US4776850A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Nitrate-containing plaster
Assignee: Beiersdorf AG
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Filing: 1986-05-12
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Granted: 1988-10-11
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Expires: 2006-05-12
Abstract
Abstract A self-adhesive plaster with glycerol trinitrate in a self-adhesive composition of a saturated rubber and a tackifying resin for transdermal administration is characterized in that the saturated rubber comprises a higher-molecular, structure-forming component and a low-molecular, plasticizing component.
Inventors
- 👤 Gunter Guse
- 👤 Bodo Asmussen
- 👤 Johannes Boss
- 👤 Gunter Borchert
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 07:43
CPC Classifications
A; A61; A61L; A61L15/00; A61L15/16; A61L15/22; A61K; A61K9/00; A61K9/70; A61K9/7023; A61K9/703; A61K9/7038; A61K9/7046; A61K9/7053; A61F; A61F13/00; A61F13/02; A61K31/00; A61K31/21; A61K9/7076; A61L15/30
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
114 words
A self-adhesive plastic with glycerol trinitrate for transdermal administration and having a surface for directly contacting the skin of a user, comprising: (a) a carrier film, (b) a layer of glycerol-trinitrate containing self-adhesive composition of a saturated rubber and a tackifying resin, said saturated rubber comprising a high-molecular, structure-forming component and a low-molecular, plasticizing component, said layer having one surface disposed on the carrier film and having an exposed surface constituting the surface of the plaster for directly contacting the skin of a user, and (c) a peel-off protective film on the exposed surface of the layer and removable during use to permit said exposed surface to directly contact the skin of a user.
Claim 2
Dependent Claim
114 words
A self-adhesive plastic with glycerol trinitrate for transdermal administration and having a surface for directly contacting the skin of a user, comprising: (a) a carrier film, (b) a layer of glycerol-trinitrate containing self-adhesive composition of a saturated rubber and a tackifying resin, said saturated rubber comprising a high-molecular, structure-forming component and a low-molecular, plasticizing component, said layer having one surface disposed on the carrier film and having an exposed surface constituting the surface of the plaster for directly contacting the skin of a user, and (c) a peel-off protective film on the exposed surface of the layer and removable during use to permit said exposed surface to directly contact the skin of a user.
Claim 3
Dependent Claim
42 words
The plaster according to claim 1, wherein the saturated rubber comprises 85-40% by weight of a higher-molecular, structure-forming component having a mean molecular weight of 2,400,000-3,200,000 and 15-60% by weight of a low-molecular, plasticizing component having a mean molecular weight of 30,000-50,000.
Claim 4
Dependent Claim
28 words
The plaster according to claim 2, wherein the saturated rubber comprises 55-45% by weight of the higher-molecular, structure-forming component and 45-55% by weight of the low-molecular, plasticizing component.
Claim 5
Dependent Claim
40 words
The plaster according to claim 2 or 3, wherein the higher-molecular, structure-forming component of the saturated rubber has a mean molecular weight of 2,800,000 and the low-molecular, plasticizing component of the saturated rubber has a mean molecular weight of 40,000.
Claim 6
Dependent Claim
12 words
The plaster according to claim 1, wherein the saturated rubber is polyisobutylene.
Claim 7
Dependent Claim
17 words
The plaster according to claim 1 or 5, wherein the tackifying resin is an aliphatic hydrocarbon resin.
Claim 8
Dependent Claim
24 words
The plaster according to claim 1, wherein the self-adhesive composition contains 40-70% by weight of saturated rubber and 60-30% by weight of tackifying resin.
Claim 9
Dependent Claim
24 words
The plaster according to claim 7, wherein the self-adhesive composition contains 45-55% by weight of saturated rubber and 55-45% by weight of tackifying resin.
Claim 10
Dependent Claim
16 words
The plaster according to claim 1, wherein the glycerol trinitrate is present together with a stabilizer.
Claim 11
Dependent Claim
22 words
The plaster according to claim 9, wherein the glycerol trinitrate is present together with 90-95% by weight of lactose as the stabilizer.
Claim 12
Dependent Claim
23 words
The plaster according to claim 1, wherein the self-adhesive composition containing glycerol trinitrate is applied in a quantity of 100-500 g/m 2 .
Claim 13
Dependent Claim
23 words
The plaster according to claim 1, wherein the self-adhesive composition containing glycerol trinitrate is applied in a quantity of 200-400 g/m 2 .
Claim 14
Dependent Claim
21 words
The plaster according to claim 1, wherein an individual plaster of 16 cm 2 size contains 20-40 mg of glycerol trinitrate.
Claim 15
Dependent Claim
22 words
The plaster according to claim 1, wherein at least one of the carrier and peel-off protective film consist of an impermeable film.
Claim 16
Dependent Claim
15 words
The plaster according to claim 14, wherein the impermeable film comprises a metallized plastic film.
References Cited (Backward Citations)
US3797494A
Cited
US3964482A
Cited
US3742951A
Cited
US3742951B1
Cited
US4201211A
Cited
US4291015A
Cited
US4286592A
Cited
US4421737A
Cited
US4314557A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-10-11 | 1992-04-11 | 1992-10-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-10-11 | 1996-04-11 | 1996-10-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-10-11 | 2000-04-11 | 2000-10-11 | $7700.00 | Window Closed / Lapsed |