US4787976A
Expired / Lapsed
US
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Non-adsorptive, semipermeable filtration membrane
Assignee: ARBIOS TECHONOLOGIES Inc
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Filing: 1985-04-29
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Granted: 1988-11-29
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Expires: 2005-04-29
Abstract
Abstract Disclosed is a protein non-adsorptive semipermeable filtration membrane and a process for producing the same. Said membrane, which comprises an interpenetrating polymer network, is prepared from a casting solution comprising a prepolymer polymerizable upon contact with a coagulating liquid, a polymer that will not react readily with the prepolymer and that is substantially insoluble in said coagulating liquid, and solvent.
Inventors
- 👤 Marc E. Parham
- 👤 Karen E. Milligan
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 21:44
CPC Classifications
B; B01; B01D; B01D67/00; B01D67/0002; B01D67/0006; B01D67/0009; B01D67/0016; B01D67/00165; B01D69/00; B01D69/02; B01D69/08; B01D71/00; B01D71/06; B01D71/54; C; C08; C08L; C08L75/00; C08L75/04; C08L75/08; D; D01; D01D; D01D5/00; D01D5/24; B01D2323/00; B01D2323/12; B01D2323/15; B01D2323/18; B01D2325/00; B01D2325/36
Claims Analysis
Total Claims: 47
Claim 1
Independent Claim
70 words
A self-supported substantially protein non-adsorptive, semipermeable filtration membrane consisting essentially of an interpenetrating polymer network prepared from a casting solution comprising (i) an isocyanate capped urethane prepolymer polymerizable upon contact with a coagulating liquid, (ii) a polymer that will not react readily with the prepolymer and that is substantially insoluble in said coagulating liquid, said polymer selected from the group acrylonitrile-vinyl chloride copolymer, polysulfone and cellulose acetate, and (iii) solvent.
Claim 2
Dependent Claim
70 words
A self-supported substantially protein non-adsorptive, semipermeable filtration membrane consisting essentially of an interpenetrating polymer network prepared from a casting solution comprising (i) an isocyanate capped urethane prepolymer polymerizable upon contact with a coagulating liquid, (ii) a polymer that will not react readily with the prepolymer and that is substantially insoluble in said coagulating liquid, said polymer selected from the group acrylonitrile-vinyl chloride copolymer, polysulfone and cellulose acetate, and (iii) solvent.
Claim 3
Dependent Claim
14 words
The membrane of claim 1 wherein the prepolymer is a substantially protein non-adsorptive prepolymer.
Claim 4
Dependent Claim
21 words
The membrane of claim 1 wherein the urethane prepolymer is polymerizable upon contact with water and the polymer is substantially water-insoluble.
Claim 5
Dependent Claim
14 words
The membrane of claim 3 wherein the membrane is an anisotropic, hollow fiber membrane.
Claim 6
Dependent Claim
12 words
The membrane of claim 4 wherein the membrane is an ultrafiltration membrane.
Claim 7
Dependent Claim
24 words
The membrane of claim 4 wherein the casting solution comprises from 5-25% by weight urethane prepolymer and from 5-25% by weight substantially water-insoluble polymer.
Claim 8
Dependent Claim
17 words
The membrane of claim 6 wherein the casting solution further comprises 0-10% by weight pore forming agent.
Claim 9
Dependent Claim
31 words
The membrane of claim 7 wherein the casting solution comprises from 8-12% by weight urethane prepolymer, from 10-15% by weight substantially water-insoluble polymer, and from 4-6% by weight pore forming agent.
Claim 10
Dependent Claim
14 words
The membrane of claim 3 wherein the membrane is an anisotropic flat sheet membrane.
Claim 11
Dependent Claim
24 words
The membrane of claim 9 wherein the casting solution comprises from 3-6% by weight urethane prepolymer and from 0-15% by weight substantially water-insoluble polymer.
Claim 12
Dependent Claim
14 words
The membrane of claim 3 wherein the substantially water-insoluble polymer comprises acrylonitrile-vinyl chloride copolymer.
Claim 13
Dependent Claim
12 words
The membrane of claim 3 wherein the substantially water-insoluble polymer comprises polysulfone.
Claim 14
Dependent Claim
12 words
The membrane of claim 1 wherein the membrane is an ultrafiltration membrane.
Claim 15
Dependent Claim
12 words
The membrane of claim 1 wherein the membrane is a microfiltration membrane.
Claim 16
Dependent Claim
16 words
The membrane of claim 1 wherein the urethane prepolymer comprises an isocyanate capped polyether urethane prepolymer.
Claim 17
Dependent Claim
18 words
The membrane of claim 15 wherein the urethane prepolymer comprises a hydrophilic, isocyanate capped polyethylene glycol urethane prepolymer.
Claim 18
Dependent Claim
17 words
The membrane of claim 16 wherein the urethane prepolymer has an average isocyanate functionality greater than two.
Claim 19
Dependent Claim
29 words
The membrane of claim 1 wherein the solvent is an organic solvent selected from the group consisting of N-Methylpyrrolidinone, N,N dimethylacetamide, acetone, methanol, dimethyl formamide, and 4-hydroxybutyric acid γ-lactone.
Claim 20
Dependent Claim
15 words
The membrane of claim 1 wherein the casting solution further comprises a pore forming agent.
Claim 21
Dependent Claim
12 words
The membrane of claim 19 wherein the pre forming agent comprises formamide.
Claim 22
Dependent Claim
18 words
The membrane of claim 1 wherein the interpenetrating polymer network comprises acrylonitrile-vinyl chloride and polyethylene glycol urethane urea.
Claim 23
Dependent Claim
17 words
The membrane of claim 1, wherein the interpenetrating polymer network comprises polysulfone and polyethylene glycol urethane urea.
Claim 24
Dependent Claim
61 words
A substantially protein non-adsorptive, anisotropic, semipermeable, hollow fiber ultrafiltration membrane consisting essentially of an interpenetrating polymer network prepared from a casting solution comprising (i) a hydrophilic isocyanate capped polyethylene glycol urethane prepolymer, (ii) a substantially water-insoluble polymer that will not react readily with the prepolymer, said polymer selected from the group acrylonitrile-vinyl chloride copolymer, polysulfone and cellulose acetate, and (iii) solvent.
Claim 25
Dependent Claim
61 words
A substantially protein non-adsorptive, anisotropic, semipermeable, hollow fiber ultrafiltration membrane consisting essentially of an interpenetrating polymer network prepared from a casting solution comprising (i) a hydrophilic isocyanate capped polyethylene glycol urethane prepolymer, (ii) a substantially water-insoluble polymer that will not react readily with the prepolymer, said polymer selected from the group acrylonitrile-vinyl chloride copolymer, polysulfone and cellulose acetate, and (iii) solvent.
Claim 26
Independent Claim
111 words
A method for producing a self-supported substantially protein non-adsorptive, semipermeable, anisotropic, filtration membrane consisting essentially of an interpenetrating polymer network which comprises the following steps: (a) casting a solution comprising a substantially protein non-adsorptive isocyanate capped urethane prepolymer, a polymer that will not react readily with the prepolymer, said polymer selected from the group acrylonitrile-vinyl chloride copolymer, polysulfone and cellulose acetate, and solvent on a support; (b) immersing the supported film in a coagulation bath comprising a coagulating liquid with which the protein non-adsorptive prepolymer is polymerizable upon contact and which is a non-solvent for the polymer and prepolymer; and (c) recovering the membrane produced in step b from the support.
Claim 27
Independent Claim
111 words
A method for producing a self-supported substantially protein non-adsorptive, semipermeable, anisotropic, filtration membrane consisting essentially of an interpenetrating polymer network which comprises the following steps: (a) casting a solution comprising a substantially protein non-adsorptive isocyanate capped urethane prepolymer, a polymer that will not react readily with the prepolymer, said polymer selected from the group acrylonitrile-vinyl chloride copolymer, polysulfone and cellulose acetate, and solvent on a support; (b) immersing the supported film in a coagulation bath comprising a coagulating liquid with which the protein non-adsorptive prepolymer is polymerizable upon contact and which is a non-solvent for the polymer and prepolymer; and (c) recovering the membrane produced in step b from the support.
Claim 28
Dependent Claim
31 words
The method of claim 24 wherein before the supported film is immersed in a coagulation bath in step b, the polymer layer formed on the support in step a is gelled.
Claim 29
Dependent Claim
13 words
The method of claim 24 wherein the coagulating liquid is an aqueous liquid.
Claim 30
Dependent Claim
38 words
The method of claim 24 wherein in step b, the film is immersed in the coagulation bath for between 5 seconds and 60 minutes and the coagulating liquid has a temperature between about 0° C. and 100° C.
Claim 31
Dependent Claim
20 words
The method of claim 24 wherein the isocyanate capped urethane prepolymer comprises a hydrophilic isocyanate capped polyethylene glycol urethane prepolymer.
Claim 32
Dependent Claim
18 words
The method of claim 24 wherein in step a, the casting solution further comprises a pore forming agent.
Claim 33
Independent Claim
119 words
A method for producing a substantially protein non-adsorptive, semipermeable, anisotropic, hollow fiber filtration membrane consisting essentially of an interpenetration polymer network which comprises the following steps: (a) preparing a casting solution comprising a substantially protein non-adsorptive isocyaate capped urethane prepolymer, a polymer that will not react readily with the prepolymer, said polymer selected from the group acrylonitrile-vinyl chloride copolymer polysulfone and cellulose acetate, and solvent; (b) spinning said casting solution through a spinneret for hollow fiber production while simultaneously introducing through the central aperture of said spinneret a coagulating liquid with which the protein non-adsorption prepolymer is polymerizable upon contact and which is a non-solvent for the polymer and prepolymer; and (c) recovering the membrane produced in step b.
Claim 34
Independent Claim
119 words
A method for producing a substantially protein non-adsorptive, semipermeable, anisotropic, hollow fiber filtration membrane consisting essentially of an interpenetration polymer network which comprises the following steps: (a) preparing a casting solution comprising a substantially protein non-adsorptive isocyaate capped urethane prepolymer, a polymer that will not react readily with the prepolymer, said polymer selected from the group acrylonitrile-vinyl chloride copolymer polysulfone and cellulose acetate, and solvent; (b) spinning said casting solution through a spinneret for hollow fiber production while simultaneously introducing through the central aperture of said spinneret a coagulating liquid with which the protein non-adsorption prepolymer is polymerizable upon contact and which is a non-solvent for the polymer and prepolymer; and (c) recovering the membrane produced in step b.
Claim 35
Dependent Claim
18 words
The method of claim 30 wherein in step a, the casting solution further comprises a pore forming agent.
Claim 36
Dependent Claim
20 words
The method of claim 30 wherein the isocyanate capped urethane prepolymer comprises a hydrophilic, isocyanate capped polyethylene glycol urethane prepolymer.
Claim 37
Dependent Claim
22 words
The method of claim 30 wherein in step b, the casting solution is spun through the spinneret at a constant steady pressure.
Claim 38
Dependent Claim
17 words
The method of claim 33 wherein the constant steady pressure ranges from about 1 to 60 psi.
Claim 39
Dependent Claim
20 words
The method of claim 30 wherein in the step b, the coagulating liquid introduced through the central aperature is aqueous.
Claim 40
Dependent Claim
19 words
The method of claim 35 wherein the coagulating liquid has a temperature between about 0° C. and 100° C.
Claim 41
Independent Claim
118 words
A method for producing a self-supported substantially protein non-adsorptive, semipermeable, anisotropic, filtration membrane consisting essentially of an interpenetrating polymer network, which comprises the following steps: (a) casting a solution comprising a substantially protein non-adsorptive isocyanate capped urethane prepolymer, a polymer that will not react readily with the prepolymer, said polymer selected from the group acrylonitrile-vinyl chloride copolymer, polysulfone and cellulose acetate, and solvent on a support; (b) immersing the supported film in a coagulation bath comprising a coagulating liquid with which the protein non-adsorptive prepolymer is polymerizable upon contact, which is a non-solvent for the polymer and prepolymer, and which comprises up to about 25% polyamine; and (c) recovering the membrane produced in step b from the support.
Claim 42
Independent Claim
118 words
A method for producing a self-supported substantially protein non-adsorptive, semipermeable, anisotropic, filtration membrane consisting essentially of an interpenetrating polymer network, which comprises the following steps: (a) casting a solution comprising a substantially protein non-adsorptive isocyanate capped urethane prepolymer, a polymer that will not react readily with the prepolymer, said polymer selected from the group acrylonitrile-vinyl chloride copolymer, polysulfone and cellulose acetate, and solvent on a support; (b) immersing the supported film in a coagulation bath comprising a coagulating liquid with which the protein non-adsorptive prepolymer is polymerizable upon contact, which is a non-solvent for the polymer and prepolymer, and which comprises up to about 25% polyamine; and (c) recovering the membrane produced in step b from the support.
Claim 43
Dependent Claim
18 words
The method of claim 37 wherein the interpenetrating polymer network comprises acrylonitrile-vinyl chloride and polyethylene glycol urethane urea.
Claim 44
Dependent Claim
17 words
The method of claim 37 wherein the interpenetrating polymer network comprises polysulfone and polyethylene glycol urethane urea.
Claim 45
Dependent Claim
15 words
The method of claim 37 wherein the coagulating liquid has a pH of between 7-12.
Claim 46
Independent Claim
126 words
A method for producing a substantially protein non-adsorptive, semipermeable, anisotropic, hollow fiber filtration membrane consisting essentially of an interpenetrating polymer network, which comprises the following steps: (a) preparing a casting solution comprising a substantially protein non-adsorptive isocyanate capped urethane prepolymer, a polymer that will not react readily with the prepolymer, said polymer selected from the group acrylonitrile-vinyl chloride copolymer, polysulfone and cellulose acetate, and solvent; (b) spinning said casting solution through a spinneret for hollow fiber production while simultaneously introducing through the central aperture of said spinneret a coagulating liquid with which the protein non-adsorptive prepolymer is polymerizable upon contact, which is a non-solvent for the polymer and prepolymer, and which comprises up to about 25% polyamine; and (c) recovering the membrane produced in step b.
Claim 47
Independent Claim
126 words
A method for producing a substantially protein non-adsorptive, semipermeable, anisotropic, hollow fiber filtration membrane consisting essentially of an interpenetrating polymer network, which comprises the following steps: (a) preparing a casting solution comprising a substantially protein non-adsorptive isocyanate capped urethane prepolymer, a polymer that will not react readily with the prepolymer, said polymer selected from the group acrylonitrile-vinyl chloride copolymer, polysulfone and cellulose acetate, and solvent; (b) spinning said casting solution through a spinneret for hollow fiber production while simultaneously introducing through the central aperture of said spinneret a coagulating liquid with which the protein non-adsorptive prepolymer is polymerizable upon contact, which is a non-solvent for the polymer and prepolymer, and which comprises up to about 25% polyamine; and (c) recovering the membrane produced in step b.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-11-29 | 1992-05-30 | 1992-11-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-11-29 | 1996-05-30 | 1996-11-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-11-29 | 2000-05-30 | 2000-11-29 | $7700.00 | Window Closed / Lapsed |