US4769121A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Sintered pellet with biochemically active layer
Assignee: Biotronic Systems Corp
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Filing: 1987-05-01
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Granted: 1988-09-06
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Expires: 2007-05-01
Abstract
Abstract A sintered powder electrode has a biochemically active layer embedded in pores of the electrode. Molecules bind to or are displaced from the biochemically active layer, which drastically changes electrical properties of the electrode. The electrode can be used in an affinity chromotography column or in a capacitive affinity sensor.
Inventors
- 👤 Arnold L. Newman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 20:50
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/543; G01N33/54366; G01N33/54373; G01N33/5438; G01N27/00; G01N27/26; G01N27/28; G01N27/30; G01N27/327; G01N27/3275; G01N27/3276; G01N30/00; G01N30/02; G01N2030/022; G01N2030/027; G01N30/50
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
36 words
An apparatus comprising: an electrode having a body with pores that interconnect; a passivating layer over the body; and a biochemically active layer immobilized on the passivating layer and embedded in the pores of the body.
Claim 2
Independent Claim
36 words
An apparatus comprising: an electrode having a body with pores that interconnect; a passivating layer over the body; and a biochemically active layer immobilized on the passivating layer and embedded in the pores of the body.
Claim 3
Dependent Claim
19 words
The apparatus of claim 1, the biochemically active layer comprising receptor molecules extending from a surface of the pores.
Claim 4
Dependent Claim
11 words
The apparatus of claim 2, the body comprising a sintered material.
Claim 5
Dependent Claim
17 words
The apparatus of claim 2, the receptor molecules comprising a means for directly binding with analyte molecules.
Claim 6
Dependent Claim
29 words
The apparatus of claim 4, the electrode comprising one electrode of a capacitive affinity sensor, and the biochemically active layer comprising a dielectric material of the capacitive affinity sensor.
Claim 7
Dependent Claim
24 words
The apparatus of claim 2, the biochemically active layer also comprising a means for competitively binding with the receptor molecules and an analyte molecule.
Claim 8
Dependent Claim
29 words
The apparatus of claim 6, the electrode comprising one electrode of a capacitive affinity sensor, and the biochemically active layer comprising a dielectric material of the capacitive affinity sensor.
Claim 9
Independent Claim
85 words
A method comprising: applying a passivating layer over an electrode having pores that connect through the electrode; immobilizing a biochemically active layer on the passivating layer and embedding the biochemically active layer into the pores of the electrode; introducing into the pores of the electrode a fluid having analyte molecules that are biospecific to the biochemically active layer and which biochemically affect the biochemically active layer; and determining a change in electrical properties of the electrode as the analyte molecules affect the biochemically active layer.
Claim 10
Independent Claim
85 words
A method comprising: applying a passivating layer over an electrode having pores that connect through the electrode; immobilizing a biochemically active layer on the passivating layer and embedding the biochemically active layer into the pores of the electrode; introducing into the pores of the electrode a fluid having analyte molecules that are biospecific to the biochemically active layer and which biochemically affect the biochemically active layer; and determining a change in electrical properties of the electrode as the analyte molecules affect the biochemically active layer.
Claim 11
Dependent Claim
21 words
The method of claim 8 comprising immobilizing a receptor molecule on the passivating layer as part of the biochemically active layer.
Claim 12
Dependent Claim
21 words
The method of claim 9 comprising relating electrical conductivity of the electrode to a concentration of analyte molecules in the fluid.
Claim 13
Dependent Claim
13 words
The method of claim 10 comprising sintering a material to form the electrode.
Claim 14
Dependent Claim
20 words
The method of claim 11 comprising forming the biochemically active layer with molecules that bind directly with the analyte molecules.
Claim 15
Dependent Claim
20 words
The method of claim 11 comprising forming the biochemically active layer with molecules that bind competitively with the analyte molecules.
References Cited (Backward Citations)
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US4453126A
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US4236893A
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US4615983A
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US4434236A
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US4571543A
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-09-06 | 1992-03-07 | 1992-09-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-09-06 | 1996-03-07 | 1996-09-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-09-06 | 2000-03-07 | 2000-09-06 | $7700.00 | Window Closed / Lapsed |