US4775625A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Inactivating enveloped viruses with a merocyanine dye
Assignee: Medical College of Wisconsin
•
Filing: 1986-11-21
•
Granted: 1988-10-04
•
Expires: 2006-11-21
Abstract
Abstract A method of inactivating viruses comprises bringing the viruses into contact with an effective amount of a photosensitizing agent which will bind to the viruses and/or virus infected cells, and then exposing the resulting mixture to visible light to excite and inactivate the viruses.
Inventors
- 👤 Fritz Sieber
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 14:24
CPC Classifications
A; A61; A61K; A61K39/00; A61K39/12; A61K39/245; A61K31/00; A61K31/33; A61K31/395; A61K31/495; A61K31/505; A61K31/513; A61K31/515; A61K39/21; A61L; A61L2/00; A61L2/02; A61L2/08; A61M; A61M1/00; A61M1/36; A61M1/3681; A61M1/3683; A61M1/3686; C; C12; C12N; C12N7/00; A61K2039/51; A61K2039/525; A61K2039/5252; A61L2103/00; A61L2103/05; C12N2710/00; C12N2710/00011; C12N2710/16011; C12N2710/16611; C12N2710/16634; C12N2710/16661; C12N2710/16663; C12N2740/00; C12N2740/00011; C12N2740/10011; C12N2740/14011; C12N2740/14034
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
68 words
The method of inactivating an enveloped virus which comprises first bringing said enveloped virus into contact with an effective amount of a photosensitizing agent to inactivate said virus, said agent being a merocyanine dye which selectively binds to said virus and then exposing the combination of the virus and agent to visible light of sufficient strength for a sufficient period of time to photosensitize and inactive the virus.
Claim 2
Independent Claim
68 words
The method of inactivating an enveloped virus which comprises first bringing said enveloped virus into contact with an effective amount of a photosensitizing agent to inactivate said virus, said agent being a merocyanine dye which selectively binds to said virus and then exposing the combination of the virus and agent to visible light of sufficient strength for a sufficient period of time to photosensitize and inactive the virus.
Claim 3
Dependent Claim
123 words
The method of claim 1 in which the merocyanine dye is a compound of the following formula: ##STR4## in which n is 1-5; X is oxygen, sulphur, --CR 1 R 2 --, or selenium; Y is O or S; M is an alkaline metal basic group; R 1 and R 2 are the same or different alkyl groups of 1 to 8 carbons; and R 3 , R 4 , R 5 and R 6 are selected from hydrogen, lower alkyl groups of 1 to 5 carbons, lower alkoxy groups of 1 to 5 carbons, phenyl lower alkyls; and an aromatic ring formed by R 3 and R 4 , or R 4 and R 5 or R 5 and R 6 .
Claim 4
Dependent Claim
20 words
A method of claim 1 in which the merocyanine dye is selected from the group consisting of the following: ##STR5##
Claim 5
Independent Claim
69 words
A method of inactivating an enveloped vircus without affecting its usefulness in making a vaccine whyich comprises bringing the virus into contact with an effective amount of a merocyanine dye photosensitizing agent to inactivate the virus and then subjecting the virus and photosensitizing agent to an effective amount of visible light for a sufficient length of time to inactivate the virus without affecting its usefulness in making a vaccine.
Claim 6
Independent Claim
69 words
A method of inactivating an enveloped vircus without affecting its usefulness in making a vaccine whyich comprises bringing the virus into contact with an effective amount of a merocyanine dye photosensitizing agent to inactivate the virus and then subjecting the virus and photosensitizing agent to an effective amount of visible light for a sufficient length of time to inactivate the virus without affecting its usefulness in making a vaccine.
Claim 7
Independent Claim
66 words
A method treating a disease which is caused by an enveloped virus, which disease results in lesions, said method comprising forming a combination of the enveloped virus in the lesions and an effective amount of a merocyanine dye photosensitizing agent to inactivate the virus and then exposing the combination to an effective amount of visible light for a sufficient length of time to inactivate said virus.
Claim 8
Independent Claim
66 words
A method treating a disease which is caused by an enveloped virus, which disease results in lesions, said method comprising forming a combination of the enveloped virus in the lesions and an effective amount of a merocyanine dye photosensitizing agent to inactivate the virus and then exposing the combination to an effective amount of visible light for a sufficient length of time to inactivate said virus.
References Cited (Backward Citations)
US4424201A
Cited
US4321919A
Cited
US4398906A
Cited
US4428744A
Cited
US4464166A
Cited
EP0124363A2
Cited
US4568328A
Cited
US4573960A
Cited
US4573962A
Cited
US4573961A
Cited
US4578056A
Cited
US4596547A
Cited
US4623328A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-10-04 | 1992-04-04 | 1992-10-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-10-04 | 1996-04-04 | 1996-10-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-10-04 | 2000-04-04 | 2000-10-04 | $7700.00 | Window Closed / Lapsed |