US4814181A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Dosage form comprising fast agent delivery followed by slow agent delivery
Assignee: Alza Corp
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Filing: 1987-09-03
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Granted: 1989-03-21
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Expires: 2007-09-03
Abstract
Abstract A dosage form is disclosed comprising a wall that surrounds a compartment with an exit means in the wall. The compartment comprises a first or fast releasing lamina and a second or short releasing lamina that are delivered through the exit means over two different periods of time.
Inventors
- 👤 Maureen L. Jordan
- 👤 Atul D. Ayer
- 👤 Paul R. Magruder
- 👤 David E. Edgren
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 11:14
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/20; A61K9/2072; A61K9/2086; A61K9/209; A61K9/0002; A61K9/0004
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
214 words
A method for administering a beneficial agent to an animal, said method comprising: (a) admitting into the animal dosage form comprising: (1) a wall comprising at least in part a semipermeable composition permeable to the passage of fluid and substantially impermeable to the passage of beneficial agent the wall surrounding: (2) a lumen; (3) a first lamina composition in the lumen, said first lamina composition means for forming a dispensable composition that is delivered from the dosage form in a short period of time; (4) a second lamina composition in the lumen, said second lamina composition comprising means for forming a dispensable composition that is delivered from the dosage form over a long period of time; (5) a beneficial agent in each lamina composition; (6) at least one exit means through the wall connecting the exterior of the dosage form with the lumen, said exit means sized for delivering the first dispensable composition in a short period of time; (b) imbibing fluid through the wall into each lamina composition at a rate determined by the permeability of the wall to provide fluid means for forming the dispensable composition; and (c) delivering the dispensable composition through the passageway from the dosage form to the animal for administering the beneficial agent to produce a beneficial result.
Claim 2
Independent Claim
214 words
A method for administering a beneficial agent to an animal, said method comprising: (a) admitting into the animal dosage form comprising: (1) a wall comprising at least in part a semipermeable composition permeable to the passage of fluid and substantially impermeable to the passage of beneficial agent the wall surrounding: (2) a lumen; (3) a first lamina composition in the lumen, said first lamina composition means for forming a dispensable composition that is delivered from the dosage form in a short period of time; (4) a second lamina composition in the lumen, said second lamina composition comprising means for forming a dispensable composition that is delivered from the dosage form over a long period of time; (5) a beneficial agent in each lamina composition; (6) at least one exit means through the wall connecting the exterior of the dosage form with the lumen, said exit means sized for delivering the first dispensable composition in a short period of time; (b) imbibing fluid through the wall into each lamina composition at a rate determined by the permeability of the wall to provide fluid means for forming the dispensable composition; and (c) delivering the dispensable composition through the passageway from the dosage form to the animal for administering the beneficial agent to produce a beneficial result.
Claim 3
Dependent Claim
44 words
The method for administering the beneficial agent to an animal according to claim 1, wherein the dosage form comprises an exit means through the wall connecting the lamina that is delivered over a long period of time with the exterior of the dosage form.
Claim 4
Dependent Claim
27 words
The method for administering the beneficial agent to an animal according to claim 1, wherein the short period of time is from 1 minute to 2 hours.
Claim 5
Dependent Claim
30 words
The method for administering the beneficial agent to an animal according to claim 1, wherein the long period of time is from 1 to 11/2 hours up to 24 hours.
Claim 6
Dependent Claim
21 words
The method for administering the beneficial agent to an animal according to claim 1, wherein the beneficial agent is a drug.
Claim 7
Dependent Claim
20 words
The method for administering the beneficial agent to an animal according to claim 1, wherein the animal is a human.
Claim 8
Dependent Claim
24 words
The method for administering the beneficial agent to an animal according to claim 1, wherein the dosage form is orally admitted into the animal.
Claim 9
Dependent Claim
46 words
The method for administering the beneficial agent to an animal according to claim 1, wherein the dispensable composition that is delivered in a short period of time is delivered first and the dispensable composition that is delivered over a long period of time is delivered thereafter.
Claim 10
Dependent Claim
163 words
A dosage form for delivering a beneficial agent to an environment of use, wherein the dosage form comprises: (a) a wall comprising at least in part a semipermeable composition permeable to the passage of fluid and substantially impermeable to the passage of beneficial agent, which wall surrounds and forms; (b) a compartment; (c) a first lamina composition in the compartment comprising means for delivering a beneficial agent from the dosage form in a short period of time; (d) a second lamina composition in the compartment comprising means for delivering a beneficial agent from the dosage form over a long period of time; (e) a beneficial agent selected from like and unlike beneficial agents in each lamina; and, (f) at least one exit means in the wall communicating the exterior of the dosage form with the compartment, said exit means shaped and sized for delivering said first dispensable composition in a short period of time, through the exit means to the environment of use.
Claim 11
Dependent Claim
163 words
A dosage form for delivering a beneficial agent to an environment of use, wherein the dosage form comprises: (a) a wall comprising at least in part a semipermeable composition permeable to the passage of fluid and substantially impermeable to the passage of beneficial agent, which wall surrounds and forms; (b) a compartment; (c) a first lamina composition in the compartment comprising means for delivering a beneficial agent from the dosage form in a short period of time; (d) a second lamina composition in the compartment comprising means for delivering a beneficial agent from the dosage form over a long period of time; (e) a beneficial agent selected from like and unlike beneficial agents in each lamina; and, (f) at least one exit means in the wall communicating the exterior of the dosage form with the compartment, said exit means shaped and sized for delivering said first dispensable composition in a short period of time, through the exit means to the environment of use.
Claim 12
Dependent Claim
26 words
The dosage form for delivering the beneficial agent to the environment of use according to claim 9, wherein the environment of use is a warm-blooded animal.
Claim 13
Dependent Claim
25 words
The dosage form for delivering the beneficial agent to the environment of use according to claim 9, wherein the environment of use is a human.
Claim 14
Dependent Claim
37 words
The dosage form for delivering the beneficial agent to the environment of use according to claim 9, wherein the environment of use is a gastrointestinal tract and the dosage form is orally admitted into the gastrointestinal tract.
Claim 15
Dependent Claim
33 words
The dosage form for delivering the beneficial agent to the environment of use according to claim 9, wherein the beneficial agent is a drug and the dosage form is a drug administration device.
Claim 16
Dependent Claim
53 words
The dosage form for delivering the beneficial agent to the environment of use according to claim 9, wherein the first lamina composition that is delivered in a short period of time comprises a gel composition, and the second lamina composition that is delivered in a long period time comprises a different gel composition.
Claim 17
Dependent Claim
54 words
The dosage form for delivering the beneficial agent to the environment of use according to claim 9, where the first lamina composition that is delivered in a short period of time comprises a cellulosic composition, and the second lamina composition that is delivered in a long period of time comprises a different cellulosic composition.
Claim 18
Dependent Claim
25 words
The dosage form for delivering the beneficial agent to the environment of use according to claim 9, wherein the exit means is longer than wide.
Claim 19
Dependent Claim
49 words
The dosage form for delivering the beneficial agent to the environment of use according to claim 9, wherein the first lamina composition that is delivered in a short period of time is initially in contact with the second lamina composition that is delivered in a long period of time.
Claim 20
Dependent Claim
48 words
The dosage form for delivering the beneficial agent to the environment of use according to claim 9, wherein the first lamina composition lamina that is delivered in a short period of time is parallel with the second lamina composition that is delivered in a long period of time.
Claim 21
Dependent Claim
47 words
The dosage form for delivering the beneficial agent to the environment of use according to claim 9, wherein the second lamina composition that is delivered in a long period of time is thicker than the first lamina composition that is delivered in a short period of time.
Claim 22
Dependent Claim
60 words
The dosage form for delivering the beneficial agent to the environment of use according to claim 9, wherein the second lamina composition that is delivered in a long period of time comprises at least one polymeric member exhibiting a larger molecular weight than a polymeric member in the first lamina composition that is delivered in a short period of time.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-03-20 | 1992-09-19 | 1993-03-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-03-20 | 1996-09-19 | 1997-03-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-03-20 | 2000-09-19 | 2001-03-21 | $7700.00 | Window Closed / Lapsed |