US4795741A
Expired / Lapsed
US
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Compositions for therapeutic percutaneous embolization and the use thereof
Assignee: Sanofi Biosurgery Inc
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Filing: 1987-05-06
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Granted: 1989-01-03
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Expires: 2007-05-06
Abstract
Abstract Percutaneous emboli are formed for therapeutic and/or corrective reasons by using a composition which includes crosslinked gells of hyaluronic acid (HA), hylan (HY) or mixed crosslinked gels of HA or HY with other materials, thrombin and cationic substances containing quaternary ammonium groups. Other optional materials include fillers and radio-opaque substances.
Inventors
- 👤 Adolf Leshchiner
- 👤 Nancy E. Larsen
- 👤 Endre A. Balazs
- 👤 Sadek K. Hilal
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 14:38
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K47/00; A61K47/30; A61K47/36; A61K49/00; A61K49/04; A61L; A61L24/00; A61L24/0047; A61L24/0073; A61L24/04; A61L24/08; A61L2430/00; A61L2430/36
Claims Analysis
Total Claims: 30
Claim 1
Independent Claim
62 words
A composition for effecting embolization in blood vessels which comprises a physical mixture of (a) a first component which is a cross-linked gel of hyaluronic acid, a cross-linked gel of hylan, or a mixed gel of hyaluronic acid or hylan co-cross-linked with at least one other hydrophilic polymer copolymerizable therewith; (b) a cationic organic substance containing quaternary ammonium groups; and (c) thrombin.
Claim 2
Dependent Claim
62 words
A composition for effecting embolization in blood vessels which comprises a physical mixture of (a) a first component which is a cross-linked gel of hyaluronic acid, a cross-linked gel of hylan, or a mixed gel of hyaluronic acid or hylan co-cross-linked with at least one other hydrophilic polymer copolymerizable therewith; (b) a cationic organic substance containing quaternary ammonium groups; and (c) thrombin.
Claim 3
Dependent Claim
60 words
A composition according to claim 1 wherein said at least one other hydrophilic polymer is a natural or synthetic polysaccharide selected from the group consisting of hydroxyethyl cellulose, carboxymethyl cellulose, xanthan gum, chondroitin sulfate and heparin, a protein selected from the group consisting of collagen, elastin, albumin, a globulin, keratin sulfate, a sulfated aminoglycosaminoglycan and a synthetic water soluble polymer.
Claim 4
Dependent Claim
53 words
A composition according to claim 1 wherein the cationic organic substance containing quaternary ammonium groups is a monomeric compound containing at least one cationic group selected from the group consisting of choline chloride, acetylcholine chloride and N,N,N,N',N',N'-hexamethyl - 1,6-diaminium bromide, hexadimethrine bromide or a soluble high molecular weight polymer containing quaternary ammonium groups.
Claim 5
Dependent Claim
12 words
A composition according to claim 1 wherein the thrombin is human thrombin.
Claim 6
Dependent Claim
64 words
A composition according to claim 1 wherein the first component has an apparent viscosity η at a shear rate (γ=0.01s -1 ) of from 10 to several thousands Pa.s; a dynamic storage modulus at 5 Hz of from 10 to 100 Pa; a dynamic loss modulus at 5 Hz of from 5 to 20 Pa; and a pseudoplasticity of from 10 to several thousands.
Claim 7
Dependent Claim
13 words
A composition according to claim 1 and further comprising a water insoluble filler.
Claim 8
Dependent Claim
19 words
A composition according to claim 6 wherein the water insoluble filler is a hydrophilic, hydrophobic, organic or inorganic material.
Claim 9
Dependent Claim
13 words
A composition according to claim 7 wherein the filler is an inorganic material.
Claim 10
Dependent Claim
18 words
A composition according to claim 8 wherein the inorganic material is a metal powder or an insoluble salt.
Claim 11
Dependent Claim
13 words
A composition according to claim 9 wherein the insoluble salt is barium sulfate.
Claim 12
Dependent Claim
13 words
A composition according to claim 7 wherein the filler is an organic material.
Claim 13
Dependent Claim
23 words
A composition according to claim 11 wherein the organic material is microcrystalline cellulose, polyethylene, polytetrafluoroethylene, cross-linked hyaluronic acid, agarose or an ion-exchange resin.
Claim 14
Dependent Claim
12 words
A composition according to claim 1 and further comprising a radio-opaque substance.
Claim 15
Dependent Claim
25 words
A composition according to claim 13 wherein the radio-opaque substance is an inorganic filler selected from the group consisting of powdered tantalum and barium sulfate.
Claim 16
Dependent Claim
15 words
A composition according to claim 13 wherein the radio-opaque substance is an iodinated organic substance.
Claim 17
Dependent Claim
18 words
A composition according to claim 15 wherein the iodinated organic substance is sodium iothalamate, sodium metrizoate or metrizamide.
Claim 18
Dependent Claim
39 words
A composition according to claim 1 wherein the cationic organic substance comprises from 0.1 to 20% by weight of the total weight and the composition contains from 0.5 to 1000 NIH units of thrombin per gram of the composition.
Claim 19
Dependent Claim
18 words
A composition according to claim 17 wherein the cationic organic substance comprises from 0.2 to 10% by weight.
Claim 20
Dependent Claim
18 words
A composition according to claim 18 wherein the cationic organic substance comprises from 1 to 5% by weight.
Claim 21
Dependent Claim
25 words
A composition according to claim 6 wherein the water insoluble filler comprises from 1 to 60% by weight of the total weight of the composition.
Claim 22
Dependent Claim
18 words
A composition according to claim 20 wherein the water insoluble filler comprises from 2 to 30% by weight.
Claim 23
Dependent Claim
18 words
A composition according to claim 21 wherein the water insoluble filler comprises from 5 to 25% by weight.
Claim 24
Dependent Claim
24 words
A composition according to claim 13 wherein the radio-opaque substance comprises from 2 to 30% by weight of the total weight of the composition.
Claim 25
Dependent Claim
17 words
A composition according to claim 23 wherein the radio-opaque substance comprises from 4 to 20% by weight.
Claim 26
Dependent Claim
17 words
A composition according to claim 24 wherein the radio-opaque substance comprises from 5 to 15% by weight.
Claim 27
Dependent Claim
12 words
A composition according to claim 1 and further comprising a fluorescent substance.
Claim 28
Dependent Claim
29 words
A method for producing a therapeutic embolus in vivo in an animal comprising intraarterially injecting into an animal an effective amount of a composition as claimed in claim 1.
Claim 29
Dependent Claim
45 words
A method for treating a tumor comprising producing an embolus in accordance with the method according to claim 26 at a point upstream of where an artery enters the tumor to be treated, thereby depriving the tumor of nutrients otherwise supplied thereto by said artery.
Claim 30
Dependent Claim
30 words
A drug delivery system comprising a composition according to claim 1 and an effective amount of a drug to be delivered from an embolus formed in vivo from the composition.
References Cited (Backward Citations)
US4582865A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-01-03 | 1992-07-04 | 1993-01-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-01-03 | 1996-07-04 | 1997-01-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-01-03 | 2000-07-04 | 2001-01-03 | $7700.00 | Window Closed / Lapsed |