US4789724A
Expired / Lapsed
US
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Preparation of anhydride copolymers
Assignee: Massachusetts Institute of Technology
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Filing: 1986-10-17
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Granted: 1988-12-06
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Expires: 2006-10-17
Abstract
Abstract A method for preparation of very pure anhydride copolymers with high yield. The anhydride copolymers, consisting of aromatic and aliphatic diacids are formed by melt condensation of individually prepared, pure, isolated prepolymers. The method of preparation is characterized by high yield, reproducibility, polymer purity and controlled composition, and is a short and convenient procedure. The polyanhydrides produced by the disclosed method are particularly well suited to biomedical applications requiring low levels of toxic or inflammatory contaminants and physical and mechanical properties which closely conform to manufacturing specifications.
Inventors
- 👤 Abraham J. Domb
- 👤 Robert S. Langer
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 05:48
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/20; A61K9/2004; A61K9/2022; A61K9/2031; C; C08; C08G; C08G67/00; C08G67/04
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
79 words
A method for preparing highly pure anhydride copolymers comprising: providing at least two individually synthetized and purified diacids, reacting the individual diacids and acetic anhydride separately to form mixed anhydrides of the invididual diacids, separately removing the unreacted acetic anhydride and diacids from the individual mixed anhydrides formed by the reaction of the acetic anhydride with said diacids, combining said individual mixed anhydrides, and polymerizing said mixture of the purified mixed anhydrides of the individual diacids to form copolymers.
Claim 2
Independent Claim
79 words
A method for preparing highly pure anhydride copolymers comprising: providing at least two individually synthetized and purified diacids, reacting the individual diacids and acetic anhydride separately to form mixed anhydrides of the invididual diacids, separately removing the unreacted acetic anhydride and diacids from the individual mixed anhydrides formed by the reaction of the acetic anhydride with said diacids, combining said individual mixed anhydrides, and polymerizing said mixture of the purified mixed anhydrides of the individual diacids to form copolymers.
Claim 3
Dependent Claim
30 words
The method of claim 1 wherein the diacids are selected form the group consisting of sebacic acid, bis(p-carboxyphenoxy-propane, bis(p-carboxyphenoxy)hexane, isophthalic acid, 1,4 phenylene diporpionic acid, adipic acid and dodecanedioic acid.
Claim 4
Dependent Claim
46 words
A highly pure anhydride copolymer consisting essentially of individually synthetisized and purified monomers selected from the group consisting of mixed anhydrides of aliphatic and aromatic diacids, wherein said diacids were individually reacted with acetic anhydride and the unreacted diacid and acetic anhydride removed after the reaction.
Claim 5
Dependent Claim
46 words
A highly pure anhydride copolymer consisting essentially of individually synthetisized and purified monomers selected from the group consisting of mixed anhydrides of aliphatic and aromatic diacids, wherein said diacids were individually reacted with acetic anhydride and the unreacted diacid and acetic anhydride removed after the reaction.
Claim 6
Dependent Claim
36 words
The anhydride copolymer of claim 3 wherein said mixed anhydrides are formed by separately refluxing individual diacids with acetic anhydride to form individual mixed anhydrides, removing the excess acetic anhydride, and recrystallizing the individual mixed anhydrides.
Claim 7
Dependent Claim
14 words
The anhydride copolymer of claim 3 wherein the copolymers are further purified by recrystallization.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-12-06 | 1992-06-06 | 1992-12-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-12-06 | 1996-06-06 | 1996-12-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-12-06 | 2000-06-06 | 2000-12-06 | $7700.00 | Window Closed / Lapsed |