US4788290A
Expired / Lapsed
US
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Serotonergic pyrazine derivatives
Assignee: Wyeth LLC
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Filing: 1987-12-11
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Granted: 1988-11-29
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Expires: 2007-12-11
Abstract
Abstract The compounds <IMAGE> in which X and Y are, independently, -O- or -S-; R1 and R2 are, independently, halo, trifluoromethyl, cyano, hydroxy, amino, alkylamino, dialkylamino, alkoxy, alkyl or alkanoylamino; and n is 1 to 4; or a pharmaceutically acceptable salt thereof, are selective serotonergic agents useful in the treatment of depression and/or anxiety, as well as related sexual dysfunctions and appetite disorders.
Inventors
- 👤 Gary P. Stack
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 17:55
CPC Classifications
C; C07; C07D; C07D405/00; C07D405/02; C07D405/12; C07D409/00; C07D409/02; C07D409/12; C07D411/00; C07D411/02; C07D411/12
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
83 words
A compound of the formula: ##STR7## in which X and Y are, independently, --O-- or --S--; R 1 and R 2 are, independently, hydrogen, halo, trifluoromethyl, cyano, hydroxy, amino, alkylamino of 1 to 6 carbon atoms, dialkylamino of 2 to 12 carbon atoms, alkoxy of 1 to 6 carbon atoms, alkyl of 1 to 6 carbon atoms or alkanoylamido of 2 to 6 carbon atoms; and n is one of the integers 1, 2, 3 or 4; or a pharmaceutically acceptable salt thereof.
Claim 2
Dependent Claim
83 words
A compound of the formula: ##STR7## in which X and Y are, independently, --O-- or --S--; R 1 and R 2 are, independently, hydrogen, halo, trifluoromethyl, cyano, hydroxy, amino, alkylamino of 1 to 6 carbon atoms, dialkylamino of 2 to 12 carbon atoms, alkoxy of 1 to 6 carbon atoms, alkyl of 1 to 6 carbon atoms or alkanoylamido of 2 to 6 carbon atoms; and n is one of the integers 1, 2, 3 or 4; or a pharmaceutically acceptable salt thereof.
Claim 3
Dependent Claim
78 words
A compound of claim 1 of the formula: ##STR8## in which R 1 and R 2 are, independently, hydrogen, halo, trifluoromethyl, cyano, hydroxy, amino, alkylamino of 1 to 6 carbon atoms, dialkylamino of 2 to 12 carbon atoms, alkoxy of 1 to 6 carbon atoms, alkyl of 1 to 6 carbon atoms or alkanoylamido of 2 to 6 carbon atoms; and n is one of the integers 1, 2, 3 or 4; or a pharmaceutically acceptable salt thereof.
Claim 4
Dependent Claim
14 words
The compound of claim 1 which is 2-(4-(2,3-dihydro-1,4-benzodioxin-2-ylmethyl)-1-piperazinyl]pyrazine or a pharmaceutically acceptable salt thereof.
Claim 5
Dependent Claim
14 words
The compound of claim 1 which is 2-chloro-6-[4-(2,3-dihydro-1,4-benzodioxin-2-ylmethyl)-1-piperazinyl]pyrazine or a pharmaceutically acceptable salt thereof.
Claim 6
Dependent Claim
14 words
The compound of claim 1 which is 2-chloro-3-[4-(2,3-dihydro-1,4-benzodioxin-2-ylmethyl)-1-piperazinyl]pyrazine or a pharmaceutically acceptable salt thereof.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-11-29 | 1992-05-30 | 1992-11-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-11-29 | 1996-05-30 | 1996-11-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-11-29 | 2000-05-30 | 2000-11-29 | $7700.00 | Window Closed / Lapsed |