US4755518A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Imidazolyl or tetrazolyl substituted benzoic acid derivatives and pharmaceutical compositions thereof
Assignee: Warner Lambert Co LLC
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Filing: 1986-11-10
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Granted: 1988-07-05
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Expires: 2006-11-10
Abstract
Abstract Novel benzoic acid or benzoic acid ester derivatives, pharmaceutical compositions and methods of use thereof are the present invention. Utility is for the treatment of arthritis, asthma, Raynaud's disease, inflammatory bowel disorders, trigeminal or herpetic neuralgia, inflammatory eye disorders, psoriasis, dental pain, and headaches, particularly vascular headaches, such as migraine, cluster, mixed vascular syndromes, as well as nonvascular, tension headaches.
Inventors
- 👤 Michael F. Rafferty
- 👤 Graham Johnson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 22:00
CPC Classifications
C; C07; C07D; C07D257/00; C07D257/02; C07D257/04
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
124 words
A compound of the formula: ##STR9## wherein: (a) R 1 is tetrazolyl or COOR' wherein R' is H or lower alkyl of one to four carbons, inclusive; (b) B is ##STR10## (c) X and Y are independently H or lower alkyl of one to four carbons, inclusive; (d) R 2 is alkylene, alkenylene, alkynylene branched or linear chains of 1 to 11 carbons, inclusive; (e) Q is CH 3 , COOH, Br, NH 2 , H, imidazolyl, cyclohexyl, ##STR11## with the proviso that when B is (B 1 ) and Q is H, R 2 is not methylene and further with the proviso that when R 1 is COOR' then Q consists of imidazolyl; or nontoxic, pharmaceutically acceptable acid addition or base salt thereof.
Claim 2
Dependent Claim
124 words
A compound of the formula: ##STR9## wherein: (a) R 1 is tetrazolyl or COOR' wherein R' is H or lower alkyl of one to four carbons, inclusive; (b) B is ##STR10## (c) X and Y are independently H or lower alkyl of one to four carbons, inclusive; (d) R 2 is alkylene, alkenylene, alkynylene branched or linear chains of 1 to 11 carbons, inclusive; (e) Q is CH 3 , COOH, Br, NH 2 , H, imidazolyl, cyclohexyl, ##STR11## with the proviso that when B is (B 1 ) and Q is H, R 2 is not methylene and further with the proviso that when R 1 is COOR' then Q consists of imidazolyl; or nontoxic, pharmaceutically acceptable acid addition or base salt thereof.
Claim 3
Dependent Claim
10 words
A compound of claim 1 wherein R 1 is tetrazolyl.
Claim 4
Dependent Claim
8 words
A compound of claim 2 and being N-[[4-(1H-tetrazol-5-yl)phenyl]methyl]nonanamide.
Claim 5
Dependent Claim
115 words
A pharmaceutical composition comprising an effective amount of a compound of the formula: ##STR12## Wherein: (a) R 1 is tetrazolyl or COOR' wherein R' is H or lower alkyl of one to four carbons, inclusive; (b) B is ##STR13## (c) X and Y are independently H or lower alkyl of one to four carbons, inclusive; (d) R 2 is alkylene, alkenylene, alkynylene branched or linear chains of 1 to 11 carbons, inclusive; (e) Q is CH 3 , COOH, Br, NH 2 , H, imidazolyl, cyclohexyl, ##STR14## with the proviso that when R 1 is COOR' then Q is imidazolyl or nontoxic, pharmaceutically acceptable acid addition or base salt thereof; and a pharmaceutically acceptable carrier.
Claim 6
Dependent Claim
115 words
A pharmaceutical composition comprising an effective amount of a compound of the formula: ##STR12## Wherein: (a) R 1 is tetrazolyl or COOR' wherein R' is H or lower alkyl of one to four carbons, inclusive; (b) B is ##STR13## (c) X and Y are independently H or lower alkyl of one to four carbons, inclusive; (d) R 2 is alkylene, alkenylene, alkynylene branched or linear chains of 1 to 11 carbons, inclusive; (e) Q is CH 3 , COOH, Br, NH 2 , H, imidazolyl, cyclohexyl, ##STR14## with the proviso that when R 1 is COOR' then Q is imidazolyl or nontoxic, pharmaceutically acceptable acid addition or base salt thereof; and a pharmaceutically acceptable carrier.
References Cited (Backward Citations)
US3514383A
Cited
US3953499A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-07-05 | 1992-01-04 | 1992-07-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-07-05 | 1996-01-04 | 1996-07-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-07-05 | 2000-01-04 | 2000-07-05 | $7700.00 | Window Closed / Lapsed |