US4794150A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Synthesis of peptide analogs
Assignee: EDWIN D SCHINDLER 1523 EAST 4TH STREET BROOKLYN NEW YORK 11230
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Filing: 1987-03-11
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Granted: 1988-12-27
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Expires: 2007-03-11
Abstract
Abstract A novel polymeric disc, wafer or similarly shaped resin for carrying out the synthsis of peptide analogs via solid phase peptide synthesis techniques is provided. The polymeric disc or wafer of the invention may be made out of those resin materials presently used in bead form in solid phase peptide synthesis, such as, benzhydrylamine resins, Boc-aminoacyl-4-(oxymethyl)-phenyacetamidomethyl (Pam) resin, polyamide resins and chloromethyl resins. The disc or wafer of the invention should, preferably, have a thickness of 200-400 μm and may be of any suitable length or width. A process for the synthsis of peptide analogs utilizing the polymeric disc or wafer of the present invention is also disclosed.
Inventors
- 👤 Samuel Steel
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 23:28
CPC Classifications
C; C07; C07K; C07K1/00; C07K1/04; C07K1/045; B; B01; B01J; B01J2219/00; B01J2219/00274; B01J2219/00277; B01J2219/00497; B01J2219/00527; B01J2219/00536; B01J2219/00583; B01J2219/0059; B01J2219/00596; B01J2219/00603; B01J2219/00605; B01J2219/0061; B01J2219/00623; B01J2219/00626; B01J2219/00718; B01J2219/0072; B01J2219/00725; C40; C40B; C40B40/00; C40B40/04; C40B40/10
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
83 words
A polymeric resin for use in a solid phase peptide synthesis of peptide analogs, said resin being insoluble and capable of permitting an attachment to it of a first amino acid in said solid phase peptide synthesis, wherein the improvement comprises said resin being in a shape of a water or a disc and reactor cell means for use in combination with said resin, said reactor cell means being capable of at least partially containing said resin during said solid phase peptide synthesis.
Claim 2
Dependent Claim
83 words
A polymeric resin for use in a solid phase peptide synthesis of peptide analogs, said resin being insoluble and capable of permitting an attachment to it of a first amino acid in said solid phase peptide synthesis, wherein the improvement comprises said resin being in a shape of a water or a disc and reactor cell means for use in combination with said resin, said reactor cell means being capable of at least partially containing said resin during said solid phase peptide synthesis.
Claim 3
Dependent Claim
16 words
The polymeric resin according to claim 1, wherein said resin has a thickness of 200-400 μm.
Claim 4
Dependent Claim
36 words
The polymeric resin according to claim 1, wherein said resin is made of a member selected from the group consisting of a benzhydrylamine, Boc-aminoacyl-4-(oxymethyl)-phenylacetamido-methyl polyamide, cross-linked polystyrene, p-hydroxymethyl, hydrazide, ether, p-alkoxybenzyl alcohol and a combination thereof.
Claim 5
Dependent Claim
15 words
The polymeric resin according to claim 1, wherein the shape of said resin is circular.
Claim 6
Dependent Claim
19 words
The polymeric resin according to claim 1, wherein the shape of said resin includes at least one straight edge.
Claim 7
Dependent Claim
12 words
The polymeric resin according to claim 1, further comprising an inert support.
Claim 8
Dependent Claim
14 words
The polymeric resin according to claim 6, wherein said inert support is a nylon.
Claim 9
Dependent Claim
39 words
The polymeric resin according to claim 1, further comprising an inert support which is capable of permitting the transfer of said polymeric resin from a first reaction vessel to a second reaction vessel by means of a tongs instrument.
Claim 10
Dependent Claim
150 words
A process for the synthesis of peptide analogs, comprising the steps of: (a) tagging a set of polymeric resin discs or wafers for use in a solid phase peptide synthesis of said peptide analogs so that each of said polymeric resin discs of wafers is designated for the synthesis of one or more of said peptide analogs; (b) placing said polymeric resin discs or wafers into at least one reaction vessel having reagents for the solid phase peptide synthesis of an amino acid sequence of said peptide analogs wherein said amino acid sequence of said peptide analogs is to be common to said peptide analogs being synthesized; and (c) placing said polymeric resin discs or wafers into separate reaction vessels having reagents for said solid phase peptide synthesis of amino acid sequences of said peptide analogs which are not to be common to all of said peptide analogs being synthesized.
Claim 11
Dependent Claim
150 words
A process for the synthesis of peptide analogs, comprising the steps of: (a) tagging a set of polymeric resin discs or wafers for use in a solid phase peptide synthesis of said peptide analogs so that each of said polymeric resin discs of wafers is designated for the synthesis of one or more of said peptide analogs; (b) placing said polymeric resin discs or wafers into at least one reaction vessel having reagents for the solid phase peptide synthesis of an amino acid sequence of said peptide analogs wherein said amino acid sequence of said peptide analogs is to be common to said peptide analogs being synthesized; and (c) placing said polymeric resin discs or wafers into separate reaction vessels having reagents for said solid phase peptide synthesis of amino acid sequences of said peptide analogs which are not to be common to all of said peptide analogs being synthesized.
Claim 12
Dependent Claim
16 words
The process according to claim 9 wherein said step (b) is carried out with conventional tongs.
Claim 13
Dependent Claim
16 words
The process according to claim 9 wherein said step (c) is carried out with conventional tongs.
Claim 14
Dependent Claim
17 words
The process according to claim 9, wherein said step (b) is carried out with one reaction vessel.
Claim 15
Dependent Claim
33 words
The process according to claim 9, wherein the number of said reaction vessels employed in step (c) is at least one greater than the number of said reaction vessles employed in step (b).
Claim 16
Dependent Claim
24 words
The process according to claim 9, wherein said separate reaction vessels are capable of being a single reaction vessel at differing points in time.
Claim 17
Dependent Claim
19 words
The process according to claim 9, wherein said polymeric resin discs or wafers have a thickness of 200-400 μm.
Claim 18
Dependent Claim
39 words
The process according to claim 9, wherein said polymeric resin discs or wafers are made of a member selected from the group consisting of a benzhydrylamine. Boc-aminoacyl-4-(oxymethyl)-phenylacetamido-methyl, polyamide, cross-linked polystyrene, p-hydroxymethyl, hydrazide, ether, p-alkoxybenzyl alcohol and a combination thereof.
Claim 19
Dependent Claim
21 words
The process according to claim 9, wherein at least one of said polymeric resin discs or wafers are circular in shape.
Claim 20
Dependent Claim
23 words
The process according to claim 9, wherein at least one of said polymeric resin discs or wafers have at least one straight edge.
Claim 21
Dependent Claim
17 words
The process according to claim 9, wherein said polymeric resin discs or wafers include an inert support.
Claim 22
Dependent Claim
13 words
The process according to claim 19, wherein said inert support is a nylon.
Claim 23
Dependent Claim
47 words
The process according to claim 19, wherein said polymeric resin discs or wafers include an inert support which is capable of permitting a transfer of said polymeric resin discs or wafers from a first reaction vessel to a second reaction vessel by means of a tongs instrument.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-12-27 | 1992-06-27 | 1992-12-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-12-27 | 1996-06-27 | 1996-12-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-12-27 | 2000-06-27 | 2000-12-27 | $7700.00 | Window Closed / Lapsed |