US4774320A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Synthetic peptide with human interleukin 1 activity
Assignee: Sclavo SpA
•
Filing: 1986-10-20
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Granted: 1988-09-27
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Expires: 2006-10-20
Abstract
Abstract Synthetic peptide with human interleukin 1 activity, which peptide can be used as a stimulant of the immune functions and can be defined by the general formula: Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys-X (I) where: Val=L-valine; Gln=L-glutamine; Gly=glycine; Glu=L-glutamic acid; Ser=L-serine; Asn=L-asparagine; Asp=L-aspartic acid; Lys=L-lysine; X=cysteine (Cys), OH, NH 2 , a benzyl ester or an alkyl ester group having a number of carbon atoms from 1 to 7.
Inventors
- 👤 Aldo Tagliabue
- 👤 Guido Antoni
- 👤 Rivo Presentini
- 👤 Diana Boraschi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 05:28
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/52; C07K14/54; C07K14/545; A; A61; A61P; A61P37/00; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/14; Y10S930/141
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
77 words
A synthetic peptide having human interleukin 1 activity and being useful as a stimulant of the immune system, said peptides having the formula: Val-Gin-Gly-Glu-Glu-Ser-Asn-Asp-Lys-X (I) wherein Val is L-valine; Gln is L-glutamine; Gly is glycine; Glu is L-glutamic acid; Ser is L-serine; Asn is L-asparagine; Asp is L-aspartic acid; Lys is L-Lysine; and X is selected from L-cysteine (Cys), OH, NH 2 , a benzyl ester and an alkyl ester having from 1 to 7 carbon atoms.
Claim 2
Dependent Claim
77 words
A synthetic peptide having human interleukin 1 activity and being useful as a stimulant of the immune system, said peptides having the formula: Val-Gin-Gly-Glu-Glu-Ser-Asn-Asp-Lys-X (I) wherein Val is L-valine; Gln is L-glutamine; Gly is glycine; Glu is L-glutamic acid; Ser is L-serine; Asn is L-asparagine; Asp is L-aspartic acid; Lys is L-Lysine; and X is selected from L-cysteine (Cys), OH, NH 2 , a benzyl ester and an alkyl ester having from 1 to 7 carbon atoms.
Claim 3
Dependent Claim
10 words
The synthetic peptide of claim 1, having the formula: Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys-OH.
Claim 4
Dependent Claim
10 words
The synthetic peptide of claim 1 having the formula: Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys-NH.sub.2.
Claim 5
Dependent Claim
10 words
The synthetic peptide of claim 1 having the formula: Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys-Cys.
Claim 6
Dependent Claim
22 words
A pharmaceutical composition comprising a therapeutically effective amount of the synthetic peptide of claim 1 in combination with a pharmaceutically acceptable carrier.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-09-27 | 1992-03-28 | 1992-09-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-09-27 | 1996-03-28 | 1996-09-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-09-27 | 2000-03-28 | 2000-09-27 | $7700.00 | Window Closed / Lapsed |