US4766143A
Expired / Lapsed
US
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Haloalkylthiodibenzothiepins
Assignee: Aventis Pharmaceuticals Inc
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Filing: 1987-02-12
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Granted: 1988-08-23
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Expires: 2007-02-12
Abstract
Abstract Novel aminoalkylthiodibenzothiepins and related compounds, physiologically tolerable acid addition salts thereof, a method of preparing same, pharmaceutical and veterinary preparations including same and methods of treating by administering same are disclosed. These compounds are useful as antidepressant, analgetic, and anticonvulsant agents.
Inventors
- 👤 Helen H. Ong
- 👤 Vernon B. Anderson
- 👤 James A. Profitt
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 17:51
CPC Classifications
C; C07; C07D; C07D337/00; C07D337/02; C07D337/06; C07D337/10; C07D337/14
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
53 words
A compound of the formula ##STR17## wherein X and Y are the same or different and each can be hydrogen, halogen, trifluoromethyl, loweralkoxy, loweralkyl, loweralkanoyl, loweralkylthio, loweralkylsulfonyl, loweralkylsulfinyl, amino, hydroxy or nitro; Z is halogen; and n is an integer of from 2 to 4; or a physiologically tolerable acid addition salt thereof.
Claim 2
Dependent Claim
53 words
A compound of the formula ##STR17## wherein X and Y are the same or different and each can be hydrogen, halogen, trifluoromethyl, loweralkoxy, loweralkyl, loweralkanoyl, loweralkylthio, loweralkylsulfonyl, loweralkylsulfinyl, amino, hydroxy or nitro; Z is halogen; and n is an integer of from 2 to 4; or a physiologically tolerable acid addition salt thereof.
Claim 3
Dependent Claim
18 words
The compound as defined in claim 1 which is 11-(β-bromoethylthio)-2-fluorodibenzo[b,f]thiepin or a physiologically tolerable acid addition salt thereof.
Claim 4
Dependent Claim
31 words
A pharmaceutical composition for treating pain, depression or convulsions which comprises between 0.5 and about 70% by weight of a compound defined in claim 1 and a pharmaceutically acceptable carrier therefor.
Claim 5
Dependent Claim
25 words
A method of treating depression which comprises administering to a patient suffering from depression a pharmaceutically effective amount of a compound defined in claim 1.
Claim 6
Dependent Claim
24 words
A method of treating pain which comprises administering to a patient in pain a pharmaceutically effective amount of a compound defined in claim 1.
Claim 7
Dependent Claim
25 words
A method of treating convulsions which comprises administering to a patient susceptible to convulsions a pharmaceutically effective amount of a compound defined in claim 1.
References Cited (Backward Citations)
US3704245A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-08-23 | 1992-02-22 | 1992-08-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-08-23 | 1996-02-22 | 1996-08-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-08-23 | 2000-02-22 | 2000-08-23 | $7700.00 | Window Closed / Lapsed |