US4755612A
Expired / Lapsed
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Intermediate compounds resulting from method for forming a dihydrogen-phosphate inositol
Assignee: Merck and Co Inc
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Filing: 1987-07-20
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Granted: 1988-07-05
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Expires: 2007-07-20
Abstract
Abstract This invention relates to novel intermediate compounds resulting from a method for forming a dihydrogen-phosphate inositol from a protected or unprotected inositol that comprises at least two vicinal trans hydroxy groups that are unprotected. This method results in each of the unprotected hydroxy groups of the inositol, which can contain from two to six unprotected hydroxy groups, being converted to a dihydrogen-phosphate group and each protected group being converted to a free hydroxy group. The method permits one to make such compounds in very few steps and in very high yields.
Inventors
- 👤 Joseph P. Vacca
- 👤 S. Jane deSolms
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 17:03
CPC Classifications
C; C07; C07F; C07F9/00; C07F9/02; C07F9/547; C07F9/655; C07F9/65515; C07F9/65517; C07F9/06; C07F9/08; C07F9/09; C07F9/117
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
165 words
A compound having the general structure IV: ##STR41## wherein Y is (Z 1 --O) 2 ; each Z 1 is independently selected from the group consisting of: ##STR42## each Z 2 is independently selected from the group consisting of C 1-4 alkyl and ##STR43## each R 1 is independently selected from the group consisting of H, C 1-4 alkyl and ##STR44## each X is independently selected from the group consisting of H, halogen, C 1-4 alkyl, C 1-4 alkoxy, C 1-4 alkylthio, carboxyl, carboxyl C 1-4 alkyl, nitro, --CF 3 , and hydroxy; R 1 3 and R 2 3 are each independently selected from the group consisting of Z 1 and ##STR45## each Z 3 is independently selected from the group consisting of H, C 1-4 alkyl, and ##STR46## or each Z 3 is an alkyl joined to form a 5 or 6 membered cycloalkyl group; and each R 5 is independently selected from the group consisting of H, 3 H, and 2 H.
Claim 2
Dependent Claim
165 words
A compound having the general structure IV: ##STR41## wherein Y is (Z 1 --O) 2 ; each Z 1 is independently selected from the group consisting of: ##STR42## each Z 2 is independently selected from the group consisting of C 1-4 alkyl and ##STR43## each R 1 is independently selected from the group consisting of H, C 1-4 alkyl and ##STR44## each X is independently selected from the group consisting of H, halogen, C 1-4 alkyl, C 1-4 alkoxy, C 1-4 alkylthio, carboxyl, carboxyl C 1-4 alkyl, nitro, --CF 3 , and hydroxy; R 1 3 and R 2 3 are each independently selected from the group consisting of Z 1 and ##STR45## each Z 3 is independently selected from the group consisting of H, C 1-4 alkyl, and ##STR46## or each Z 3 is an alkyl joined to form a 5 or 6 membered cycloalkyl group; and each R 5 is independently selected from the group consisting of H, 3 H, and 2 H.
Claim 3
Dependent Claim
12 words
A compound in accordance with claim 1 having the general structure: ##STR47##
Claim 4
Dependent Claim
14 words
A compound in accordance with claim 2 selected from the group consisting of: ##STR48##
Claim 5
Dependent Claim
11 words
A compound in accordance with claim 3 wherein Y is ##STR49##
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-07-05 | 1992-01-04 | 1992-07-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-07-05 | 1996-01-04 | 1996-07-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-07-05 | 2000-01-04 | 2000-07-05 | $7700.00 | Window Closed / Lapsed |