US4777953A
Expired / Lapsed
US
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Capillary filtration and collection method for long-term monitoring of blood constituents
Assignee: Ash Access Technology Inc
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Filing: 1987-02-25
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Granted: 1988-10-18
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Expires: 2007-02-25
Abstract
Abstract A method and device for long term monitoring of the blood level of various blood constituents. The monitoring is accomplished by capillary filtration and collection of an ultrafiltrate of blood. Filtration of the ultrafiltrate occurs through a filter composed of hollow fibers which are implanted within an interstitial body space in fluid communication with blood capillaries. The ultrafiltrate is drawn through the filter and into an ultrafiltrate collector which extends externally of the body. The collector provides a vacuum for withdrawing the ultrafiltrate and holds discrete liquid samples of the ultrafiltrate. The method and device is particularly suited for long term monitoring of blood glucose levels in diabetic patients or other blood chemical constituents in other patients.
Inventors
- 👤 Stephen R. Ash
- 👤 Elsa M. Janle-Swain
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 01:35
CPC Classifications
B; B01; B01D; B01D63/00; B01D63/02; B01D63/024; A; A61; A61B; A61B5/00; A61B5/145; A61B5/14525; A61B5/14528; A61B5/14542; A61B5/1468; A61B5/1486; A61B5/14865; A61B5/41; A61B5/414; A61B5/415; A61B5/68; A61B5/6846; A61B5/6847; A61B5/686; B01D61/00; B01D61/14; B01D61/18; A61B10/00; A61B10/0045; A61B2010/008; B01D2313/00; B01D2313/06
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
98 words
A method for continuous long term monitoring of the blood level of a physiological constituent of blood, comprising the steps of: implanting a porous membrane filter within an interstitial body space in fluid communication with blood capillaries; filtering an ultrafiltrate of blood from the capillaries by exerting a negative pressure withdrawal force on the porous membrane filter so as to cause the ultrafiltrate to flow from the capillaries through the filter at a desired flow rate; collecting the ultrafiltrate in a reservoir located externally of the body; and assaying the ultrafiltrate to measure a desired physiological constituent thereof.
Claim 2
Independent Claim
98 words
A method for continuous long term monitoring of the blood level of a physiological constituent of blood, comprising the steps of: implanting a porous membrane filter within an interstitial body space in fluid communication with blood capillaries; filtering an ultrafiltrate of blood from the capillaries by exerting a negative pressure withdrawal force on the porous membrane filter so as to cause the ultrafiltrate to flow from the capillaries through the filter at a desired flow rate; collecting the ultrafiltrate in a reservoir located externally of the body; and assaying the ultrafiltrate to measure a desired physiological constituent thereof.
Claim 3
Dependent Claim
18 words
The method of claim 1 wherein said assaying step includes measuring the level of glucose in the ultrafiltrate.
Claim 4
Dependent Claim
34 words
The method of claim 1 wherein said filtering and collecting steps include filtering the ultrafiltrate along with a gas and collecting the ultrafiltrate inside said reservoir in distinct liquid boluses separated by the gas.
Claim 5
Dependent Claim
37 words
The method of claim 3 wherein said collecting step includes collecting the ultrafiltrate inside said reservoir in distinct liquid boluses separated by the gas in a volume ratio of gas to ultrafiltrate of about ten to one.
Claim 6
Dependent Claim
26 words
The method of claim 1 wherein said filtering step is accomplished at a flow rate in a range from about 20 to 500 microliters per hour.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-10-18 | 1992-04-18 | 1992-10-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-10-18 | 1996-04-18 | 1996-10-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-10-18 | 2000-04-18 | 2000-10-18 | $7700.00 | Window Closed / Lapsed |