US4766381A — Driven inversion spin echo magnetic resonance ima…

Claim 1

Independent Claim 228 words

A method of inversion spin echo magnetic resonance imaging including providing a specimen disposed within a main magnetic field, a source of pulsed RF signals, receiver means for receiving signals from said specimen responsive to said RF pulses and emitting responsive output signals, computer means for receiving said output signals from said receiver means and establishing image information related thereto and visual display means for displaying images from said image information, during an initial echo period imposing three pulses on said main magnetic field with the first and third said pulses having a first value and the second said pulse having a second value substantially larger than said first value, creating a first echo with said second pulse, converting said first echo into negative longitudinal magnetization by said third pulse, after an inversion recovery period, during a second echo period imposing fourth and fifth pulses on said main magnetic field in the same sequence as said first and second pulses, respectively, creating a second spin echo with said fifth pulse, responsive to the said spin echo, emitting said output signals from said receiver means to said computer means, responsive to receipt of said output signals by said computer means, emitting image information directly or indirectly from said computer means to said visual display means, whereby said visual display means will display the image obtained from said echo pulse.

Claim 2

Independent Claim 228 words

A method of inversion spin echo magnetic resonance imaging including providing a specimen disposed within a main magnetic field, a source of pulsed RF signals, receiver means for receiving signals from said specimen responsive to said RF pulses and emitting responsive output signals, computer means for receiving said output signals from said receiver means and establishing image information related thereto and visual display means for displaying images from said image information, during an initial echo period imposing three pulses on said main magnetic field with the first and third said pulses having a first value and the second said pulse having a second value substantially larger than said first value, creating a first echo with said second pulse, converting said first echo into negative longitudinal magnetization by said third pulse, after an inversion recovery period, during a second echo period imposing fourth and fifth pulses on said main magnetic field in the same sequence as said first and second pulses, respectively, creating a second spin echo with said fifth pulse, responsive to the said spin echo, emitting said output signals from said receiver means to said computer means, responsive to receipt of said output signals by said computer means, emitting image information directly or indirectly from said computer means to said visual display means, whereby said visual display means will display the image obtained from said echo pulse.

Claim 3

Dependent Claim 16 words

The method of claim 1 including establishing said first pulse at about 70 to 110 degrees.

Claim 4

Dependent Claim 22 words

The method of claim 2 including repeating said five-pulse cycle a predetermined number of times in order to generate additional image information.

Claim 5

Dependent Claim 37 words

The method of claim 3 including establishing said first and third pulses at approximately 90 degrees, establishing said second and fifth pulses at approximately 180 degrees and establishing said fourth pulse between about 10 and 170 degrees.

Claim 6

Dependent Claim 37 words

The method of claim 4 including delaying initiation of a first said pulse in the next subsequent cycle of operation after said second spin echo in the next preceding cycle of operation by a predetermined time period.

Claim 7

Dependent Claim 195 words

The method of claim 5 wherein establishing the image information obtained from said spin echo by the following relationship: ##EQU3## wherein: I=the actual pixel intensity, N=density of sensitive nuclear spins in the sample, K=a scale factor based on electronics, slice thickness and the like, KN=the theoretical pixel intensity in the absence of RF pulses, T 1 =T 1 relaxation, T 2 =T 2 relaxation, TD=the delay time from the peak of the acquired echo to the initiation of a new cycle initiated by a 90 degrees pulse i.e., the delay time necessary for T 1 recovery in order for another cycle to be initiated, TI=the inversion time i.e., the time from the middle of the second 90 degree pulse of the inversion pulse triplet that starts each sequence to the middle of the 90 degree pulse which begins the reading event, TE 1 =the echo time from the middle of the initiating 90 degree pulse to the peak of the spin echo which is converted to inverted longitudinal magnetization, and TE 2 =the echo time from the middle of the 90 degree pulse beginning the reading event to the peak of the resultant spin echo.

Claim 8

Dependent Claim 19 words

The method of claim 5 establishing the said first echo period aproximately equal to the T 2 relaxation period.

Claim 9

Dependent Claim 43 words

The method of claim 7 including establishing the time relationships between said T 2 relaxation period and said second echo time period TE 2 such that TE 2 is much shorter than T 2 and preferably less than 0.25 times T 2 .

Claim 10

Dependent Claim 21 words

The method of claim 6 establishing the duration of said inversion time TI approximately equal to said T 1 relaxation period.

Claim 11

Dependent Claim 32 words

The method of claim 9 establishing the time relationship between said repetition time TD and said T 1 relaxation period such that TD is about 2.5 to 4.0 times T 1 .

Claim 12

Dependent Claim 19 words

The method of claim 1 including said first through fifth pulses applied generally perpendicularly to said main magnetic field.

Claim 13

Dependent Claim 32 words

The method of claim 4 including employing as a frame of reference X-Y-Z axis coordinates, establishing said main magnetic field on said Z-axis, and establishing a magnetic field gradient along said Z-axis.

Claim 14

Dependent Claim 21 words

The method of claim 12 including imposing between said fourth pulse and the subsequent echo a gradient pulse along said Y-axis.

Claim 15

Dependent Claim 22 words

The method of claim 13 including varying the strength of said Y-axis magnetic field gradient in subsequent repetitions of said five-pulse cycle.

Claim 16

Dependent Claim 38 words

The method of claim 12 including prior to said fifth pulse, imposing a magnetic field gradient of positive polarity on said X-axis, or after the fifth pulse imposing a magnetic field gradient of negative polarity on said X-axis.

Claim 17

Dependent Claim 29 words

The method of claim 12 including after said fifth pulse imposing a magnetic field gradient of positive polarity on said X-axis generally throughout the duration of said spin echo.

Claim 18

Dependent Claim 23 words

The method of claim 16 including establishing said X-axis gradient and said Y-axis gradient when the slice selective RF pulses are not on.

Claim 19

Dependent Claim 16 words

The method of claim 17 including maintaining said Z-axis gradient during said fourth and fifth pulses.

Claim 20

Dependent Claim 27 words

The method of claim 4 including creating said first, third and fourth pulses in phase, and creating said second and fifth pulses 90 degrees out of phase.

Claim 21

Dependent Claim 25 words

The method of claim 1 including prior to delivering said image information from said computer means to said visual display means, storing said image information.

Claim 22

Dependent Claim 23 words

The method of claim 16 including employing said X-axis as the frequency encoding axis, and employing said Y-axis as the phase encoding axis.

Claim 23

Dependent Claim 12 words

The method of claim 21 including employing a patient as said specimen.

Claim 24

Dependent Claim 29 words

The method of claim 1 including performing Fourier Transformations on said output signals to convert amplitude versus time data into amplitude versus frequency data in creating said image information.

Claim 25

Dependent Claim 208 words

Apparatus for inversion spin echo magnetic resonance imaging comprising magnetic field generating means for establishing a main magnetic field on a specimen, magnetic field gradient generating means for establishing gradients in said main magnetic field strength, RF signal generating means for emitting pulsed RF signals to at least portions of said magnetic field passing through said specimen, said RF signal generating means having means for generating first, and third pulses of a first value and a second pulse of second value substantially larger than said first value with said second pulse creating a first echo, said RF signal generating means having means for generating fourth and fifth pulses on said main magnetic field in the same general sequence as said first and second pulses and thereby creating a spin echo with said fifth pulse, receiver means for receiving signals emitted from said specimen responsive to said RF pulses and emitting responsive output signals, computer means for receiving said output signals from said receiver means and establishing image information related thereto, and visual display means for displaying images from said image information received from said computer means, whereby said driven inversion spin echo magnetic resonance imaging will be effected with rapid scanning speeds and while maintaining high image contrast.

Claim 26

Dependent Claim 208 words

Apparatus for inversion spin echo magnetic resonance imaging comprising magnetic field generating means for establishing a main magnetic field on a specimen, magnetic field gradient generating means for establishing gradients in said main magnetic field strength, RF signal generating means for emitting pulsed RF signals to at least portions of said magnetic field passing through said specimen, said RF signal generating means having means for generating first, and third pulses of a first value and a second pulse of second value substantially larger than said first value with said second pulse creating a first echo, said RF signal generating means having means for generating fourth and fifth pulses on said main magnetic field in the same general sequence as said first and second pulses and thereby creating a spin echo with said fifth pulse, receiver means for receiving signals emitted from said specimen responsive to said RF pulses and emitting responsive output signals, computer means for receiving said output signals from said receiver means and establishing image information related thereto, and visual display means for displaying images from said image information received from said computer means, whereby said driven inversion spin echo magnetic resonance imaging will be effected with rapid scanning speeds and while maintaining high image contrast.

Claim 27

Dependent Claim 17 words

The apparatus of claim 24 including said computer means controlling operation of said RF signal generating means.

Claim 28

Dependent Claim 24 words

The apparatus of claim 25 including said RF signal generating means having means for establishing said first pulse at about 70 to 110 degrees.

Claim 29

Dependent Claim 22 words

The apparatus of claim 26 including said RF signal generating means having means for establishing said second value at approximately 180 degrees.

Claim 30

Dependent Claim 198 words

The apparatus of claim 25 including said computer means having means for establishing said image information in accordance with the following formula: ##EQU4## wherein: I=the actual pixel intensity, N=density of sensitive nuclear spins in the sample, K=a scale factor based on electronics, slice thickness and the like, KN=the theoretical pixel intensity in the absence of RF pulses, T 1 =T 1 relaxation, T 2 =T 2 relaxation, TD=the delay time from the peak of the acquired echo to the initiation of a new cycle initiated by a 90 degrees pulse i.e., the delay time necessary for T 1 recovery in order for another cycle to be initiated, TI=the inversion time i.e., the time from the middle of the second 90 degree pulse of the inversion pulse triplet that starts each sequence to the middle of the 90 degree pulse which begins the reading event, TE 1 =the echo time from the middle of the initiating 90 degree pulse to the peak of the spin echo which is converted to inverted longitudinal magnetization, and TE 2 =the echo time from the middle of the 90 degree pulse beginning the reading event to the peak of the resultant spin echo.

Claim 31

Dependent Claim 35 words

The apparatus of claim 28 including said RF signal generating means having means for generating said first, third and fourth pulses at approximately 90 degrees and said second and fifth pulses at approximately 180 degrees.

Claim 32

Dependent Claim 30 words

The apparatus of claim 29 including said computer means having means for performing Fourier Transformations on said output signals to convert amplitude versus time data into amplitude versus frequency data.

Claim 33

Dependent Claim 23 words

The apparatus of claim 30 including said computer means having an analog-to-digital converter for converting said receiver means output signals into digitized signals.

Claim 34

Dependent Claim 28 words

The apparatus of claim 28 including said computer means having means for establishing said first echo period with a duration approximately equal to the T 2 relaxation period.

Claim 35

Dependent Claim 43 words

The apparatus of claim 32 including said computer means having means for establishing the relative duration of said second echo period TE 2 with respect to said T 2 relaxation period so that TE 2 is less than 0.25 times T 2 .

Claim 36

Dependent Claim 28 words

The apparatus of claim 33 including said computer means having means for establishing the duration of said inversion time TI approximately equal to said T 1 relaxation period.

Claim 37

Dependent Claim 39 words

The apparatus of claim 34 including said computer means having means for establishing the relative duration of said delay time TD to said T 1 relaxation periods so that TD is about 2.5 to 4.0 times T 1 .

Claim 38

Dependent Claim 23 words

The apparatus of claim 24 including providing X-Y-Z coordinate axes, and gradient generating means for generating magnetic field gradients on each said axis.

Claim 39

Dependent Claim 54 words

The apparatus of claim 36 including said magnetic field generating means adapted to generate said main magnetic field on said Z-axis, and said gradient generating means having means for generating gradients on said X and Y axes prior to or after said RF pulses, whereby spatial information will be provided in said image information.

Claim 40

Dependent Claim 23 words

The apparatus of claim 37 including gradient generating means having means for altering the strength of said gradients with successive cycles of operation.

Claim 41

Dependent Claim 36 words

The apparatus of claim 36 including said gradient generating means and said RF signal generating means cooperating with said computer means and having means for collecting data on more than one slice of said specimen simultaneously.

Claim 42

Dependent Claim 25 words

The apparatus of claim 36 including said computer means having logic means for controlling the timing, signal processing, magnetic fields and gradients and RF pulses.

Claim 43

Independent Claim 253 words

A method of inversion spin echo magnetic resonance imaging including providing a specimen disposed within a main magnetic field, a source of pulsed RF and magnetic gradient signals, receiver means for receiving signals from said specimen responsive to said pulsed signals and emitting responsive output signals, computer means for receiving said output signals from said receiver means and establishing image information related thereto and visual display means for displaying images from said image information, during an initial echo period imposing three pulses on said main magnetic field with the first and third said pulses having a first value and the second said pulse having the effect of an RF pulse of a value substantially larger than said first value, creating a first echo with said second pulse, converting said first echo into negative longitudinal magnetization by said third pulse, employing a said magnetic gradient pulse as at least one of said second and fifth pulses, after an inversion recovery period, during a second echo period imposing fourth and fifth pulses on said main magnetic field in the same sequence as said first and second pulses, respectively, creating a second spin echo with said fifth pulse, responsive to the said spin echo, emitting said output signals from said receiver means to said computer means, responsive to receipt of said output signals by said computer means, emitting image information directly or indirectly from said computer means to said visual display means, whereby said visual display means will display the image obtained from said echo pulse.

Claim 44

Independent Claim 253 words

A method of inversion spin echo magnetic resonance imaging including providing a specimen disposed within a main magnetic field, a source of pulsed RF and magnetic gradient signals, receiver means for receiving signals from said specimen responsive to said pulsed signals and emitting responsive output signals, computer means for receiving said output signals from said receiver means and establishing image information related thereto and visual display means for displaying images from said image information, during an initial echo period imposing three pulses on said main magnetic field with the first and third said pulses having a first value and the second said pulse having the effect of an RF pulse of a value substantially larger than said first value, creating a first echo with said second pulse, converting said first echo into negative longitudinal magnetization by said third pulse, employing a said magnetic gradient pulse as at least one of said second and fifth pulses, after an inversion recovery period, during a second echo period imposing fourth and fifth pulses on said main magnetic field in the same sequence as said first and second pulses, respectively, creating a second spin echo with said fifth pulse, responsive to the said spin echo, emitting said output signals from said receiver means to said computer means, responsive to receipt of said output signals by said computer means, emitting image information directly or indirectly from said computer means to said visual display means, whereby said visual display means will display the image obtained from said echo pulse.

Claim 45

Dependent Claim 18 words

The method of claim 41 including employing said RF pulse signals as said first, second and third pulses.

Claim 46

Dependent Claim 20 words

The method of claim 42 including employing said magnetic gradient pulses as both said second pulse and said fifth pulse.

Claim 47

Dependent Claim 169 words

The method of claim 41 including establishing said image information from the following relationship: ##EQU5## wherein: I=the actual pixel intensity, N=density of sensitive nuclear spins in the sample, K=a scale factor based on electronics, slice thickness and the like, KN=the theoretical pixel intensity in the absence of RF pulses, T 1 =T 1 relaxation, T 2 =T 2 relaxation, TR=the repetition period for the entire cycle i.e. the sum of TE 1 , TI, TE 2 and TD, TI=the inversion time i.e., the time from the middle of the second 90 degree pulse of the inversion pulse triplet that starts each sequence to the middle of the 90 degree pulse which begins the reading event, TE 1 =the echo time from the middle of the initiating 90 degree pulse to the peak of the spin echo which is converted to inverted longitudinal magnetization, and TE 2 =the echo time from the middle of the 90 degree pulse beginning the reading event to the peak of the resultant spin echo.

Claim 48

Dependent Claim 263 words

Apparatus for inversion spin echo magnetic resonance imaging comprising magnetic field generating means for establishing a main magnetic field on a specimen, magnetic field gradient generating means for establishing gradients in said main magnetic field strength, RF signal and magnetic gradient generating means for emitting pulsed RF signals and magnetic gradient signals to at least portions of said magnetic field passing through said specimen, said RF signal and magnetic gradient signal generating means having means for generating first, and third RF pulses of a first value and a second pulse having the effect of an RF pulse of a second value substantially larger than said first value with said second pulse creating a first echo, said RF signal and magnetic gradient generating means having means for generating a fourth RF signal and a fifth pulse having the effect of an RF pulse in the same general sequence as said first and second pulses to create a spin echo with said fifth pulse, receiver means for receiving signals emitted from said specimen responsive to said RF pulses and emitting responsive output signals, computer means for receiving said output signals from said receiver means and establishing image information related thereto, and visual display means for displaying images from said image information received from said computer means, whereby said driven inversion spin echo magnetic resonance imaging will be effected with rapid scanning speeds and while maintaining high image contrast, whereby said first, third and fourth pulses may be RF pulses and at least one of said second and fifth pulses will be a magnetic gradient pulse.

Claim 49

Dependent Claim 263 words

Apparatus for inversion spin echo magnetic resonance imaging comprising magnetic field generating means for establishing a main magnetic field on a specimen, magnetic field gradient generating means for establishing gradients in said main magnetic field strength, RF signal and magnetic gradient generating means for emitting pulsed RF signals and magnetic gradient signals to at least portions of said magnetic field passing through said specimen, said RF signal and magnetic gradient signal generating means having means for generating first, and third RF pulses of a first value and a second pulse having the effect of an RF pulse of a second value substantially larger than said first value with said second pulse creating a first echo, said RF signal and magnetic gradient generating means having means for generating a fourth RF signal and a fifth pulse having the effect of an RF pulse in the same general sequence as said first and second pulses to create a spin echo with said fifth pulse, receiver means for receiving signals emitted from said specimen responsive to said RF pulses and emitting responsive output signals, computer means for receiving said output signals from said receiver means and establishing image information related thereto, and visual display means for displaying images from said image information received from said computer means, whereby said driven inversion spin echo magnetic resonance imaging will be effected with rapid scanning speeds and while maintaining high image contrast, whereby said first, third and fourth pulses may be RF pulses and at least one of said second and fifth pulses will be a magnetic gradient pulse.

Claim 50

Dependent Claim 23 words

The apparatus of claim 45 including said computer means having means for controlling operation of said RF signal and magnetic gradient generating means.

Claim 51

Dependent Claim 177 words

The apparatus of claim 46 including said computer means having means for establishing said image information in accordance with the following formula: ##EQU6## wherein: I=the actual pixel intensity, N=density of sensitive nuclear spins in the sample, K=a scale factor based on electronics, slice thickness and the like, KN=the theoretical pixel intensity in the absence of RF pulses, T 1 =T 1 relaxation, T 2 =T 2 relaxation, TR=the repetition period for the entire cycle i.e. the sum of TE 1 , TI, TE 2 and TD, TI=the inversion time i.e., the time from the middle of the second 90 degree pulse of the inversion pulse triplet that starts each sequence to the middle of the 90 degree pulse which begins the reading event, TE 1 =the echo time from the middle of the initiating 90 degree pulse to the peak of the spin echo which is converted to inverted longitudinal magnetization, and TE 2 =the echo time from the middle of the 90 degree pulse beginning the reading event to the peak of the resultant spin echo.

Annuity Stage	Window Opens	Payment Deadline	Surcharge Period Until	Estimated Fee	Status
3.5 Years (Year 4)	1991-08-23	1992-02-22	1992-08-23	$2000.00	Window Closed / Lapsed
7.5 Years (Year 8)	1995-08-23	1996-02-22	1996-08-23	$3760.00	Window Closed / Lapsed
11.5 Years (Year 12)	1999-08-23	2000-02-22	2000-08-23	$7700.00	Window Closed / Lapsed

Driven inversion spin echo magnetic resonance imaging

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