US4753797A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Enhancing platelet morphology prior to patient use
Assignee: Bayer Corp
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Filing: 1987-06-24
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Granted: 1988-06-28
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Expires: 2007-06-24
Abstract
Abstract Platelet morphology in platelet concentrates is significantly enhanced by subjecting the platelets to a gentle heating step. Platelets heated at 37 DEG C. for one hour have at least a 25% increase in the number of disc-like forms over non-heated platelets. When subsequently infused in a patient, the treated platelets show a one hour post-infusion platelet corrected count increment of about 70% higher than non-heated control platelets.
Inventors
- 👤 Randy B. Garcez
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 09:50
CPC Classifications
A; A61; A61K; A61K35/00; A61K35/12; A61K35/14; A61K35/19
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
58 words
A method of treeating platelets in a platelet concentrate preparation, the method comprising incubating the preparation prior to infusion into a patient at elevated temperatures for a period of time sufficient to result in an increase of at least 25% in the number of discoid platelets when compared with non-incubated platelets at a given time of platelet storage.
Claim 2
Independent Claim
58 words
A method of treeating platelets in a platelet concentrate preparation, the method comprising incubating the preparation prior to infusion into a patient at elevated temperatures for a period of time sufficient to result in an increase of at least 25% in the number of discoid platelets when compared with non-incubated platelets at a given time of platelet storage.
Claim 3
Dependent Claim
13 words
The method of claim 1 wherein the increase is at least about 50%.
Claim 4
Dependent Claim
17 words
The method of claim 1 wherein the incubation is at a temperature of about 37 ° C.
Claim 5
Dependent Claim
15 words
The method of claim 1 wherein the incubation is for at least about 40 minutes.
Claim 6
Dependent Claim
18 words
The method of claim 1 wherein the incubation is at 37 ° C. for least about one hour.
Claim 7
Dependent Claim
95 words
In a method of preparing a platelet concentrate suitable for infusion into a patient and comprising the steps of (a) collecting whole blood from a donor and separating the blood into a red blood cell component and a platelet rich plasma component; (b) separating platelets from the platelet rich plasma component; the improvement comprising incubating the separated platelets at about 37 ° C. for at least about 40 minutes under conditions sufficient to increase the number of discoid platelets by at least 25% when compared with non-incubated platelets at a given time in platelet storage.
Claim 8
Dependent Claim
95 words
In a method of preparing a platelet concentrate suitable for infusion into a patient and comprising the steps of (a) collecting whole blood from a donor and separating the blood into a red blood cell component and a platelet rich plasma component; (b) separating platelets from the platelet rich plasma component; the improvement comprising incubating the separated platelets at about 37 ° C. for at least about 40 minutes under conditions sufficient to increase the number of discoid platelets by at least 25% when compared with non-incubated platelets at a given time in platelet storage.
Claim 9
Dependent Claim
12 words
The method of claim 6 wherein the increase is at least 50%.
Claim 10
Dependent Claim
22 words
The method of claim 6 wherein prior to the incubation step, substantially all residual WBCs and RBCs are removed from the platelets.
Claim 11
Dependent Claim
20 words
A platelet concentrate comprising at least about 65% platelets having a disc-like shape after 7 days storage at room temperature.
Claim 12
Dependent Claim
20 words
A platelet concentrate comprising at least about 65% platelets having a disc-like shape after 7 days storage at room temperature.
Claim 13
Dependent Claim
11 words
The platelet concentrate of claim 9 in a platelet pooling bag.
Claim 14
Dependent Claim
11 words
The platelet concentrate of claim 9 in a gas-transmissible plastic bag.
Claim 15
Dependent Claim
21 words
The platelet concentrate of claim 9 wherein the bag is made from a plastic film comprising polyvinylchloride plasticized with trioctyltrimellitate plasticizer.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-06-28 | 1991-12-28 | 1992-06-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-06-28 | 1995-12-28 | 1996-06-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-06-28 | 1999-12-28 | 2000-06-28 | $7700.00 | Window Closed / Lapsed |