US4783524A
Expired / Lapsed
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Growth factors
Assignee: Monsanto Technology LLC
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Filing: 1986-07-31
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Granted: 1988-11-08
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Expires: 2006-07-31
Abstract
Abstract This invention relates to novel peptides having utility for promotion of growth and/or lactation in animals, to processes and DNA useful in production of such peptides, and to methods utilizing such peptides to promote growth or lactation in animals. In some embodiments, the invention is directed to peptides having bovine IGF-II biological activity, to production of such peptides, and to their use in effecting proliferation of certain cells (e.g. mammary epithelial or muscle) or in enhancing lactation in cattle or other animals.
Inventors
- 👤 Brent R. Larsen
- 👤 Ned R. Siegel
- 👤 Claire E. Kotts
- 👤 Michael F. McGrath
- 👤 Sharon D. Ogden
- 👤 Gwen G. Krivi
- 👤 John C. Minnerly
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 01:37
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/575; C07K14/65; A; A23; A23K; A23K20/00; A23K20/10; A23K20/142; A23K20/147; A61; A61P; A61P5/00; A61K; A61K38/00; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/12
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
36 words
A peptide consisting essentially of the following sequence of amino acids, reading from the amino end to the carboxy end of said sequence: Ala-Tyr-Arg-Pro-Ser-Glu-Thr-Leu-Cys-Gly-Gly-Glu-Leu-Val-Asp-Thr-Leu-Gln-Phe-Val-Cys-Gly-Asp-Arg-Gly-Phe-Tyr-Phe-Ser-Arg-Pro-Ser-Ser-Arg-Ile-Asn-Arg-Arg-Ser-Arg-Gly-Ile-Val-Glu-Glu-Cys-Cys-Phe-Arg-Ser-Cys-Asp-Leu-Ala-Leu-Leu-Glu-Thr-Tyr-Cys-Ala-Thr-Pro-Ala Lys-Ser-Glu, said peptide being essentially free from other peptides of bovine origin.
Claim 2
Dependent Claim
36 words
A peptide consisting essentially of the following sequence of amino acids, reading from the amino end to the carboxy end of said sequence: Ala-Tyr-Arg-Pro-Ser-Glu-Thr-Leu-Cys-Gly-Gly-Glu-Leu-Val-Asp-Thr-Leu-Gln-Phe-Val-Cys-Gly-Asp-Arg-Gly-Phe-Tyr-Phe-Ser-Arg-Pro-Ser-Ser-Arg-Ile-Asn-Arg-Arg-Ser-Arg-Gly-Ile-Val-Glu-Glu-Cys-Cys-Phe-Arg-Ser-Cys-Asp-Leu-Ala-Leu-Leu-Glu-Thr-Tyr-Cys-Ala-Thr-Pro-Ala Lys-Ser-Glu, said peptide being essentially free from other peptides of bovine origin.
Claim 3
Dependent Claim
7 words
An essentially pure peptide of claim 1.
Claim 4
Dependent Claim
22 words
Peptide of claim 1 linked directly at its amino end to the carboxy terminus of the following sequence of amino acids: Met-Gly-Ile-Pro-Met-Gly-Lys-Ser-Met-Leu-Val-Leu-Leu-Thr-Phe-Leu-Ala-Phe-Ala-Ser-Cys-Cys-Ile-Ala-.
Claim 5
Dependent Claim
23 words
A peptide of claim 1 linked directly at its carboxy end to the amino-terminus of the following sequence of amino acids: -Arg-Asp-Val-Ser-Ala-Ser-Thr-Thr-Val-Leu-Pro-Asp-Asp-Val-Thr-Ala-Tyr-Pro-Val-Gly-Lys-Phe-Phe-Gln-Tyr-Asp-Ile-Trp-Lys-Gln-Ser-Thr-Gln-Arg-Leu-Arg-Arg-Gly-Leu-Pro-Ala-Phe-Leu-Arg-Ala-Arg-Arg-Gly-Arg-Thr-Leu-Ala-Lys-Glu-Leu-Glu-Ala-Leu-Arg-Glu-Ala-Lys-Ser-Hi -His-Pro-Leu-Ile.
Claim 6
Dependent Claim
43 words
A peptide of claim 1 linked directly at its carboxy end to the amino-terminus of the following first sequence of amino acids: Met-Gly-Ile-Pro-Met-Gly-Lys-Ser-Met-Leu-Val-Leu-Leu-Thr-Phe-Leu-Ala-Phe-Ala-Ser-Cys-Cys-Ile-Ala- and linked directly at its carboxy end to the amino-termius of the following second sequence of amino acids: -Arg-Asp-Val-Ser-Ala-Ser-Thr-Thr-Val-Leu-Pro-Asp-Asp-Val-Thr-Ala-Tyr-Pro-Val-Gly-Lys-Phe-Phe-Gln-Tyr-Asp-Ile-Trp-Lys-Gln-Ser-Thr-Gln-Arg-Leu-Arg-Arg-Gly-Leu-Pro-Ala-Phe-Leu-Arg-Ala-Arg-Arg-Gly-Arg-Thr-Leu-Ala-Lys-Glu-Leu-Glu-Ala-Leu-Arg-Glu-Ala-Lys-Ser-Hi -His-Pro-Leu-Ile.
Claim 7
Dependent Claim
49 words
A peptide of claim 1 that has an undenatured configuration resulting in bovine insulin-like growth factor II biological activity selected from the group consisting of mammary epithelial cell proliferation in a mammal, satellite muscle cell proliferation in an animal, and increased lactation by mammary epithelial cells in a mammal.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-11-08 | 1992-05-09 | 1992-11-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-11-08 | 1996-05-09 | 1996-11-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-11-08 | 2000-05-09 | 2000-11-08 | $7700.00 | Window Closed / Lapsed |