US4780418A
Expired / Lapsed
US
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Method and apparatus for measuring the aggregation of blood platelets or the coagulation of blood
Assignee: Dade Behring Inc
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Filing: 1986-11-19
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Granted: 1988-10-25
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Expires: 2006-11-19
Abstract
Abstract A method and apparatus are disclosed for measuring the aggregation of blood platelets or the coagulation of blood, the apparatus including a capillary tube for drawing blood, a piston in communication with the capillary tube and connected to a motor means for linear displacement thereof, a pressure sensor in the space located between the drawn blood and piston, and a computing means or microprocessing means for comparing the sensed pressure from the pressure sensor with a predetermined value, and providing a measured regulating output to the motor means. The method for measuring the aggregation of blood platelets and coagulation of blood includes the steps of drawing blood into the capillary tube of the moveable piston until the desired pressure is achieved within the capillary tube, and allowing the computing means to then maintain by adjustment of the piston position the pressure within the capillary tube. The computing means is able to determine the amount of blood flowing into the capillary tube during constant pressure regulation, and hence the amount of aggregate of blood platelets and blood coagulation due to a known relationship relating movement of the piston to blood drawn into the cylinder.
Inventors
- 👤 Michael Kratzer
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 22:20
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/483; G01N33/487; G01N33/49; G01N33/4905
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
213 words
A method for measuring the extent of aggregation of blood-platelets in blood or the extent of coagulation of blood comprising the steps of: positioning a capillary tube, having first and second ends, adjacent a vessel containing a quantity of blood; positioning a syringe type arrangement comprising a cylinder and a piston adjacent said capillary tube, said first end of said capillary tube extending into said vessel and being in communication with the blood in the vessel and said second end of said capillary tube communicating with the cylinder of the syringe type arrangement; operating said piston to draw blood from the vessel into said capillary tube, thereby defining a pressure space between the piston and the blood in the capillary tube; moving the piston in a desired manner to thereby move the blood in the capillary tube in a desired manner; measuring the pressure in the pressure space; controlling the moving of said piston based on the pressure measurements to thereby control the pressure in said pressure space in a predetermined manner; and measuring the flow rate of the blood in the capillary tube as a measure of the extent of aggregation of blood-platelets in the blood in the capillary tube or the extent of coagulation of the blood in the capillary tube.
Claim 2
Independent Claim
213 words
A method for measuring the extent of aggregation of blood-platelets in blood or the extent of coagulation of blood comprising the steps of: positioning a capillary tube, having first and second ends, adjacent a vessel containing a quantity of blood; positioning a syringe type arrangement comprising a cylinder and a piston adjacent said capillary tube, said first end of said capillary tube extending into said vessel and being in communication with the blood in the vessel and said second end of said capillary tube communicating with the cylinder of the syringe type arrangement; operating said piston to draw blood from the vessel into said capillary tube, thereby defining a pressure space between the piston and the blood in the capillary tube; moving the piston in a desired manner to thereby move the blood in the capillary tube in a desired manner; measuring the pressure in the pressure space; controlling the moving of said piston based on the pressure measurements to thereby control the pressure in said pressure space in a predetermined manner; and measuring the flow rate of the blood in the capillary tube as a measure of the extent of aggregation of blood-platelets in the blood in the capillary tube or the extent of coagulation of the blood in the capillary tube.
Claim 3
Dependent Claim
44 words
The method according to claim 1 wherein the operating step draws a quantity of blood into the capillary tube and the moving step moves the piston so as to move the quantity of blood in the capillary tube in a back and forth motion.
Claim 4
Dependent Claim
28 words
The method according to claim 1 wherein the moving of said piston is controlled so as to maintain the pressure in said pressure space at a constant level.
Claim 5
Dependent Claim
45 words
The method according to claim 1 wherein the moving of said piston is controlled by a computer so that the pressure in said pressure space varies with time according to a predetermined function, with time-dependent pressure values for the function being stored in the computer.
Claim 6
Dependent Claim
20 words
The method according to claim 1 wherein the vessel comprises a catheter through which blood from a patient continuously flows.
Claim 7
Dependent Claim
35 words
The method according to claim 1 wherein specific substances which influence the aggregation of blood-platelets in blood or the coagulation of blood are added to the blood in the vessel prior to the operating step.
Claim 8
Independent Claim
190 words
An apparatus for measuring the extent of aggregation of blood-platelets in blood or the extent of coagulation of blood comprising: a capillary tube having first and second ends; a cylinder communicating with said first end of the capillary tube; a piston operatively disposed in the cylinder for drawing blood into the capillary tube through the second end thereof; a drive for moving said piston; a pressure sensor disposed between said second end of the capillary tube and the piston for generating pressure signals when blood is contained in the capillary tube to define a pressure space between such blood and the piston, with such pressure signals being indicative of the pressure within such a pressure space; and a computer operatively connected to said pressure sensor and said drive for receiving pressure signals from said pressure sensor, for operating the drive based on received pressure signals from the pressure sensor to control the movement of the piston to thereby control the pressure in a pressure space as defined above in a predetermined manner, and for determining the flow rate of blood in the capillary tube based on movements of the piston.
Claim 9
Independent Claim
190 words
An apparatus for measuring the extent of aggregation of blood-platelets in blood or the extent of coagulation of blood comprising: a capillary tube having first and second ends; a cylinder communicating with said first end of the capillary tube; a piston operatively disposed in the cylinder for drawing blood into the capillary tube through the second end thereof; a drive for moving said piston; a pressure sensor disposed between said second end of the capillary tube and the piston for generating pressure signals when blood is contained in the capillary tube to define a pressure space between such blood and the piston, with such pressure signals being indicative of the pressure within such a pressure space; and a computer operatively connected to said pressure sensor and said drive for receiving pressure signals from said pressure sensor, for operating the drive based on received pressure signals from the pressure sensor to control the movement of the piston to thereby control the pressure in a pressure space as defined above in a predetermined manner, and for determining the flow rate of blood in the capillary tube based on movements of the piston.
Claim 10
Dependent Claim
26 words
The apparatus according to claim 7 further including a piston-rod connected to the piston and wherein the drive comprises a stepping motor which actuates the piston-rod.
Claim 11
Dependent Claim
17 words
The apparatus according to claim 7 wherein the cylinder and the piston are parts of a syringe.
Claim 12
Dependent Claim
23 words
The apparatus according to claim 7 further including a blood reservoir connected between the first end of the capillary tube and the cylinder.
Claim 13
Dependent Claim
31 words
The apparatus according to claim 7 further including a catheter through which blood from a patient flows and wherein the capillary tube is connected to the catheter through a valve means.
Claim 14
Dependent Claim
12 words
The apparatus according to claim 7 wherein the capillary tube is replaceable.
Claim 15
Dependent Claim
24 words
The apparatus according to claim 7 wherein the computer also includes a table containing pressure values for calculating a signal for operating the drive.
References Cited (Backward Citations)
US3911728A
Cited
US4201222A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-10-25 | 1992-04-25 | 1992-10-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-10-25 | 1996-04-25 | 1996-10-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-10-25 | 2000-04-25 | 2000-10-25 | $7700.00 | Window Closed / Lapsed |