US4768513A
Expired / Lapsed
US
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Method and device for measuring and processing light
Assignee: National Institute of Advanced Industrial Science and Technology
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Filing: 1987-03-30
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Granted: 1988-09-06
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Expires: 2007-03-30
Abstract
Abstract A method and device for measuring and processing light whereby laser light is irradiated onto positions of an organism which has been injected with a fluorescent substance having a strong affinity for tumors, the fluorescence and the reflected light produced by this irradiation are detected, and the detected intensity of the fluorescence is calculated and analyzed by means of the intensity of the reflected light.
Inventors
- 👤 Susumu Suzuki
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 13:21
CPC Classifications
G; G01; G01N; G01N21/00; G01N21/62; G01N21/63; G01N21/64; G01N21/6428; A; A61; A61B; A61B5/00; A61B5/0059; A61B5/0071; A61B5/0075; A61B5/0082; A61B5/0084; A61N; A61N5/00; A61N5/06; A61N5/0601; A61N5/0613; A61N5/062; A61B1/00; A61B1/04; A61B1/043; G01N2021/6417; G01N21/645; G01N2021/6484; G01N21/6456
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
72 words
A method for measuring light, comprising the steps of: injecting an organism with a fluorescent substance having a strong affinity for tumors, irradiating predetermined positions of said organism with laser light to excite fluorescence and allow said laser light to reflect from said predetermined positions of said organism, detecting said fluorescence and reflected light, and calculating and analyzing the intensity of the detected fluorescence based on the intensity of the detected light.
Claim 2
Independent Claim
72 words
A method for measuring light, comprising the steps of: injecting an organism with a fluorescent substance having a strong affinity for tumors, irradiating predetermined positions of said organism with laser light to excite fluorescence and allow said laser light to reflect from said predetermined positions of said organism, detecting said fluorescence and reflected light, and calculating and analyzing the intensity of the detected fluorescence based on the intensity of the detected light.
Claim 3
Dependent Claim
25 words
A method according to claim 1, wherein said fluorescent substance is a hematoporphyrin derivative and said laser light has a wavelength of about 405 nm.
Claim 4
Independent Claim
76 words
A device for measuring light, comprising: a light-irradiating means for irradiating with laser light predetermined positions of an organism injected with a fluorescent substance having a strong affinity for tumors, a light-detecting means for detecting fluorescence excited by the irradiation of said laser light and laser light reflected by said predetermined positions of said organism, and an analyzer means for calculating and analyzing the intensity of said fluorescence based on the intensity of said reflected light.
Claim 5
Independent Claim
76 words
A device for measuring light, comprising: a light-irradiating means for irradiating with laser light predetermined positions of an organism injected with a fluorescent substance having a strong affinity for tumors, a light-detecting means for detecting fluorescence excited by the irradiation of said laser light and laser light reflected by said predetermined positions of said organism, and an analyzer means for calculating and analyzing the intensity of said fluorescence based on the intensity of said reflected light.
Claim 6
Dependent Claim
28 words
A device according to claim 3, wherein said light-irradiating means comprises a light source for said laser light and a first light guide for transmitting this laser light.
Claim 7
Dependent Claim
67 words
A device according to claim 3, wherein said light-detecting means comprises a second light guide for transmitting the reflected light and fluorescence output from the organism, a spectroscopic means for dividing the light transmitted from said second light guide into fluorescence and laser light and outputting them as spectral images, and a pickup means for picking up said spectral images and outputting them as spectral video signals.
Claim 8
Dependent Claim
89 words
A device according to claim 3, wherein said light-irradiating means comprises a light source for said laser light and a first light guide for transmitting said laser light, and said light-detecting means comprises a second light guide for transmitting the reflected light and fluorescence output from said organism, a spectroscopic means for dividing the light transmitted from said second light guide into fluorescence and laser light and outputting them as spectral images, and a pickup means for picking up said spectral images and outputting them as spectral video signals.
Claim 9
Dependent Claim
53 words
A device according to claim 6, wherein said first light guide has a first polarizing filter mounted at its tip, and said second light guide has a second polarizing filter mounted at its tip so as to have a polarizing direction which is orthogonal to the polarizing direction of said first light guide.
Claim 10
Dependent Claim
82 words
A device according to claim 3, wherein said analyzer means is adapted to receive input of spectral video signals, normalize the amplitudes of said signals by arithmetic processing on the basis of information contained in said signals on the intensity of the reflected light, convert the normalized amplitudes into graphic images, display fluorescence spectrum patterns on a monitor and, when said reflected light has dropped below a first standard value or has risen above a second standard value, also display this information.
Claim 11
Independent Claim
106 words
A method for measuring and processing light, comprising the steps of: injecting an organism with a fluorescent substance having a strong affinity for tumors, irradiating predetermined positions of said organism with first laser light to excite fluorescence and allow said first laser light to reflect from said predetermined positions of said organism, detecting said fluorescence and reflected light, and calculating and analyzing the intensity of the detected fluorescence based on the intensity of the detected light and, depending on the calculated and analyzed results, irradiating said predetermined positions of said organism with a second laser light to perform processing of said predetermined positions of said organism.
Claim 12
Independent Claim
106 words
A method for measuring and processing light, comprising the steps of: injecting an organism with a fluorescent substance having a strong affinity for tumors, irradiating predetermined positions of said organism with first laser light to excite fluorescence and allow said first laser light to reflect from said predetermined positions of said organism, detecting said fluorescence and reflected light, and calculating and analyzing the intensity of the detected fluorescence based on the intensity of the detected light and, depending on the calculated and analyzed results, irradiating said predetermined positions of said organism with a second laser light to perform processing of said predetermined positions of said organism.
Claim 13
Dependent Claim
26 words
A method according to claim 9, wherein said fluorescent substance is a hematoporphyrin derivative, and said first laser light has a wavelength of about 405 nm.
Claim 14
Independent Claim
104 words
A device for measuring and processing light, comprising: a light-irradiating means for irradiating with first laser light predetermined positions of an organism injected with a fluorescent substance having a strong affinity for tumors, a light-detecting means for detecting fluorescence excited by the irradiation of said first laser light and first laser light reflected by said predetermined positions of said organism, an analyzer means for calculating and analyzing the intensity of said fluorescence based on the intensity of said reflected light, and a second irradiating means for irradiating said predetermined positions of said organism with second laser light depending on the calculated and analyzed results.
Claim 15
Independent Claim
104 words
A device for measuring and processing light, comprising: a light-irradiating means for irradiating with first laser light predetermined positions of an organism injected with a fluorescent substance having a strong affinity for tumors, a light-detecting means for detecting fluorescence excited by the irradiation of said first laser light and first laser light reflected by said predetermined positions of said organism, an analyzer means for calculating and analyzing the intensity of said fluorescence based on the intensity of said reflected light, and a second irradiating means for irradiating said predetermined positions of said organism with second laser light depending on the calculated and analyzed results.
Claim 16
Dependent Claim
31 words
A device according to claim 11, wherein said first light-irradiating means comprises a light source for said first laser light and a first light guide for transmitting said first laser light.
Claim 17
Dependent Claim
67 words
A device according to claim 11, wherein said light-detecting means comprises a second light guide for transmitting the reflected light and fluorescence output from said organism, a spectroscopic means for dividing the light transmitted from said second light guide into fluorescence and laser light and outputting them as spectral images, and a pickup means for picking up said spectral images and outputting them as spectral video signals.
Claim 18
Dependent Claim
92 words
A device according to claim 11, wherein said first light-irradiating means comprises a light source for said first laser light and a first light guide for transmitting said first laser light, and said light-detecting means comprises a second light guide for transmitting the reflected light and fluorescence output from said organism, a spectroscopic means for dividing the light transmitted from said second light guide into fluorescence and laser light and outputting them as spectral images, and a pickup means for picking up said spectral images and outputting them as spectral video signals.
Claim 19
Dependent Claim
53 words
A device according to claim 14, wherein said first light guide has a first polarizing filter mounted at its tip, and said second light guide has a second polarizing filter mounted at its tip so as to have a polarizing direction which is orthogonal to the polarizing direction of said first light guide.
Claim 20
Dependent Claim
83 words
A device according to claim 11, wherein said analyzer means is adapted to receive input of spectral video signals, normalize the amplitudes of said signals by arithmetic processing on the basis of information contained in said signals on the intensity of the reflected light, convert the normalized amplitudes into graphic images, display fluorescence spectrum wave patterns on a monitor and, when said reflected light has dropped below a first standard value or has risen above a second standard value, also display this information.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1991-09-06 | 1992-03-07 | 1992-09-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-09-06 | 1996-03-07 | 1996-09-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-09-06 | 2000-03-07 | 2000-09-06 | $7700.00 | Window Closed / Lapsed |