US4749511A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Contact lens cleaning solutions containing endoproteinase lys-C
Assignee: Genencor Inc
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Filing: 1986-07-31
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Granted: 1988-06-07
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Expires: 2006-07-31
Abstract
Abstract Contact lens cleaning compositions and a method which comprises treating soft contact lenses with general purpose proteases in combination with endoproteinase lys-C are effective in dissolving away and hydrolyzing lysozyme, the major protein component of tears.
Inventors
- 👤 Pushkaraj J. Lad
- 👤 Leslie R. Woodhouse
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 00:20
CPC Classifications
C; C11; C11D; C11D3/00; C11D3/16; C11D3/38; C11D3/386; C11D3/38618; C11D3/0005; C11D3/0078
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
52 words
A method to clean contact lenses, which method comprises treating said lenses with from 0.1 to 20 μg/ml of a protease selected from the group consisting of: papain, pancreatin, trypsin, chymotrypsin, pepsin, streptokinase, streptodornase, ficin, carboxypeptidase, aminopeptidase, chymopapain, bromelin and subtilisin and with from 0.1 to 20 μg/ml of an endoproteinase lys-C.
Claim 2
Independent Claim
52 words
A method to clean contact lenses, which method comprises treating said lenses with from 0.1 to 20 μg/ml of a protease selected from the group consisting of: papain, pancreatin, trypsin, chymotrypsin, pepsin, streptokinase, streptodornase, ficin, carboxypeptidase, aminopeptidase, chymopapain, bromelin and subtilisin and with from 0.1 to 20 μg/ml of an endoproteinase lys-C.
Claim 3
Dependent Claim
10 words
The method of claim 1 wherein the protease is subtilisin.
Claim 4
Dependent Claim
10 words
The method of claim 1 wherein the protease is papain.
Claim 5
Dependent Claim
14 words
The method of claim 1 wherein the endoproteinase lys-C is derived from Lysobacter enzymogenes.
Claim 6
Dependent Claim
12 words
The method of claim 2 wherein the subtilisin is resistant to oxidation.
Claim 7
Dependent Claim
16 words
The method of claim 1 wherein the treatment with endoproteinase lys-C and with protease is simultaneous.
Claim 8
Dependent Claim
18 words
The method of claim 1 wherein the lens is pretreated with endoproteinase lys-C and subsequently treated with protease.
Claim 9
Dependent Claim
17 words
The method of claim 1 wherein which further includes treating the lens with a disulfide cleavage reagent.
Claim 10
Dependent Claim
54 words
A composition for cleaning soft contact lenses which comprises (1) a protease selected from the group consisting of: papain, pancreatin, trypsin, chymotrypsin, pepsin, streptokinase, streptodornase, ficin, carboxypeptidase, aminopeptidase, chymopapain, bromelin and subtilisin in a concentration of from 0.1 to 20 μg/ml; and (2) endoproteinase lys-C in a concentration of from 0.1 to 20 μg/ml.
Claim 11
Dependent Claim
54 words
A composition for cleaning soft contact lenses which comprises (1) a protease selected from the group consisting of: papain, pancreatin, trypsin, chymotrypsin, pepsin, streptokinase, streptodornase, ficin, carboxypeptidase, aminopeptidase, chymopapain, bromelin and subtilisin in a concentration of from 0.1 to 20 μg/ml; and (2) endoproteinase lys-C in a concentration of from 0.1 to 20 μg/ml.
Claim 12
Dependent Claim
10 words
The composition of claim 9 wherein the protease is subtilisin.
References Cited (Backward Citations)
US4414332A
Cited
US4511490A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-06-07 | 1991-12-07 | 1992-06-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-06-07 | 1995-12-07 | 1996-06-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-06-07 | 1999-12-07 | 2000-06-07 | $7700.00 | Window Closed / Lapsed |