US4814335A
Expired / Lapsed
US
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Antiviral compounds
Assignee: Ipsen Bioscience Inc
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Filing: 1987-06-23
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Granted: 1989-03-21
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Expires: 2007-06-23
Abstract
Abstract In one aspect, compounds having antiviral activity and having the general formula: ##STR1## wherein each R 2 , independently, is H or lower (fewer than 6 carbon atoms) alkyl; each R 3 , independently, is H or lower alkyl; R 0 is H or lower alkyl; R 1 is H or lower alkyl; 1≦n≦11; n-2≦m≦2n; 0≦p≦3; z is 0 or 1; and p≦1≦2p; each n, m, p, and q being selected so that the sp 3 valence shell of each carbon atom in each ring is filled; or a pharmaceutically acceptable salt thereof.
Inventors
- 👤 Sun H. Kim
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 17:15
CPC Classifications
C; C07; C07D; C07D239/00; C07D239/70; C07D239/72; C07D239/95; A; A61; A61P; A61P31/00; A61P31/04; A61P31/12; A61P35/00; A61P37/00
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
82 words
A compound having the formula: ##STR6## wherein X is (CH 2 ) n where 1≦n≦3, or ##STR7## where R 4 is lower alkyl; and R 3 and R 5 , independently, are H, fluoro, nitro, amino, lower alkylamino, lower dialkylamino; arylamino (wherein aryl does not include aromatic heterocycle), acylamido, carboxy, azido, lower alkoxy, trimethylsulfonyl, trifluoromethanesulfonyl, or lower alkoxycarbonyl, provided that when X is (CH 2 ) 2 , R 3 cannot be H or lower alkoxy; or a pharmaceutically acceptable salt thereof.
Claim 2
Dependent Claim
82 words
A compound having the formula: ##STR6## wherein X is (CH 2 ) n where 1≦n≦3, or ##STR7## where R 4 is lower alkyl; and R 3 and R 5 , independently, are H, fluoro, nitro, amino, lower alkylamino, lower dialkylamino; arylamino (wherein aryl does not include aromatic heterocycle), acylamido, carboxy, azido, lower alkoxy, trimethylsulfonyl, trifluoromethanesulfonyl, or lower alkoxycarbonyl, provided that when X is (CH 2 ) 2 , R 3 cannot be H or lower alkoxy; or a pharmaceutically acceptable salt thereof.
Claim 3
Dependent Claim
53 words
A compound having the formula ##STR8## wherein X is (CH 2 ) n where 1≦n≦3, or ##STR9## where R 4 is lower alkyl; and R 3 is fluoro, nitro, amino, lower alkylamino; lower dialkylamino, arylamino (wherein aryl does not include aromatic heterocycle), acylamido, carboxy, or lower alkoxycarbonyl; or a pharmaceutically acceptable salt thereof.
Claim 4
Dependent Claim
53 words
A compound having the formula ##STR8## wherein X is (CH 2 ) n where 1≦n≦3, or ##STR9## where R 4 is lower alkyl; and R 3 is fluoro, nitro, amino, lower alkylamino; lower dialkylamino, arylamino (wherein aryl does not include aromatic heterocycle), acylamido, carboxy, or lower alkoxycarbonyl; or a pharmaceutically acceptable salt thereof.
Claim 5
Dependent Claim
29 words
The compound of claim 1, wherein X is (CH 2 ) 3 , R 3 is fluoro, and R 5 is H said compound having the formula 2-amino-10-fluoro-4-oxo-5,6,7-trihydrobenzocyclohepta (6,5-d)-pyrimidine.
Claim 6
Dependent Claim
29 words
The compound of claim 1, wherein X is (CH 2 ) 3 , R 3 is nitro, and R 5 is H said compound having the formula 2-amino-10-nitro-4-oxo-5,6,7-trihydrobenzocyclohepta (6,5-d)-pyrimidine.
Claim 7
Dependent Claim
29 words
The compound of claim 1, wherein X is (CH 2 ) 3 , R 3 is amino, and R 5 is H said compound having the formula 2,10-diamino-4-oxo-5,6,7-trihydrobenzocyclohepta (6,5-d)-pyrimidine.
Claim 8
Dependent Claim
29 words
The compound of claim 1, wherein X is (CH 2 ) 3 , R 3 is azido, and R 5 is H said compound having the formula 2-amino-10-azido-4-oxo-5,6,7-trihydrobenzocyclohepta (6,5-d)-pyrimidine.
Claim 9
Dependent Claim
24 words
A biological response modifying composition comprising an effective amount of the compound of claim 1, or 2, together with a pharmaceutically acceptable carrier substance.
Claim 10
Dependent Claim
30 words
The composition of claim 7 wherein said composition is in the form of a pill, capsule, or tablet for oral administration to a human patient in need of said compound.
Claim 11
Dependent Claim
35 words
The composition of claim 7 wherein said composition is in the form of an ointment, lotion, cream, powder, gel, or spray for application to the skin of a human patient in need of said compound.
Claim 12
Dependent Claim
17 words
An anti-herpes simplex type II compound as set forth in any one of claims 1, or 2.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-03-20 | 1992-09-19 | 1993-03-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-03-20 | 1996-09-19 | 1997-03-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-03-20 | 2000-09-19 | 2001-03-21 | $7700.00 | Window Closed / Lapsed |