Anti-inflammatory products derived from methylene-diphosphonic acid, and process for their preparation

Claim 1

A method for treating inflamation which comprises administering to an animal in need of such treatment an anti-inflammatory effective amount of a methylene-diphosphonic acid compound having the formula ##STR56## in which: R 1 is hydrogen or a straight or branched lower alkyl group having from 1 to 4 carbon atoms, R 2 is: hydrogen, an alkyl group having from 1 to 16 carbon atoms which is unsubstituted or substituted by a phenyl group, a hydroxyl group, a thiol group, one or more halogen atoms, ##STR57## where Z 1 and Z 2 , considered independently of one another, are hydrogen or a lower alkyl group, a phenyl group which is unsubstituted or substituted one or more times by halogen, a nitro group, a lower alkyl group, a lower alkoxy group, trifluoromethyl, an NH 2 group, or a COOH group, or ##STR58## where X is oxygen or sulfur and Z 1 and Z 2 are as defined above, R 3 is hydrogen or a hydroxyl group, and n is an integer between 0 and 10, except that n cannot be 0 if R 3 is OH, or a salt of such compound with an organic or inorganic bases when R 1 =H.

Claim 2

A method for treating inflamation which comprises administering to an animal in need of such treatment an anti-inflammatory effective amount of a methylene-diphosphonic acid compound having the formula ##STR56## in which: R 1 is hydrogen or a straight or branched lower alkyl group having from 1 to 4 carbon atoms, R 2 is: hydrogen, an alkyl group having from 1 to 16 carbon atoms which is unsubstituted or substituted by a phenyl group, a hydroxyl group, a thiol group, one or more halogen atoms, ##STR57## where Z 1 and Z 2 , considered independently of one another, are hydrogen or a lower alkyl group, a phenyl group which is unsubstituted or substituted one or more times by halogen, a nitro group, a lower alkyl group, a lower alkoxy group, trifluoromethyl, an NH 2 group, or a COOH group, or ##STR58## where X is oxygen or sulfur and Z 1 and Z 2 are as defined above, R 3 is hydrogen or a hydroxyl group, and n is an integer between 0 and 10, except that n cannot be 0 if R 3 is OH, or a salt of such compound with an organic or inorganic bases when R 1 =H.