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US4755378A
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Iodophor-containing suppository
Assignee: Euro Celtique SA
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Filing: 1986-07-30
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Granted: 1988-07-05
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Expires: 2006-07-30
Abstract
Abstract Iodophor-containing suppositories are provided with improved rate of iodine release from the suppository. The suppository composition comprises an iodophor, a water soluble suppository base, at least one water soluble sugar having a molecular weight of between about 90 and 550, and water in an amount of at least about 30% by weight. The molecular weight of the sugar is preferably between about 150 and 370. The preferred iodophors are providone iodine and polydextrose iodine. The preferred suppository bases are gelling polysaccharides and the preferred sugars are monosaccharides, disaccharides and sugar alcohols. The rate of iodine release is improved because of the high concentration of water together with the presence of the low molecular weight sugar.
Inventors
- 👤 Ian R. Buxton
- 👤 Stewart T. Leslie
- 👤 Sandra T. A. Malkowska
- 👤 Joanne Marchant
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 14:28
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/02; A61K33/00; A61K33/18; A61K47/00; A61K47/06; A61K47/26; A61K47/50; A61K47/51; A61K47/56; A61K47/58; A61K47/61
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
77 words
A suppository formed of at least one iodophor in an amount and with sufficient iodine concentration to provide germicidal activity, a water-soluble suppository base and at least one water-soluble sugar or sugar alcohol having a molecular weight between about 90 and 550 in amounts sufficient to provide rigidity to the suppository, and water in an amount of at least about 30% by weight, wherein the water and sugar or sugar alcohol increases the level of iodine activity.
Claim 2
Dependent Claim
77 words
A suppository formed of at least one iodophor in an amount and with sufficient iodine concentration to provide germicidal activity, a water-soluble suppository base and at least one water-soluble sugar or sugar alcohol having a molecular weight between about 90 and 550 in amounts sufficient to provide rigidity to the suppository, and water in an amount of at least about 30% by weight, wherein the water and sugar or sugar alcohol increases the level of iodine activity.
Claim 3
Dependent Claim
18 words
Suppository according to claim 1 wherein the amount of water is between about 40 and 80% by weight.
Claim 4
Dependent Claim
18 words
Suppository according to claim 1 wherein the amount of water is between about 50 and 70% by weight.
Claim 5
Dependent Claim
14 words
Suppository according to claim 1 wherein the iodophor is povidone iodine or polydextrose iodine.
Claim 6
Dependent Claim
15 words
Suppository according to claim 1 wherein the suppository base is a water soluble, gelling polysaccharide.
Claim 7
Dependent Claim
19 words
Suppository according to claim 1 wherein the suppository base is agar, an alginate salt, a cellulose derivative or carrageenan.
Claim 8
Dependent Claim
18 words
Suppository according to claim 1 wherein the molecular weight of the sugar is between about 150 and 370.
Claim 9
Dependent Claim
14 words
Suppository according to claim 1 wherein the sugar is a monosaccharide or a disaccharide.
Claim 10
Dependent Claim
24 words
Suppository according to claim 1 wherein the water soluble sugar or sugar alcohol is glucose, fructose, galactose, mannose, sucrose, lactose, mannitol, sorbitol or xylitol.
Claim 11
Dependent Claim
21 words
Suppository according to claim 1 wherein the concentration of sugar or sugar alcohol is between about 5 and 50% by weight.
Claim 12
Dependent Claim
21 words
Suppository according to claim 1 wherein the concentration of sugar or sugar alcohol is between about 10 and 35% by weight.
Claim 13
Dependent Claim
12 words
Suppository according to claim 1 and also including a water soluble polyalcohol.
Claim 14
Dependent Claim
12 words
Suppository according to claim 1 in the form of a vaginal suppository.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-07-05 | 1992-01-04 | 1992-07-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-07-05 | 1996-01-04 | 1996-07-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-07-05 | 2000-01-04 | 2000-07-05 | $7700.00 | Window Closed / Lapsed |