US4748181A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method for treating hypertension with nicotine
Assignee: Foundation for Behavioral Resources
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Filing: 1985-05-15
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Granted: 1988-05-31
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Expires: 2005-05-15
Abstract
Abstract Hypertension is treated by chronic administration of nicotine or pharmaceutically acceptable salt of nicotine. More specifically, essential hypertension is treated in primates using effective dosages of nicotine.
Inventors
- 👤 Ronald R. Hutchinson
- 👤 Grace S. Emley
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 00:14
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/435; A61K31/465
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
62 words
A method of treating essential hypertension which comprises administering to a hypertensive primate subject afflicted with essential hypertension and requiring such treatment, over a period of at least several weeks, a therapeutically effective amount, for chronic treatment to obtain an antihypertensive effect, of nicotine or pharmacologically acceptable acid addition salt of nicotine, in combination with a pharmacologically acceptable carrier, diluent or vehicle.
Claim 2
Independent Claim
62 words
A method of treating essential hypertension which comprises administering to a hypertensive primate subject afflicted with essential hypertension and requiring such treatment, over a period of at least several weeks, a therapeutically effective amount, for chronic treatment to obtain an antihypertensive effect, of nicotine or pharmacologically acceptable acid addition salt of nicotine, in combination with a pharmacologically acceptable carrier, diluent or vehicle.
Claim 3
Dependent Claim
34 words
A method according to claim 1 in which said therapeutically effective amount is in the range of about 0.00007 to 0.02 mg per kg of body weight, per hour, calculated as nicotine per hour.
Claim 4
Dependent Claim
26 words
A method according to claim 1, in which said salt is selected from the group consisting of nicotine tartrate, nicotine bitartrate, nicotine hydrochloride and nicotine sulfate.
Claim 5
Dependent Claim
16 words
A method according to claim 1 or claim 2, in which the administration is oral administration.
Claim 6
Dependent Claim
34 words
A method according to claim 1, in which said therapeutically effective amount is in the range of from about 0.000.1 to about 1.0 mg per kg of body weight, per hour, calculated as nicotine.
References Cited (Backward Citations)
US3870794A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-05-31 | 1991-11-30 | 1992-05-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-05-31 | 1995-11-30 | 1996-05-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-05-31 | 1999-11-30 | 2000-05-31 | $7700.00 | Window Closed / Lapsed |