Dihydropyridine anti-allergic and antiinflammatory agents

Claim 1

A compound of the formula ##STR61## or a pharmaceutically acceptable salt thereof, wherein R is phenyl, fluorophenyl, chlorophenyl, trifluoromethylphenyl, difluorophenyl, methylphenyl or methoxyphenyl; R 1 is hydrogen, alkyl having one to six carbon atoms, cycloalkyl having from three to seven carbon atoms, cycloalkylmethyl having four to eight carbon atoms, phenyl, phenylalkyl having seven to nine carbon atoms, indanyl, thenyl, pyridyl, methylpyridyl, picolyl, chloropyridyl, 2-thiazolyl, methyl-2-thiazolyl, dimethyl-2-thiazolyl, 2-benzothiazolyl, 6-alkoxy-2-benzothiazolyl said alkoxy having one to three carbon atoms, 1,3,4-thiadiazol-2-yl, 5-methyl-1,3,4-thiadiazol-2-yl, quinolyl, 3-isoxazolyl, 5-methyl-3-isoxazolyl, methylpyrazol-1-ylmethyl, or alpha-carboalkoxybenzyl said alkoxy having from one to three carbon atoms; R 2 is hydrogen or alkyl having one to six carbon atoms; R 1 and R 2 taken together with the nitrogen to which they are attached form a heterocyclic ring selected from piperidine, morpholine, thiomorpholine, piperazine or N-substituted piperazine where said substituent is alkyl having one to five carbon atoms, phenyl or alkanoyl having one to four carbon atoms; R 3 is alkyl having one to six carbon atoms or ethoxyalkyl having four to six carbon atoms; Y is alkylene having two to eight carbon atoms, having at least two carbon atoms in the chain linking X to the oxygen atom; and X is imidazol-1-yl optionally substituted with from one to three substituents selected from methyl and chloro.