US4810394A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Process and apparatus for removing solid material including blood cells from whole blood
Assignee: Fujifilm Holdings Corp
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Filing: 1987-09-02
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Granted: 1989-03-07
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Expires: 2007-09-02
Abstract
Abstract An instrument for separation of liquid from solid material comprising: a volume filtration layer having a void volume of not less than 90% which is composed of fibrous material; and a pressure-resistant housing having a liquid entrance and a liquid exit which encases said volume filtration layer therein in such a manner that the side face of the volume filtration layer is tightly arranged in contact with an inner face of the housing so as to prevent passage of the solid material along the interface between the side face of the volume filtration layer and the inner face of the housing.
Inventors
- 👤 Nobuhito Masuda
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 15:02
CPC Classifications
B; B01; B01D; B01D24/00; Y; Y10; Y10T; Y10T436/00; Y10T436/25; Y10T436/25375
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
208 words
A process for removing solid material including blood cells from whole blood to obtain plasma, utilizing an instrument comprising a volume filtration layer and a solid-material-trapping porous layer encased in a pressure-resistant housing, said volume filtration layer having a void volume of not less than 90% and being essentially composed of fibrous material having fiber thickness in the range of 0.1 to 5 μm and fiber length in the range of 100 to 4,000 μm, said solid-material-trapping porous layer being of fibrous material or a blushed polymer and being provided in contact with the surface of the volume filtration layer, said pressure-resistant housing having a liquid entrance and a liquid exit and encasing said volume filtration layer and said solid-material-trapping layer in such manner that side faces of the volume filtration layer and the solid material-trapping layer are arranged in tight contact with an inner face of the housing, said process comprising the steps of: supplying the whole blood onto the surface of the volume filtration layer through the liquid entrance of the housing to trap the solid material of the whole blood within the volume of the layer and on the surface of the solid-material-trapping layer; and recovering the plasma from the liquid exit of the housing.
Claim 2
Dependent Claim
208 words
A process for removing solid material including blood cells from whole blood to obtain plasma, utilizing an instrument comprising a volume filtration layer and a solid-material-trapping porous layer encased in a pressure-resistant housing, said volume filtration layer having a void volume of not less than 90% and being essentially composed of fibrous material having fiber thickness in the range of 0.1 to 5 μm and fiber length in the range of 100 to 4,000 μm, said solid-material-trapping porous layer being of fibrous material or a blushed polymer and being provided in contact with the surface of the volume filtration layer, said pressure-resistant housing having a liquid entrance and a liquid exit and encasing said volume filtration layer and said solid-material-trapping layer in such manner that side faces of the volume filtration layer and the solid material-trapping layer are arranged in tight contact with an inner face of the housing, said process comprising the steps of: supplying the whole blood onto the surface of the volume filtration layer through the liquid entrance of the housing to trap the solid material of the whole blood within the volume of the layer and on the surface of the solid-material-trapping layer; and recovering the plasma from the liquid exit of the housing.
Claim 3
Dependent Claim
24 words
The process as claimed in claim 1, wherein the void volume of the volume filtration layer is in the range of 95 to 98%.
Claim 4
Dependent Claim
24 words
The process as claimed in claim 1, wherein the void volume of the solid material-trapping layer is in the range of 65 to 95%.
Claim 5
Dependent Claim
22 words
The process as claimed in claim 1, wherein the volume filtration layer has a density of 0.02 to 0.15 g/cm 3 .
Claim 6
Dependent Claim
22 words
The process as claimed in claim 1, wherein the volume filtration layer has a density of 0.04 to 0.08 g/cm 3 .
Claim 7
Dependent Claim
28 words
The process as claimed in claim 1, wherein the solid-material-trapping layer is essentially composed of glass fibers and having a density of 0.1 to 0.5 g/cm 3 .
Claim 8
Dependent Claim
37 words
The instrument as claimed in claim 1, wherein the volume filtration layer is essentially composed of a fibrous material selected from the group consisting of glass fibers, natural organic fibers, semi-synthetic organic fibers or synthetic organic fibers.
Claim 9
Dependent Claim
37 words
The instrument as claimed in claim 1, wherein the solid-material-trapping layer is made of a fibrous material selected from the group consisting of glass fibers, natural organic fibers, semi-synthetic organic fibers, synthetic organic fibers or blushed polymer.
Claim 10
Dependent Claim
190 words
An instrument for removing solid material including blood cells from whole blood to obtain plasma comprising: means including a volume filtration layer having a void volume of not less than 90% which is essentially composed of fibrous material having fiber thickness in the range of 0.5 μm and fiber length in the range of 100 to 4,000 μm for receiving said blood and trapping said solid material within its volume; means including a porous solid-material-trapping layer of a material selected from the group consisting of fibrous material and blushed polymer, provided in contact with the surface of the volume filtration layer, for receiving solid material from said volume filtration layer and trapping said solid material by surface filtration thereof; and a pressure-resistant housing having a liquid entrance and a liquid exit which encases said volume filtration layer and said solid-material-trapping layer, wherein side faces of the volume filtration layer and the solid-material-trapping layer are arranged in contact with an inner face of the housing so as to prevent passage of the solid material along the interface between the side faces of both layers and the inner face of the housing.
Claim 11
Dependent Claim
190 words
An instrument for removing solid material including blood cells from whole blood to obtain plasma comprising: means including a volume filtration layer having a void volume of not less than 90% which is essentially composed of fibrous material having fiber thickness in the range of 0.5 μm and fiber length in the range of 100 to 4,000 μm for receiving said blood and trapping said solid material within its volume; means including a porous solid-material-trapping layer of a material selected from the group consisting of fibrous material and blushed polymer, provided in contact with the surface of the volume filtration layer, for receiving solid material from said volume filtration layer and trapping said solid material by surface filtration thereof; and a pressure-resistant housing having a liquid entrance and a liquid exit which encases said volume filtration layer and said solid-material-trapping layer, wherein side faces of the volume filtration layer and the solid-material-trapping layer are arranged in contact with an inner face of the housing so as to prevent passage of the solid material along the interface between the side faces of both layers and the inner face of the housing.
Claim 12
Dependent Claim
24 words
The instrument as claimed in claim 9, wherein the void volume of the volume filtration layer is in the range of 95 to 98%.
Claim 13
Dependent Claim
24 words
The instrument as claimed in claim 9, wherein the void volume of the solid material-trapping layer is in the range of 65 to 95%.
Claim 14
Dependent Claim
22 words
The instrument as claimed in claim 9, wherein the volume filtration layer has a density of 0.02 to 0.15 g/cm 3 .
Claim 15
Dependent Claim
22 words
The instrument as claimed in claim 9, wherein the volume filtration layer has a density of 0.04 to 0.08 g/cm 3 .
Claim 16
Dependent Claim
29 words
The instrument as claimed in claim 9, wherein the solid material-trapping layer is essentially composed of glass fibers and having a density of 0.1 to 0.5 g/cm 3 .
Claim 17
Dependent Claim
37 words
The instrument as claimed in claim 9, wherein the volume filtration layer is essentially composed of a fibrous material selected from the group consisting of glass fibers, natural organic fibers, semi-synthetic organic fibers, or synthetic organic fibers.
Claim 18
Dependent Claim
37 words
The instrument as claimed in claim 9, wherein the solid-material-trapping layer is made of a fibrous material selected from the group consisting of glass fibers, natural organic fibers, semi-synthetic organic fibers, synthetic organic fibers or blushed polymer.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-03-06 | 1992-09-05 | 1993-03-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-03-06 | 1996-09-05 | 1997-03-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-03-06 | 2000-09-05 | 2001-03-07 | $7700.00 | Window Closed / Lapsed |