US4762822A
Expired / Lapsed
US
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Reduction of gastrointestinal disease-producing organisms with sialic acid and gangliosides
Assignee: Individual
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Filing: 1985-08-08
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Granted: 1988-08-09
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Expires: 2005-08-08
Abstract
Abstract The present invention discloses mother's milk substitutes containing sialic acid or a ganglioside that reduce the number of gastrointestinal disease-producing organisms in a young mammal's food and gastrointestinal tract. The invention also discloses dietary supplements and methods for reducing the number of gastrointestinal disease-producing organisms.
Inventors
- 👤 Anna C. Ettinger
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 08:18
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/70; A61K31/7004; C; C07; C07H; C07H15/00; C07H15/02; C07H15/04; C07H15/10
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
43 words
An improved food for young mammals comprising a mother's milk substitute in the form of an animal feed or infant formula having N-acetylneuraminic acid or a ganglioside present at about 0.005 to about 0.1 percent of the total weight of the improved food.
Claim 2
Dependent Claim
43 words
An improved food for young mammals comprising a mother's milk substitute in the form of an animal feed or infant formula having N-acetylneuraminic acid or a ganglioside present at about 0.005 to about 0.1 percent of the total weight of the improved food.
Claim 3
Dependent Claim
36 words
The improved food according to claim 1 wherein a ganglioside is present and is selected from the group consisting of mammalian brain ganglioside extract, human milk ganglioside extract, human colostrum ganglioside extract, and ganglioside fraction GD1a.
Claim 4
Dependent Claim
39 words
The improved food according to claim 2 wherein the young mammal is a human infant, the mother's milk substitute is infant formula, and ganglioside is present at about 0.01 to 0.05 percent of the weight of the milk substitute.
Claim 5
Dependent Claim
50 words
The improved food according to claim 2 wherein the infant formula contains about 90 weight percent water, about 1.5 to 2.0 weight percent protein, about 6.8 to about 7.2 weight percent carbohydrate, about 3.6 to 3.8 weight percent fat and about 0.3 to 0.4 weight percent minerals measured as ash.
Claim 6
Dependent Claim
46 words
The improved food according to claim 4 wherein the protein is selected from the group consisting of soy isolate and nonfat milk; the carbohydrate is selected from the group consisting of lactose, sucrose, corn syrup, corn starch, and tapioca dextrin; and said formula additionally contains vitamins.
Claim 7
Dependent Claim
42 words
The improved food according to claim 1 wherein the young mammal is a non-human mammal, the milk substitute is animal feed and N-acetylneuraminic acid or a ganglioside is present at about 0.01 to 0.05 percent of the total weight of the feed.
Claim 8
Dependent Claim
23 words
A dietary supplement comprising a unit dose of N-acetylneuramine acid or a ganglioside present in an effective amount in a physiologically tolerable excipient.
Claim 9
Dependent Claim
23 words
A dietary supplement comprising a unit dose of N-acetylneuramine acid or a ganglioside present in an effective amount in a physiologically tolerable excipient.
Claim 10
Dependent Claim
37 words
The supplement according to claim 7 wherein a ganglioside is present and is selected from the group consisting of a mammalian brain ganglioside extract and human milk ganglioside extract, human colostrum ganglioside extract and ganglioside fraction GD1a.
Claim 11
Independent Claim
36 words
A method for reducing the number of gastrointestinal disease-producing organisms comprising substantially homogeneously admixing about 0.005 to about 0.1 percent of the total food weight of N-actylneuraminic acid or a ganglioside to a young mammal's food.
Claim 12
Independent Claim
36 words
A method for reducing the number of gastrointestinal disease-producing organisms comprising substantially homogeneously admixing about 0.005 to about 0.1 percent of the total food weight of N-actylneuraminic acid or a ganglioside to a young mammal's food.
Claim 13
Dependent Claim
35 words
The method according to claim 9 wherein a ganglioside is present and is selected from the group consisting of mammalian brain ganglioside extract, human milk ganglioside extract, human colostrum ganglioside extract and ganglioside fraction GD1a.
Claim 14
Dependent Claim
21 words
The method according to claim 9 wherein the number of gastrointestinal disease-producing organisms in said young mammal's gastrointestinal tract is reduced.
Claim 15
Independent Claim
52 words
A method for conferring antimicrobial activity on a mother's milk substitute in the form of animal feed or infant formula comprising substantially homogeneously admixing N-acetylneuraminic acid or a ganglioside to said mother's milk substitute in an amount of about 0.005 to about 0.1 percent of the total weight of the milk substitute.
Claim 16
Independent Claim
52 words
A method for conferring antimicrobial activity on a mother's milk substitute in the form of animal feed or infant formula comprising substantially homogeneously admixing N-acetylneuraminic acid or a ganglioside to said mother's milk substitute in an amount of about 0.005 to about 0.1 percent of the total weight of the milk substitute.
Claim 17
Dependent Claim
35 words
The method according to claim 12 wherein a ganglioside is present and is selected from the group consisting of mammalian brain ganglioside extract, human milk ganglioside extract, human colostrum ganglioside extract and ganglioside fraction GD1a.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-08-09 | 1992-02-08 | 1992-08-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-08-09 | 1996-02-08 | 1996-08-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-08-09 | 2000-02-08 | 2000-08-09 | $7700.00 | Window Closed / Lapsed |