US4783529A
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Rapid synthesis of radiolabeled porphyrin complexes for medical application
Assignee: RESEARCH Corp A NEW YORK NOT-FOR-PROFIT CORPORATION
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Filing: 1985-12-03
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Granted: 1988-11-08
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Expires: 2005-12-03
Abstract
Abstract This invention relates to a novel method for the rapid synthesis of radiolabeled porphyrin complexes which are highly useful for biomedical application, i.e. conjugation to protein antibodies for use in tumor imaging and internal radiation therapy.
Inventors
- 👤 David K. Lavallee
- 👤 Daniel Mansuy
- 👤 Jean-Paul Battioni
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 18:51
CPC Classifications
C; C07; C07D; C07D487/00; C07D487/22
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
48 words
A process for the preparation of N-substituted porphyrins of the formula: ##STR6## wherein X is hydrogen, hydroxy, nitro, lower alkyl or lower alkoxy and R is carboxy or sulfonato which comprises contacting a porphyrin compound with a benzyl diphenylsulfonium compound in the presence of an inert organic solvent.
Claim 2
Dependent Claim
48 words
A process for the preparation of N-substituted porphyrins of the formula: ##STR6## wherein X is hydrogen, hydroxy, nitro, lower alkyl or lower alkoxy and R is carboxy or sulfonato which comprises contacting a porphyrin compound with a benzyl diphenylsulfonium compound in the presence of an inert organic solvent.
Claim 3
Dependent Claim
16 words
The process according to claim 1 wherein the benzyl diphenylsulfonium compound is a benzyl diphenylsulfonium salt.
Claim 4
Dependent Claim
17 words
The process according to claim 2 wherein the salt is benzyldiphenylsulfonium tetrafluoroborate and the solvent is dichloromethane.
Claim 5
Dependent Claim
14 words
The process according to claim 1 wherein the porphyrin compound is 5,10,15,20-tetrakis(p-carboxyphenyl)porphyrin or 5-(p-carboxyphenyl)-10,15,20-tris(p-sulfophenyl)porphyrin.
Claim 6
Dependent Claim
26 words
The process according to claim 1 wherein the benzyl group of the benzyldiphenylsulfonium compound is unsubstituted or mono-substituted with hydroxy, nitro, lower alkyl or lower alkoxy.
Claim 7
Dependent Claim
13 words
The process according to claim 2 wherein the compound is a diphenyl-p-nitrobenzylsulfonium salt.
Claim 8
Dependent Claim
12 words
The process according to claim 2 wherein the salt is diphenyl-p-nitrobenzylsulfonium tetrafluoroborate.
Claim 9
Dependent Claim
27 words
A process for the preparation of N-benzylporphyrins which comprises contacting a naturally derived porphyrin with a benzyl diphenylsulfonium compound in the presence of an inert organic solvent.
Claim 10
Dependent Claim
27 words
A process for the preparation of N-benzylporphyrins which comprises contacting a naturally derived porphyrin with a benzyl diphenylsulfonium compound in the presence of an inert organic solvent.
Claim 11
Dependent Claim
15 words
The process according to claim 8 wherein the benzyl diphenylsulfonium compound is a benzyldiphenylsulfonium salt.
Claim 12
Dependent Claim
12 words
The process according to claim 9 wherein the salt is benzyldiphenylsulfonium tetrafluoroborate.
Claim 13
Dependent Claim
14 words
The process according to claim 8 wherein the porphyrin is hematoporphyrin, protoporphyrin or deuteroporphyrin.
Claim 14
Dependent Claim
1 words
N-benzylhematoporphyrin.
Claim 15
Dependent Claim
1 words
N-benzylhematoporphyrin.
Claim 16
Dependent Claim
1 words
N-benzylprotoporphyrin.
Claim 17
Dependent Claim
1 words
N-benzylprotoporphyrin.
Claim 18
Dependent Claim
1 words
N-benzyldeuteroporphyrin.
Claim 19
Dependent Claim
1 words
N-benzyldeuteroporphyrin.
Claim 20
Dependent Claim
1 words
N-benzyl5,10,15,20-tetrakis(p-carboxyphenyl)porphyrin.
Claim 21
Dependent Claim
1 words
N-benzyl5,10,15,20-tetrakis(p-carboxyphenyl)porphyrin.
Claim 22
Dependent Claim
1 words
N-p-nitrobenzyl-5-(p-carboxyphenyl)-10,15,20-tris(p-sulfophenyl)porphyrin.
Claim 23
Dependent Claim
1 words
N-p-nitrobenzyl-5-(p-carboxyphenyl)-10,15,20-tris(p-sulfophenyl)porphyrin.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-11-08 | 1992-05-09 | 1992-11-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-11-08 | 1996-05-09 | 1996-11-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-11-08 | 2000-05-09 | 2000-11-08 | $7700.00 | Window Closed / Lapsed |