US4785012A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Oxazole anthelmintic agents of marine origin
Assignee: University of California
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Filing: 1987-04-09
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Granted: 1988-11-15
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Expires: 2007-04-09
Abstract
Abstract New oxazole derivatives of formula 1 and their pharmacetically acceptable salts have anthelmintic activity: <IMAGE> (1) where R is H, OH, or acyloxy of 8 to 22 carbon atoms; R1, R2, R3, and R4 are each independently H or acyl of 1 to 6 carbon atoms.
Inventors
- 👤 Philip Crews
- 👤 Thomas R. Matthews
- 👤 Emilio Q. Cabana
- 👤 Madeline Adamczeski
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 13:52
CPC Classifications
C; C07; C07D; C07D263/00; C07D263/02; C07D263/30; C07D263/32
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
54 words
A compund in substantially pure form of formula 1: ##STR7## where R is H, OH, or saturated acyloxy of 8 to 22 carbon atoms; R 1 , R 2 , R 3 , and R 4 are each independently H or acyl of 1 to 6 carbon atoms; and the pharmaceutically acceptable salts thereof.
Claim 2
Dependent Claim
54 words
A compund in substantially pure form of formula 1: ##STR7## where R is H, OH, or saturated acyloxy of 8 to 22 carbon atoms; R 1 , R 2 , R 3 , and R 4 are each independently H or acyl of 1 to 6 carbon atoms; and the pharmaceutically acceptable salts thereof.
Claim 3
Dependent Claim
21 words
The compound of claim 1 wherein R 1 , R 2 , R 3 , and R 4 are each H.
Claim 4
Dependent Claim
9 words
The compound of claim 2 wherein R is H.
Claim 5
Dependent Claim
16 words
The compound of claim 2 wherein R is saturated acyloxy of 8 to 22 carbon atoms.
Claim 6
Dependent Claim
10 words
The compound of claim 4 wherein R is saturated tetradecanoyl.
Claim 7
Dependent Claim
9 words
The compound of claim 4 wherein R is 13-methyltetradecanoyl.
Claim 8
Dependent Claim
21 words
The compound of claim 1 wherein R 1 , R 2 , R 3 , and R 4 are each acetyl.
Claim 9
Dependent Claim
9 words
The compound of claim 7 wherein R is tetradecanoyl.
Claim 10
Dependent Claim
9 words
The compound of claim 7 wherein R is 13-methyltetradecanoyl.
Claim 11
Independent Claim
101 words
A method for treating helminthiasis which method comprises administering to a subject in need thereof an effective amount of a compound in substantially pure form of formula 1: ##STR8## wherein R is H, OH, or saturated acyloxy of 8 to 22 carbon atoms; R 1 , R 2 , R 3 , and R 4 are each independently H or acyl of 1 to 6 carbon atoms; and the pharmaceuticlaly acceptable salts thereof or an effective amount of a phramaceutical composition wherein the active ingredient is a substantially pure form of the compound of formula 1 or its pharmaceutically acceptable salts.
Claim 12
Independent Claim
101 words
A method for treating helminthiasis which method comprises administering to a subject in need thereof an effective amount of a compound in substantially pure form of formula 1: ##STR8## wherein R is H, OH, or saturated acyloxy of 8 to 22 carbon atoms; R 1 , R 2 , R 3 , and R 4 are each independently H or acyl of 1 to 6 carbon atoms; and the pharmaceuticlaly acceptable salts thereof or an effective amount of a phramaceutical composition wherein the active ingredient is a substantially pure form of the compound of formula 1 or its pharmaceutically acceptable salts.
Claim 13
Dependent Claim
27 words
The method of claim 10 wherein R 1 , R 2 , R 3 , and R 4 are each H; and R is tetradecanoyl or 13-methyltetradecanoyl.
Claim 14
Dependent Claim
70 words
A composition for treating helminthiasis, which comprises a pharmaceutically acceptable excipient and an effective amount of a compound in substantially pure form of formula 1: ##STR9## where R is H, OH, or saturated acyloxy of 8 to 22 carbon atoms; R 1 , R 2 , R 3 , and R 4 are each independently H or acyl of 1 to 6 carbon atoms; and the pharmaceutically acceptable salts thereof.
Claim 15
Dependent Claim
70 words
A composition for treating helminthiasis, which comprises a pharmaceutically acceptable excipient and an effective amount of a compound in substantially pure form of formula 1: ##STR9## where R is H, OH, or saturated acyloxy of 8 to 22 carbon atoms; R 1 , R 2 , R 3 , and R 4 are each independently H or acyl of 1 to 6 carbon atoms; and the pharmaceutically acceptable salts thereof.
Claim 16
Dependent Claim
21 words
The composition of claim 12 wherein R 1 , R 2 , R 3 , and R 4 are each H.
Claim 17
Dependent Claim
9 words
The composition of claim 13 wherein R is H.
Claim 18
Dependent Claim
15 words
The composition of claim 13 wherein R is acyloxy of 8 to 22 carbon atoms.
Claim 19
Dependent Claim
9 words
The composition of claim 15 wherein R is tetradecanoyl.
Claim 20
Dependent Claim
9 words
The composition of claim 15 wherein R is 13-methyltetradecanoyl.
Claim 21
Dependent Claim
21 words
The composition of claim 12 wherein R 1 , R 2 , R 3 , and R 4 are each acetyl.
Claim 22
Dependent Claim
9 words
The composition of claim 18 wherein R is tetradecanoyl.
Claim 23
Dependent Claim
9 words
The composition of claim 18 wherein R is 13-methyltetradecanoyl.
References Cited (Backward Citations)
US3438943A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-11-15 | 1992-05-16 | 1992-11-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-11-15 | 1996-05-16 | 1996-11-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-11-15 | 2000-05-16 | 2000-11-15 | $7700.00 | Window Closed / Lapsed |