US4774326A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Process for preparing N-glycolylneuraminic acid derivatives
Assignee: Mect Corp
•
Filing: 1986-10-10
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Granted: 1988-09-27
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Expires: 2006-10-10
Abstract
Abstract This invention provides a novel process for preparing a compound represented by the formula ##STR1## In accordance with this invention, the compound is prepared by reacting a compound represented by the formula ##STR2## with glycolic acid in the presence of dicyclohexylcarbodiimide. The compound (2) is a useful precursor for the preparation of N-glycolylneuraminic acid: ##STR3##
Inventors
- 👤 Shohei Shibayama
- 👤 Shoji Yoshimura
- 👤 Masayoshi Ito
- 👤 Yoshiyasu Shitori
- 👤 Tomoya Ogawa
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 23:18
CPC Classifications
C; C07; C07H; C07H15/00; C07H15/02; C07H15/04
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
63 words
A process for preparing a compound represented by the formula ( 2) ##STR11## which comprises reacting a compound represented by the formula (1) ##STR12## with a glycolic acid in the presence of dicyclohexylcarbodiimide and a solvent, wherein said solvent is selected from the group consisting of methylene chloride, acetonitrile, N,N'-dimethylformamide, pyridine, and tetrahydrofuran, at a temperature of from -10° C. to 25° C.
Claim 2
Dependent Claim
63 words
A process for preparing a compound represented by the formula ( 2) ##STR11## which comprises reacting a compound represented by the formula (1) ##STR12## with a glycolic acid in the presence of dicyclohexylcarbodiimide and a solvent, wherein said solvent is selected from the group consisting of methylene chloride, acetonitrile, N,N'-dimethylformamide, pyridine, and tetrahydrofuran, at a temperature of from -10° C. to 25° C.
Claim 3
Dependent Claim
12 words
The process of claim 1 wherein the solvent is pyridine or dimethylformamide.
Claim 4
Dependent Claim
27 words
The process of any one of claims 1 or 2 wherein the reaction is carried out in the presence of N-hydroxy-5-norbornene-2,3-dicarboximide and N-ethylmorpholine in addition to dicyclohexylcarbodiimide.
Claim 5
Dependent Claim
22 words
The process of claim 1 wherein the glycolic acid is HO 13 CH 2 13 COOH and a reaction product is ##STR13##
Claim 6
Dependent Claim
12 words
The process of claim 4 wherein the solvent is pyridine or dimethylformamide.
Claim 7
Dependent Claim
27 words
The process of any one of claims 4 or 5 wherein the reaction is carried out in the presence of N-hydroxy-5-norbornene-2,3-dicarboximide and N-ethylmorpholine in addition to dicyclohexylcarbodiimide.
References Cited (Backward Citations)
GB2101588A
Cited
US4593091A
Cited
US4694076A
Cited
US4691012A
Cited
US4663443A
Cited
US4675391A
Cited
EP0219070A2
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-09-27 | 1992-03-28 | 1992-09-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-09-27 | 1996-03-28 | 1996-09-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-09-27 | 2000-03-28 | 2000-09-27 | $7700.00 | Window Closed / Lapsed |