US4814324A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Sterol inhibitors of testosterone 5α-reductase
Assignee: Merck and Co Inc
•
Filing: 1987-03-06
•
Granted: 1989-03-21
•
Expires: 2007-03-06
Abstract
Abstract The compounds of Formula I are produced by the aerobic fermentation of a fungus of the genus GLIOCLADIUM, ATCC No. 20826. ##STR1## The compounds of Formula I are inhibitors of testosterone 5α-reductase and are useful in the treatment and prevention of acne, seborrhea, female hirsutism and benign prostatic hypertrophy.
Inventors
- 👤 Robert P. Borris
- 👤 Richard W. Burg
- 👤 Otto D. Hensens
- 👤 Leeyuan Huang
- 👤 Livia Kelemen
- 👤 Sagrario Mochales
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 08:58
CPC Classifications
C; C07; C07J; C07J71/00; C07J71/0005; Y; Y10; Y10S; Y10S435/00; Y10S435/8215; Y10S435/911
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
12 words
A compound of Formula I: ##STR4## or the pharmaceutically acceptable salts thereof.
Claim 2
Dependent Claim
12 words
A compound of Formula I: ##STR4## or the pharmaceutically acceptable salts thereof.
Claim 3
Dependent Claim
23 words
A compound according to claim 1, having the empirical formula C 34 H 52 O 10 and the NMR spectrum of FIG. 1.
Claim 4
Dependent Claim
23 words
A compound according to claim 1 having the empirical formula C 35 H 56 O 11 and the NMR spectrum of FIG. 2.
Claim 5
Dependent Claim
43 words
A process for producing a testosterone 5alpha-reductase inhibitor compound which comprises growing the strain of Gliocladium ATCC No. 20826 in an aqueous nutrient medium by aerobic fermentation of an assimilable carbon and nitrogen source and recovering therefrom a compound according to claim 1.
Claim 6
Dependent Claim
27 words
A mixture of the compounds of claim 1 produced by controlled aerobic fermentation of a fungus of the genus Gliocladium in an assimilable carbon and nitrogen source.
Claim 7
Dependent Claim
12 words
A mixture of claim 5, wherein the fungus is ATCC No. 20826.
References Cited (Backward Citations)
CA691119A
Cited
GB767422A
Cited
US3010878A
Cited
US3475275A
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US3507749A
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US3578565A
Cited
US3892629A
Cited
US4088760A
Cited
US4188379A
Cited
US4396615A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-03-20 | 1992-09-19 | 1993-03-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-03-20 | 1996-09-19 | 1997-03-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-03-20 | 2000-09-19 | 2001-03-21 | $7700.00 | Window Closed / Lapsed |