US4797479A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Nucleoside-phospholipid conjugate
Assignee: Asahi Kasei Corp
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Filing: 1986-04-15
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Granted: 1989-01-10
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Expires: 2006-04-15
Abstract
Abstract A compound of the formula <IMAGE> wherein R1 and R2 are long-chain fatty acid residue, and Ns is nucleoside residue selected from the group consisting of 5-fluorouridine-5'-yl, 5-fluoro-2'-deoxyuridine-5'-yl-, bredinin-5'-yl, tubercidine-5'-yl-, neplanocin A-6'-yl-, 5-fluorocytidine-5'-yl-, arabinosylcytosine-5'-yl, arabinocyl-5-fluorocytosine-5'-yl-, arabinosyladenine-5'-yl- and arabinosylthymine-5 '-yl-, and pharmacologically acceptable salts thereof, having antitumor activity.
Inventors
- 👤 Satoshi Shuto
- 👤 Hiromichi Ito
- 👤 Kiyofumi Fukukawa
- 👤 Hideo Sakakibara
- 👤 Masatoshi Tsujino
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:54
CPC Classifications
C; C07; C07D; C07D473/00; C07D473/26; C07D473/32; C07D473/34; C07H; C07H19/00; C07H19/02; C07H19/04; C07H19/052; C07H19/06; C07H19/10; C07H19/16; C07H19/20; C07H19/207
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
40 words
A compound of the formula ##STR10## wherein R 1 and R 2 are long-chain fatty acid residue, and Ns is neplanocin A-6'-yl- or a nucleoside residue selected from the group consisting of 5-fluorouridine-5'-yl, and arabinocyl-5-fluorocytosine-5'-yl-, and pharmacologically acceptable salts thereof.
Claim 2
Dependent Claim
40 words
A compound of the formula ##STR10## wherein R 1 and R 2 are long-chain fatty acid residue, and Ns is neplanocin A-6'-yl- or a nucleoside residue selected from the group consisting of 5-fluorouridine-5'-yl, and arabinocyl-5-fluorocytosine-5'-yl-, and pharmacologically acceptable salts thereof.
Claim 3
Dependent Claim
23 words
Compound according to claim 1 wherein R 1 and R 2 are palmitoyl and Ns is 5-fluorouridine-5'-yl- or a pharmocologically acceptable salt thereof.
Claim 4
Dependent Claim
24 words
Compound according to claim 1 wherein R 1 and R 2 are palmitoyl and Ns is neplanocin A-6'-yl- or a pharmacologically acceptable salt thereof.
Claim 5
Dependent Claim
23 words
Compound according to claim 1 wherein R 1 and R 2 are stearoyl, and Ns is 5-fluorouridine-5'-yl- or a pharmacologically acceptable salt thereof.
Claim 6
Dependent Claim
24 words
Compound according to claim 1 wherein R 1 and R 2 are stearoyl, and Ns is neplanocin A-6'-yl- or a pharmacologically acceptable salt thereof.
References Cited (Backward Citations)
US4291024A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-01-10 | 1992-07-11 | 1993-01-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-01-10 | 1996-07-11 | 1997-01-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-01-10 | 2000-07-11 | 2001-01-10 | $7700.00 | Window Closed / Lapsed |