US4751095A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Aspartame stabilization with cyclodextrin
Assignee: Henkel Corp
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Filing: 1985-04-09
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Granted: 1988-06-14
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Expires: 2005-04-09
Abstract
Abstract The present invention deals with the stabilization of aspartame, by the formation of an inclusion complex of aspartame and cyclodextrin. The inclusion complex is formed by combining the aspartame with the cyclodextrin in a medium suitable for formation of the inclusion complex before a substantial degree of hydrolysis of the aspartame can occur. Upon drying a dry inclusion complex is formed.
Inventors
- 👤 Curtis L. Karl
- 👤 Wolfram G. Schynoll
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 11:38
CPC Classifications
A; A21; A21D; A21D2/00; A21D2/08; A21D2/24; A23; A23G; A23G3/00; A23G3/34; A23G3/346; A23L; A23L27/00; A23L27/30; A23L27/31; A23L27/32; A23G2200/00; A23G2200/06
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
67 words
A method of stabilizing aspartame from hydrolysis comprising combining aspartame and a larger amount of a member selected from the group consisting of: (a) alpha-cyclodextrin; (b) beta-cyclodextrin; and (c) gamma-cyclodextrin; in a medium suitable for the formation of an inclusion complex between the cyclodextrin and the aspartame, wherein the aspartame and the cyclodextrin form an inclusion complex before a substantial degree of hydrolysis of the aspartame occurs.
Claim 2
Independent Claim
67 words
A method of stabilizing aspartame from hydrolysis comprising combining aspartame and a larger amount of a member selected from the group consisting of: (a) alpha-cyclodextrin; (b) beta-cyclodextrin; and (c) gamma-cyclodextrin; in a medium suitable for the formation of an inclusion complex between the cyclodextrin and the aspartame, wherein the aspartame and the cyclodextrin form an inclusion complex before a substantial degree of hydrolysis of the aspartame occurs.
Claim 3
Dependent Claim
20 words
A method as described in claim 1 wherein the ratio by weight of cyclodextrin to aspartame is at least 1.1:1.
Claim 4
Independent Claim
82 words
A method for the formation of a dry inclusion complex so that aspartame is stabilized from hydrolysis comprising: (1) combining aspartame and a larger amount of a member selected from the group consisting of: (a) alpha-cyclodextrin (b) beta-cyclodextrin and (c) gamma-cyclodextrin in a suitable medium to form a mixture containing an inclusion complex of said aspartame and said cyclodextrin, before a substantial degree of hydrolysis of said aspartame can occur and (2) drying said mixture whereby said dry inclusion complex is formed.
Claim 5
Independent Claim
82 words
A method for the formation of a dry inclusion complex so that aspartame is stabilized from hydrolysis comprising: (1) combining aspartame and a larger amount of a member selected from the group consisting of: (a) alpha-cyclodextrin (b) beta-cyclodextrin and (c) gamma-cyclodextrin in a suitable medium to form a mixture containing an inclusion complex of said aspartame and said cyclodextrin, before a substantial degree of hydrolysis of said aspartame can occur and (2) drying said mixture whereby said dry inclusion complex is formed.
Claim 6
Dependent Claim
17 words
A method as described in claim 3 wherein said drying is either spray drying or freeze drying.
Claim 7
Dependent Claim
12 words
A method as described in claim 3 wherein the cyclodextrin is beta-cyclodextrin.
Claim 8
Dependent Claim
20 words
A method as defined in claim 3 wherein the ratio by weight of cyclodextrin to aspartame is at least 1.1:1.
Claim 9
Dependent Claim
22 words
A method as defined in claim 3 wherein the ratio by weight of cyclodextrin to aspartame is from about 1.1:1 to 100:1.
Claim 10
Dependent Claim
95 words
A composition comprising a dry inclusion complex formed between aspartame and a member selected from the group consisting of: (a) alpha-cyclodextrin; (b) beta-cyclodextrin; and (c) gamma-cyclodextrin, wherein said dry inclusion complex is prepared from the process comprising: (1) combining aspartame and a larger amount of the cyclodextrin in a medium suitable for the formation of an inclusion complex before a substantial degree of hydrolysis of the aspartame occurs, to form a mixture containing an inclusion complex of said aspartame and said cyclodextrin, and then (2) drying said mixture whereby said dry inclusion complex is formed.
Claim 11
Dependent Claim
95 words
A composition comprising a dry inclusion complex formed between aspartame and a member selected from the group consisting of: (a) alpha-cyclodextrin; (b) beta-cyclodextrin; and (c) gamma-cyclodextrin, wherein said dry inclusion complex is prepared from the process comprising: (1) combining aspartame and a larger amount of the cyclodextrin in a medium suitable for the formation of an inclusion complex before a substantial degree of hydrolysis of the aspartame occurs, to form a mixture containing an inclusion complex of said aspartame and said cyclodextrin, and then (2) drying said mixture whereby said dry inclusion complex is formed.
Claim 12
Dependent Claim
22 words
A composition as described in claim 8 wherein: the medium is selected from the group consisting of water; aqueous methanol; and ethanol.
Claim 13
Dependent Claim
12 words
A composition as described in claim 8 wherein the cyclodextrin is beta-cyclodextrin.
Claim 14
Dependent Claim
20 words
A composition as defined in claim 8 wherein the ratio by weight of cyclodextrin to aspartame is at least 1.1:1.
Claim 15
Dependent Claim
23 words
A composition as defined in claim 8 wherein the ratio by weight of cyclodextrin to aspartame is from about 1.1:1 to about 100:1.
References Cited (Backward Citations)
JPS5642560A
Cited
US4332825A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-06-14 | 1991-12-14 | 1992-06-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-06-14 | 1995-12-14 | 1996-06-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-06-14 | 1999-12-14 | 2000-06-14 | $7700.00 | Window Closed / Lapsed |