US4808716A
Expired / Lapsed
US
⏱️ 0.0 years remaining
9-(phosponylmethoxyalkyl) adenines, the method of preparation and utilization thereof
Assignee: Czech Academy of Sciences
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Filing: 1986-04-25
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Granted: 1989-02-28
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Expires: 2006-04-25
Abstract
Abstract The invention relates to 9-(phosphonylmethoxyalkyl)adenines of the general formula I <IMAGE> (I) wherein R1 is a hydrogen atom, and alkyl group containing one to three carbon atoms, or a hydroxymethyl group, R2 is a methylene, ethylene, propylene, ethylidene, methoxyethylene, benzyloxyethylene, tetrahydropyran-2-yloxyethylene, (1-ethoxyethoxy)ethylene or 1,2-O-isopropylidene-1,2-dihydroxypropylene group the method of their preparation and utilization. Compounds of the general formula I exhibit biological effects (e.g. antiviral) or can be converted into compounds with such effects.
Inventors
- 👤 Antonin Holy
- 👤 Ivan Rosenberg
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 14:16
CPC Classifications
C; C07; C07F; C07F9/00; C07F9/02; C07F9/547; C07F9/6561; C07F9/65616; A; A61; A61P; A61P31/00; A61P31/12
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
37 words
A 9-(phosphonylmethoxyalkyl)adenine having the formula I ##STR10## wherein R 1 is hydrogen and R 2 is selected from the group consisting of methylene, ethylene, propylene, ethylidene, and 1,2-O-isopropylidene-1,2-di-hydroxypropylene; and the salts thereof with alkali metals or ammonia.
Claim 2
Dependent Claim
37 words
A 9-(phosphonylmethoxyalkyl)adenine having the formula I ##STR10## wherein R 1 is hydrogen and R 2 is selected from the group consisting of methylene, ethylene, propylene, ethylidene, and 1,2-O-isopropylidene-1,2-di-hydroxypropylene; and the salts thereof with alkali metals or ammonia.
Claim 3
Dependent Claim
48 words
A 9-(phosphonylmethoxyalkyl)adenine of the formula ##STR11## wherein R 1 is selected from the group consisting of methyl and hydroxymethyl and R 2 is selected from the group consisting of methylene, ethylene, propylene, ethylidene, methoxyethylene, benzyloxyethylene, tetrahydropyranyl-2-oxyethylene, (1-ethoxyethoxy)ethylene and 1,2-O-isopropylidene-1,2-dihydroxypropylene; and the salts thereof with alkali metals or ammonia.
Claim 4
Dependent Claim
48 words
A 9-(phosphonylmethoxyalkyl)adenine of the formula ##STR11## wherein R 1 is selected from the group consisting of methyl and hydroxymethyl and R 2 is selected from the group consisting of methylene, ethylene, propylene, ethylidene, methoxyethylene, benzyloxyethylene, tetrahydropyranyl-2-oxyethylene, (1-ethoxyethoxy)ethylene and 1,2-O-isopropylidene-1,2-dihydroxypropylene; and the salts thereof with alkali metals or ammonia.
References Cited (Backward Citations)
US4323573A
Cited
BE898620A
Cited
FR2539132A1
Cited
DE3400278A1
Cited
US4659825A
Cited
WO1984004748A2
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-02-28 | 1992-08-29 | 1993-02-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-02-28 | 1996-08-29 | 1997-02-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-02-28 | 2000-08-29 | 2001-02-28 | $7700.00 | Window Closed / Lapsed |