US4772685A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Immunogenic peptides of human interleukin-1 and the corresponding anti-peptide antibodies
Assignee: Merck and Co Inc
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Filing: 1985-10-02
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Granted: 1988-09-20
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Expires: 2005-10-02
Abstract
Abstract Several distinct peptide regions of the secreted form of purified human interleukin-1 species pI 6.8 have been found to exhibit characteristics associated with highly immunogenic protein moieties and are used to produce specific anti-peptide antibodies. The antibodies raised against the individual peptides are specific for the peptide used for their production and for IL-1, pI 6.8. The individual antibodies bind to both the precursor of IL-1, pI 6.8 and the mature or extracellular IL-1, pI 6.8.
Inventors
- 👤 John A. Schmidt
- 👤 Joshua S. Boger
- 👤 Ellen B. K. Bayne
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 12:53
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/68; G01N33/6863; G01N33/6869; C; C07; C07K; C07K14/00; C07K14/435; C07K14/52; C07K14/54; C07K14/545; C07K16/00; C07K16/18; C07K16/24; C07K16/244; C07K16/245; Y; Y10; Y10S; Y10S530/00; Y10S530/806; Y10S530/81; Y10S530/812; Y10S930/00; Y10S930/01; Y10S930/14; Y10S930/141
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
35 words
A peptide having the amino acid sequence CYS GLN LEU GLU SER VAL ASP PRO LYS ASN TYR PRO LYS LYS LYS MET GLU LYS ARG PHE or the amide or acid addition salts thereof.
Claim 2
Dependent Claim
35 words
A peptide having the amino acid sequence CYS GLN LEU GLU SER VAL ASP PRO LYS ASN TYR PRO LYS LYS LYS MET GLU LYS ARG PHE or the amide or acid addition salts thereof.
Claim 3
Dependent Claim
17 words
A peptide immunogen comprising the peptide of claim 1 conjugated to a high molecular weight carrier protein.
Claim 4
Dependent Claim
17 words
The peptide immunogen of claim 2 wherein the high molecular weight carrier protein is keyhole limpet hemocyanin.
Claim 5
Dependent Claim
26 words
A method of producing antibodies to the peptide immunogen of claim 2 comprising the immunization of animals with the peptide immunogen combined with an acceptable adjuvant.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-09-20 | 1992-03-21 | 1992-09-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-09-20 | 1996-03-21 | 1996-09-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-09-20 | 2000-03-21 | 2000-09-20 | $7700.00 | Window Closed / Lapsed |