US4792448A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Generic zero order controlled drug delivery system
Assignee: Pfizer Inc
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Filing: 1987-06-11
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Granted: 1988-12-20
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Expires: 2007-06-11
Abstract
Abstract A device for zero order releasing of biologically active substances into a fluid medium comprising a cylindrical tablet or bolus covered with an impermeable wall or coating from which strips of said wall or coating have been removed.
Inventors
- 👤 Gautam R. Ranade
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 01:42
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0053; A61K9/0068; A61K9/20; A61K9/2072; A61L; A61L9/00; A61L9/015; A61L9/04; A61L9/05
Claims Analysis
Total Claims: 35
Claim 1
Independent Claim
74 words
A device for the controlled release of one or more active substances into a fluid medium at a substantially constant rate which comprises said substance homogeneously dispersed, with or without one or more inert excipients, and contained substantially in the shape of a cylindrical tablet or bolus by means of an all-covering essentially impermeable wall or coating except for one or more strips of removed wall or coating from the side of said device.
Claim 2
Independent Claim
74 words
A device for the controlled release of one or more active substances into a fluid medium at a substantially constant rate which comprises said substance homogeneously dispersed, with or without one or more inert excipients, and contained substantially in the shape of a cylindrical tablet or bolus by means of an all-covering essentially impermeable wall or coating except for one or more strips of removed wall or coating from the side of said device.
Claim 3
Dependent Claim
17 words
A device of claim 1, wherein the side is flat and the top and bottom are convex.
Claim 4
Dependent Claim
22 words
A device of claim 2, wherein more than one strip of wall or coating is removed from the side of said device.
Claim 5
Dependent Claim
21 words
A device of claim 3, wherein the width of said removed strips can be the same or different from each other.
Claim 6
Dependent Claim
16 words
A device of claim 4, wherein the device is in the shape of a cylindrical tablet.
Claim 7
Dependent Claim
15 words
A device of claim 4, wherein the device is in the shape of a bolus.
Claim 8
Dependent Claim
11 words
A device of claim 1, wherein the substance is biologically active.
Claim 9
Dependent Claim
21 words
A device of claim 7, wherein the activity is to prevent or reduce odors in or emanating from the fluid medium.
Claim 10
Dependent Claim
11 words
A device of claim 7, wherein the substance has germicidal activity.
Claim 11
Dependent Claim
11 words
A device of claim 7, wherein the substance has pharmacological activity.
Claim 12
Dependent Claim
90 words
A bolus for oral administration into the reticulum or rumen of a ruminant mammal, said bolus being retained in said rumen or reticulum and releasing one or more active substances into the environment of said rumen or reticulum at a substantially constant rate over a prolonged period of time, which comprises said active agent or substances homogeneously dispersed in a matrix and contained by means of an all-covering essentially impermeable wall or coating except for one or more strips of removed wall or coating from the side of said bolus.
Claim 13
Dependent Claim
90 words
A bolus for oral administration into the reticulum or rumen of a ruminant mammal, said bolus being retained in said rumen or reticulum and releasing one or more active substances into the environment of said rumen or reticulum at a substantially constant rate over a prolonged period of time, which comprises said active agent or substances homogeneously dispersed in a matrix and contained by means of an all-covering essentially impermeable wall or coating except for one or more strips of removed wall or coating from the side of said bolus.
Claim 14
Dependent Claim
21 words
A bolus of claim 11, wherein the active substance is morantel or a pharmaceutically acceptable salt thereof in a polymer matrix.
Claim 15
Dependent Claim
76 words
A tablet for oral administration to a mammal which releases a pharmaceutically active substance into the fluid of the gastrointestinal tract of said mammal at a substantially constant rate over an appreciable time interval which comprises said substance homogeneously dispersed, with or without one or more pharmaceutically-acceptable excipients and contained by means of an all-covering impermeable wall or coating except for one or more strips of removed wall or coating from the side of said tablet.
Claim 16
Dependent Claim
76 words
A tablet for oral administration to a mammal which releases a pharmaceutically active substance into the fluid of the gastrointestinal tract of said mammal at a substantially constant rate over an appreciable time interval which comprises said substance homogeneously dispersed, with or without one or more pharmaceutically-acceptable excipients and contained by means of an all-covering impermeable wall or coating except for one or more strips of removed wall or coating from the side of said tablet.
Claim 17
Dependent Claim
11 words
A tablet of claim 13, wherein the substance is an antihypertensive.
Claim 18
Dependent Claim
10 words
A tablet of claim 14, wherein the substance is prazosin.
Claim 19
Dependent Claim
10 words
A tablet of claim 14, wherein the substance is nifedipine.
Claim 20
Dependent Claim
10 words
A tablet of claim 14, wherein the substance is trimazosin.
Claim 21
Dependent Claim
10 words
A tablet of claim 14, wherein the substance is doxazosin.
Claim 22
Dependent Claim
12 words
A tablet of claim 13, wherein the substance is an antianxiety agent.
Claim 23
Dependent Claim
10 words
A tablet of claim 19, wherein the substance is hydroxyzine.
Claim 24
Dependent Claim
10 words
A tablet of claim 19, wherein the substance is sertraline.
Claim 25
Dependent Claim
11 words
A tablet of claim 13, wherein the substance is a bronchodilator.
Claim 26
Dependent Claim
10 words
A tablet of claim 22, wherein the substance is pirbuterol.
Claim 27
Dependent Claim
13 words
A tablet of claim 13, wherein the substance is a blood-glucose lowering agent.
Claim 28
Dependent Claim
10 words
A tablet of claim 24, wherein the substance is glipizide.
Claim 29
Dependent Claim
14 words
A tablet of claim 13, wherein the substance is a cough or cold agent.
Claim 30
Dependent Claim
11 words
A tablet of claim 26, wherein the substance is brompheniramine maleate.
Claim 31
Dependent Claim
11 words
A tablet of claim 26, wherein the substance is chlorpheniramine maleate.
Claim 32
Dependent Claim
11 words
A tablet of claim 26, wherein the substance is phenylephrine hydrochloride.
Claim 33
Dependent Claim
11 words
A tablet of claim 26, wherein the substance is pseudoephedrine hydrochloride.
Claim 34
Dependent Claim
10 words
A tablet of claim 26, wherein the substance is cetirizine.
Claim 35
Dependent Claim
11 words
A tablet of claim 26, wherein the substance is dexbrompheniramine maleate.
References Cited (Backward Citations)
US3851648A
Cited
US4690824A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-12-20 | 1992-06-20 | 1992-12-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-12-20 | 1996-06-20 | 1996-12-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-12-20 | 2000-06-20 | 2000-12-20 | $7700.00 | Window Closed / Lapsed |