids which is present at an abnormal level.
Claim 2
Independent Claim
57 words
A method for assessing nutritional status in a subject, comprising: measuring the rate of at least one selected intracellular metabolic process; measuring the intracellular levels of selected amino acids; for each selected intracellular metabolic process, identifying the primary intracellular amino acids; and identifying each of the primary intracellular amino acids which is present at an abnormal level.
Claim 3
Dependent Claim
18 words
The method of claim 1 wherein protien synthesis is measured as one of the selected intracellular metabolic processes.
Claim 4
Dependent Claim
19 words
The method of claim 2 wherein glucose metabolism and energy production are also measured as selected intracellular metabolic processes.
Claim 5
Dependent Claim
18 words
The method of claim 1 wherein energy production is measured as one of the selected intracellular metabolic processes.
Claim 6
Dependent Claim
18 words
The method of claim 1 wherein glucose metabolism is measured as one of the selected intracellular metabloic processes.
Claim 7
Dependent Claim
33 words
The method of claim 1 wherein the measuring of the selected intracellular amino acids and the selected intracellular mteabolic process are carried out on leukocytes obtained from a sample of the subject's blood.
Claim 8
Dependent Claim
20 words
The method of claim 6 in which all the measurements are made on leukocytes obtained from a single blood sample.
Claim 9
Dependent Claim
22 words
The method of claim 1 wherein multivariate statistical analysis is used to identify the normal primary amino acids in a selected population.
Claim 10
Dependent Claim
15 words
The method of claim 1 further comprising: measuring at least one non-amino acid intracellular nutrient.
Claim 11
Dependent Claim
19 words
The method of claim 9 wherein all the measurements are carried out on leukocytes from a single blood sample.
Claim 12
Independent Claim
98 words
A method for treating a subject for a nutritional disorder, comprising: measuring the intracellular levels of selected amino acids; measuring the rate of at least one selected intracellular metabolic process; for each selected intracellular metabolic process, identifying the primary intracellular amino acids; identifying wach of the primary intracellular amino acids which is present at an abnormal level; for each primary intracellular amino acid present at an abnormal level, identifying a set of secondary extracellular amino acids; and administering to the subject an effective amount of a nutrient composition comprising the identified secondary amino acids in normal extracellular concentrations.
Claim 13
Independent Claim
98 words
A method for treating a subject for a nutritional disorder, comprising: measuring the intracellular levels of selected amino acids; measuring the rate of at least one selected intracellular metabolic process; for each selected intracellular metabolic process, identifying the primary intracellular amino acids; identifying wach of the primary intracellular amino acids which is present at an abnormal level; for each primary intracellular amino acid present at an abnormal level, identifying a set of secondary extracellular amino acids; and administering to the subject an effective amount of a nutrient composition comprising the identified secondary amino acids in normal extracellular concentrations.
Claim 14
Dependent Claim
22 words
The method of claim 11 wherein the nutrient composition further comprises the indentified primary amino acids present intracellularly at below normal levels.
Claim 15
Dependent Claim
19 words
The method of claim 12 wherein glucose metabolism and energy production are also measured as selected intracellular metabolic processes.
Claim 16
Dependent Claim
19 words
The method of claim 12 wherein all the measurements are carried out on leukocytes from a single blood sample.
Claim 17
Dependent Claim
13 words
The method of claim 11 wherein the selected metabolic process is protein synthesis.
Claim 18
Dependent Claim
31 words
The method of claim 11 wherein the measurements of the selected intracellular amino acids and the selected intracellular metabolic process are carried out on leukocytes obtained from a sample of plasma.
Claim 19
Dependent Claim
20 words
The method of claim 16 in which all the measurements are made on leukocytes obtained from a single blood sample.
Claim 20
Dependent Claim
24 words
The method of claim 11 wherein multivariate statistical analysis is used to identify the normal primary and secondary amino acids in a selected population.
Claim 21
Dependent Claim
18 words
The method of claim 11 wherein energy production is measured as one of the selected intracellular metabolic processes.
Claim 22
Dependent Claim
19 words
The method of claim 11 in which glucose metabolism is measured as one of the selected intracellular metabolic processes.
Claim 23
Dependent Claim
15 words
The method of claim 11 further comprising: measuring at least one non-amino acid intracellular nutrient.
Claim 24
Dependent Claim
45 words
The method of claim 11 wherein multiple doses are administred to the subject, and wherein the rate of the selected metabolic process is repeatedly measured, and wherein the administration of the doses continues at least until the rate of the selected metabolic process approaches normal.
Claim 25
Independent Claim
125 words
A method for treating a subject for a nutritional disorder, comprising: administering to the subject an effective amount of a nutrient composition comprising normal plasma concentrations of selected secondary amino acids, wherein the secondary amino acids were selected by: measuring the intracellular levels of selected amino acids; measuring the rate of at least one selected intracellular metabolic process; for each selected intracellular metabolic proscess, identifying the primary intracellular amino acids; identifying each of the primary intracellular amino acids which is present at an abnormal level; for each primary intracellular amino acid present at an abnormal level, identifying a set of secondary amino acids; and administering to the subject an effective amount of a nutrient composition comprising the identified secondary amino acids in normal extracellular concentrations.
Claim 26
Independent Claim
125 words
A method for treating a subject for a nutritional disorder, comprising: administering to the subject an effective amount of a nutrient composition comprising normal plasma concentrations of selected secondary amino acids, wherein the secondary amino acids were selected by: measuring the intracellular levels of selected amino acids; measuring the rate of at least one selected intracellular metabolic process; for each selected intracellular metabolic proscess, identifying the primary intracellular amino acids; identifying each of the primary intracellular amino acids which is present at an abnormal level; for each primary intracellular amino acid present at an abnormal level, identifying a set of secondary amino acids; and administering to the subject an effective amount of a nutrient composition comprising the identified secondary amino acids in normal extracellular concentrations.
Claim 27
Dependent Claim
22 words
The method of claim 23 wherein the nutrient composition further comprises the identified primary amino acids present intracellularly at below normal levels.
Claim 28
Dependent Claim
19 words
The method of claim 24 wherein all the measurements are carried out on leukocytes from a single blood sample.
Claim 29
Dependent Claim
13 words
The method of claim 23 wherein the selected metabolic process is protein synthesis.
Claim 30
Dependent Claim
31 words
The method of claim 23 wherein the measurements of the selected intracellular amino acids and the selected intracellular metabolic process are carried out on leukocytes obtained from a sample of blood.
Claim 31
Dependent Claim
20 words
The method of claim 27 in which all the measurements are made on leukocytes obtained from a single blood sample.
Claim 32
Dependent Claim
24 words
The emthod of claim 23 wherein multivariate statistical analysis is used to identify the normal primary and secondary amino acids in a selected population.
Claim 33
Dependent Claim
19 words
The method of claim 29 wherein glucose metabolism and energy production are also measured as selected intracellular metabolic processes.
Claim 34
Dependent Claim
18 words
The method of claim 27 wherein energy production is measured as one of the selected intracellular metabolic processes.
Claim 35
Dependent Claim
15 words
The method of claim 31 further comprising: measuring at least one non-amino acid intracellular nutrient.
Claim 36
Dependent Claim
45 words
The method of claim 23 wherein multiple doses are administered to the subject, and wherein the rate of the selected metabloic process is repeatedly measured, and wherein the administration of the doses continues at least until the rate of the selected metabolic process approaches normal.
Claim 37
Dependent Claim
19 words
The method of claim 23 in which glucose metabolism is measured as one of the selected intracellular metabolic processes.
References Cited (Backward Citations)
US4279917A
Cited
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