US4757059A
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Method for treating convulsions and epilepsy with organic copper compounds
Assignee: International Copper Research Assn Inc
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Filing: 1986-12-08
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Granted: 1988-07-12
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Expires: 2006-12-08
Abstract
Abstract Copper-dependent enzymes are required for normal brain development and function. Copper deficiency can result in pathological disorders accompanied by convulsive seizures or tremors in man and animals. The present invention is directed to a method for treating convulsions or epilepsy comprising administration of a therapeutically effective amount of an organic compound of copper having anticonvulsant activity. These compounds include copper complexes of carboxylic acids, acylsalicylates, salicylates, amino acids, imines and known anticonvulsant and antiepileptic drugs.
Inventors
- 👤 John R. J. Sorenson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 13:59
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/28; A61K31/30
Claims Analysis
Total Claims: 24
Claim 1
Independent Claim
50 words
A method of treating convulsive tremors or convulsive seizures comprising administration to a mammal of a therapeutically effective amount of an organic compound of copper having anticonvulsant activity selected from the group consisting of a copper complex of an amino acid and a mixture of copper complexes of amino acids.
Claim 2
Independent Claim
50 words
A method of treating convulsive tremors or convulsive seizures comprising administration to a mammal of a therapeutically effective amount of an organic compound of copper having anticonvulsant activity selected from the group consisting of a copper complex of an amino acid and a mixture of copper complexes of amino acids.
Claim 3
Independent Claim
46 words
A method of treating epilepsy comprising administration to a mammal of a therapeutically effective amount of an organic compound of copper having antiepileptic activity selected from the group consisting of a copper complex of an amino acid and a mixture of copper complexes or amino acids.
Claim 4
Independent Claim
46 words
A method of treating epilepsy comprising administration to a mammal of a therapeutically effective amount of an organic compound of copper having antiepileptic activity selected from the group consisting of a copper complex of an amino acid and a mixture of copper complexes or amino acids.
Claim 5
Dependent Claim
72 words
The method according to claim 1 or 2 wherein the organic compound of copper is selected from the group consisting of: (a) Cu(II)(L-threoninate)(L-serinate); (b) Cu(II)(L-threoninate)(L-alaninate); (c) Cu(II)(L-valinate) 2 H 2 O; (d) Cu(II)(L-threoninate) 2 H 2 O; (e) Cu(II)(L-alaninate) 2 ; (f) Cu(II)(L-phenylalaninate) 2 ; (g) Cu(II)(L-cystinate) 2 H 2 O; (h) Cu(II)(L-isoleucinate) 2 ; (i) Cu(II)(L-glutamate) 2 ; (j) Cu(II)(L-tryptophanate) 2 ; (k) Cu(II)(L-serinate) 2 ; and (l) Cu(II)(L-leucinate) 2 .
Claim 6
Independent Claim
48 words
A method of treating convulsive tremors or convulsive seizures comprising administration to a mammal of a therapeutically effective amount of an organic compound of copper having anticonvulsant activity selected from the group consisting of a copper complex of an imine and a mixture of copper complexes of imines.
Claim 7
Independent Claim
48 words
A method of treating convulsive tremors or convulsive seizures comprising administration to a mammal of a therapeutically effective amount of an organic compound of copper having anticonvulsant activity selected from the group consisting of a copper complex of an imine and a mixture of copper complexes of imines.
Claim 8
Independent Claim
44 words
A method of treating epilepsy comprising administration to a mammal of a therapeutically effective amount of an organic compound of copper having antiepileptic activity selected from the group consisting of a copper complex of an imine and a mixture of copper complexes of imines.
Claim 9
Independent Claim
44 words
A method of treating epilepsy comprising administration to a mammal of a therapeutically effective amount of an organic compound of copper having antiepileptic activity selected from the group consisting of a copper complex of an imine and a mixture of copper complexes of imines.
Claim 10
Dependent Claim
16 words
The method according to claim 4 or 5 wherein the imine is a bisethyleneimine Schiff base.
Claim 11
Dependent Claim
23 words
The method according to claim 6 wherein the bisethyleneimine Schiff base is selected from the group consisting of: (a) Cu(II)bisacetylacetonethyleneimine; and (b) Cu(II)bissalicylatoethyleneimine.
Claim 12
Dependent Claim
17 words
The method according to claim 4 or 5 wherein the imine is a salicylidene-amino acid Schiff base.
Claim 13
Dependent Claim
24 words
The method according to claim 8 wherein the salicylidene-amino acid Schiff base is selected from the group consisting of: (a) Cu(II)salicylidene-L-valinate; and (b) Cu(II)salicylidene-L-histidinate.
Claim 14
Dependent Claim
17 words
The method according to claim 4 or 5 wherein the imine is a pyridoxylidene-amino acid Schiff base.
Claim 15
Dependent Claim
43 words
The method according to claim 10 wherein the pyridoxylidene-amino acid Schiff base is selected from the group consisting of: (a) Cu(II)pyridoxylideneglycinate(H 2 O) 1 .5 ; (b) Cu(II)pyridoxylidene-L-serinate(H 2 O); (c) Cu(II)pyridoxylidene-L-tryptophanate(H 2 O) 2 ; and (d) Cu(II)pyridoxylidene-L-threoninate(H 2 O) 2 .
Claim 16
Dependent Claim
18 words
The method according to claim 1, 2, 4 or 5 wherein the organic copper compound is administered intravenously.
Claim 17
Dependent Claim
18 words
The method according to claim 1, 2, 4 or 5 wherein the organic copper compounds is administered intraperitoneally.
Claim 18
Dependent Claim
18 words
The method according to claim 1, 2, 4 or 5 wherein the organic copper compound is administered subcutaneously.
Claim 19
Dependent Claim
18 words
The method according to claim 1, 2, 4 or 5 wherein the organic copper compound is administered orally.
Claim 20
Dependent Claim
18 words
The method according to claim 1, 2, 4 or 5 wherein the organic copper compound is administered topically.
Claim 21
Dependent Claim
32 words
The method according to claim 1, 2, 4 or 5 wherein the organic copper compound is administered in an amount between about 0.1 to about 100 milligrams per kilogram of body weight.
Claim 22
Dependent Claim
28 words
The method according to claim 1 wherein the organic copper compound is administered in an amount between about 0.1 to about 600 milligrams per kilogram of body weight.
Claim 23
Dependent Claim
26 words
The method according to claim 1, 2, 4 or 5 wherein the organic copper compound is administered in the form of a solution, suspension or ointment.
Claim 24
Dependent Claim
23 words
The method according to claim 19 wherein the solution, suspension or ointment includes saline, ethylene glycol or a suspending agent like polyoxyethylene glycol.
References Cited (Backward Citations)
No citation records indexed.
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