US4782149A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Pyridazodiazepine derivatives
Assignee: Hoffmann La Roche Inc
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Filing: 1988-03-17
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Granted: 1988-11-01
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Expires: 2008-03-17
Abstract
Abstract Compounds of the formula <IMAGE> I wherein R1 and R2 each independently represent hydrogen, C1-C10-alkyl, adamantyl-(C1-C4-alkyl) or (C2-C6-alkanoyloxy)-(C1-C4-alkyl), and pharmaceutically acceptable salts thereof possess antihypertensive activity and can be used as theraputic or prophylactic agents in pharmaceutical preparations. Intermediates for the production of such compounds are also provided.
Inventors
- 👤 Geoffrey Lawton
- 👤 Sally Redshaw
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 16:48
CPC Classifications
C; C07; C07D; C07D487/00; C07D487/02; C07D487/04; C07K; C07K5/00; C07K5/02; C07K5/022; C07K5/0222; A; A61; A61P; A61P9/00; A61P9/12; C07K5/04; C07K5/06; C07K5/06139
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
49 words
A compound of the formula ##STR11## wherein R 1 and R 2 each individually are hydrogen, C 1 -C 10 -alkyl, adamantyl-(C 1 -C 4 -alkyl) or (C 2 -C 6 -alkanoyloxy)-(C 1 -C 4 -alkyl), R 3 is hydrogen or benzyl, and S is nitro, amino or 2-nitroguanidino.
Claim 2
Dependent Claim
49 words
A compound of the formula ##STR11## wherein R 1 and R 2 each individually are hydrogen, C 1 -C 10 -alkyl, adamantyl-(C 1 -C 4 -alkyl) or (C 2 -C 6 -alkanoyloxy)-(C 1 -C 4 -alkyl), R 3 is hydrogen or benzyl, and S is nitro, amino or 2-nitroguanidino.
Claim 3
Dependent Claim
12 words
A compound according to claim 1, in which R 1 is hydrogen.
Claim 4
Dependent Claim
12 words
A compound according to claim 1, in which R 1 is ethyl.
Claim 5
Dependent Claim
12 words
A compound according to claim 1, in which R 1 is n-decyl.
Claim 6
Dependent Claim
12 words
A compound according to claim 1, in which R 1 is 1-adamantylethyl.
Claim 7
Dependent Claim
12 words
A compound according to claim 1, in which R 2 is hydrogen.
Claim 8
Dependent Claim
12 words
A compound according to claim 1, in which R 2 is pivaloyloxymethyl.
Claim 9
Dependent Claim
14 words
A compound according to claim 1, in which S is 2-nitroguanidino in the para-position.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-11-01 | 1992-05-02 | 1992-11-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-11-01 | 1996-05-02 | 1996-11-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-11-01 | 2000-05-02 | 2000-11-01 | $7700.00 | Window Closed / Lapsed |