US4758593A
Expired / Lapsed
US
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Method of feeding ketoisocaproate to lactating domestic mammals
Assignee: Iowa State University Research Foundation Inc
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Filing: 1986-03-11
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Granted: 1988-07-19
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Expires: 2006-03-11
Abstract
Abstract Lactating domestic mammals are fed ketoisocaproate (KIC) with a diet containing limited leucine to improve the quantity and quality of the milk produced. This feeding method is particularly applicable to dairy cattle but also can advantageously be used with nursing domestic animals including cattle, sheep, goats, horses, and swine.
Inventors
- 👤 Steven L. Nissen
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 00:28
CPC Classifications
A; A23; A23K; A23K50/00; A23K50/10; A23K20/00; A23K20/10; A23K20/105
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
90 words
The method of feeding lactating female domestic mammals to increase the quantity of milk produced and/or to increase the butterfat content of the milk, in which said lactating mammals are fed a protein-containing feed composition, wherein the improvement comprises orally administering to said lactating mammals from 2 to 1000 milligrams (mg) of alpha-ketoisocaproate (sodium KIC basis) per kilograms (Kg) of body weight per 24 hours (hrs) while limiting the dietary intake of leucine to not over 12% of the dry weight of the total protein being fed to the mammals.
Claim 2
Independent Claim
90 words
The method of feeding lactating female domestic mammals to increase the quantity of milk produced and/or to increase the butterfat content of the milk, in which said lactating mammals are fed a protein-containing feed composition, wherein the improvement comprises orally administering to said lactating mammals from 2 to 1000 milligrams (mg) of alpha-ketoisocaproate (sodium KIC basis) per kilograms (Kg) of body weight per 24 hours (hrs) while limiting the dietary intake of leucine to not over 12% of the dry weight of the total protein being fed to the mammals.
Claim 3
Dependent Claim
26 words
The method of claim 1 in which from 10 to 400 mg of KIC (sodium KIC basis) are administered per Kg body weight per 24 hrs.
Claim 4
Dependent Claim
29 words
The method of claim 1 in which said leucine intake is limited to less than 10% of the dry weight of the total protein being fed to the mammals.
Claim 5
Dependent Claim
19 words
The method of claim 1 in which said lactating mammals are dairy cattle being fed for commercial milk production.
Claim 6
Dependent Claim
20 words
The method of claim 1 in which said lactating mammals are being fed to produce milk for nursing young mammals.
Claim 7
Dependent Claim
22 words
The method of claim 1 in which said lactating mammals are selected from the group consisting of cattle, sheep, swine, and goats.
Claim 8
Independent Claim
100 words
The method of feeding lactating domestic mammals to increase the quantity of milk produced and/or increase the butterfat content of the milk, in which the mammals are fed an admixed feed composition containing at least 10% protein by weight on a dry matter basis, wherein the improvement comprises incorporating alpha-ketoisocaproate (KIC) in said feed composition prior to feeding to said mammals in the amount of from 0.01 to 2.0 weight percent (wt %) based on sodium KIC and the dry weight of the feed composition, said feed composition containing not over 12 wt % leucine based on the total protein.
Claim 9
Independent Claim
100 words
The method of feeding lactating domestic mammals to increase the quantity of milk produced and/or increase the butterfat content of the milk, in which the mammals are fed an admixed feed composition containing at least 10% protein by weight on a dry matter basis, wherein the improvement comprises incorporating alpha-ketoisocaproate (KIC) in said feed composition prior to feeding to said mammals in the amount of from 0.01 to 2.0 weight percent (wt %) based on sodium KIC and the dry weight of the feed composition, said feed composition containing not over 12 wt % leucine based on the total protein.
Claim 10
Dependent Claim
24 words
The method of claim 7 in which from 0.5 to 1.5 wt % of KIC (sodium KIC basis) is incorporated in said feed composition.
Claim 11
Dependent Claim
17 words
The method of claim 7 in which said KIC is in the form of its sodium salt.
Claim 12
Dependent Claim
17 words
The method of claim 7 in which said KIC is in the form of its calcium salt.
Claim 13
Independent Claim
109 words
The method of feeding lactating dairy cattle to increase the quantity of milk produced and/or increase the butterfat content of the milk, in which the cattle are fed an admixed feed composition containing from 12 to 22% protein by weight on a dry matter basis, wherein the improvement comprises incorporating alpha-ketoisocaproate (KIC) in said feed composition prior to feeding to said dairy cattle in an amount of from 0.01 to 2.0 weight percent (wt %) of KIC based on sodium KIC and the dry weight of the feed composition, said feed composition containing not over 10 wt % leucine based on the dry weight of the total protein therein.
Claim 14
Independent Claim
109 words
The method of feeding lactating dairy cattle to increase the quantity of milk produced and/or increase the butterfat content of the milk, in which the cattle are fed an admixed feed composition containing from 12 to 22% protein by weight on a dry matter basis, wherein the improvement comprises incorporating alpha-ketoisocaproate (KIC) in said feed composition prior to feeding to said dairy cattle in an amount of from 0.01 to 2.0 weight percent (wt %) of KIC based on sodium KIC and the dry weight of the feed composition, said feed composition containing not over 10 wt % leucine based on the dry weight of the total protein therein.
Claim 15
Dependent Claim
52 words
The method of claim 11 in which the admixed feed composition fed to said lactating dairy cattle contains from 0.5 to 1.5 wt % KIC based on sodium KIC and the dry weight of the feed composition, and said KIC is selected from the group consisting of sodium KIC and calcium KIC.
Claim 16
Dependent Claim
39 words
The method of claim 1 in which said KIC is orally administered without rumen protection thereof, the amount administered being effective to increase the quantity of milk produced, and/or being effective to increase the butterfat content of the milk.
Claim 17
Dependent Claim
40 words
The method of claim 1 in which said KIC is orally administered in a rumen-protected form, the amount so administered being effective to increase the quantity of milk produced, and/or being effective to increase the butterfat content of the milk.
Claim 18
Dependent Claim
45 words
The method of claim 7 in which said KIC is incorporated in said feed composition without rumen protection thereof, the amount of KIC so incorporated being effective to increase the quantity of milk produced, and/or being effective to increase the butterfat content of the milk.
Claim 19
Dependent Claim
46 words
The method of claim 7 in which said KIC is incorporated in said feed composition in a rumen protected form, the amount of KIC so incorporated being effective to increase the quantity of milk produced, and/or being effective to increase the butterfat content of the milk.
Claim 20
Dependent Claim
45 words
The method of claim 11 in which said KIC is incorporated in said feed composition without rumen protection thereof, the amount of KIC so incorporated being effective to increase the quantity of milk produced, and/or being effective to increase the butterfat content of the milk.
Claim 21
Dependent Claim
45 words
The method of claim 11 in which said KIC is incorporated in said feed composition in a rumen-protected form, the amount of KIC so incorporated being effective to increase the quantity of milk produced, and/or being effective to increase the butterfat content of the milk.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-07-19 | 1992-01-18 | 1992-07-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-07-19 | 1996-01-18 | 1996-07-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-07-19 | 2000-01-18 | 2000-07-19 | $7700.00 | Window Closed / Lapsed |