US4745177A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Desulfatohirudins, the preparation thereof and pharmaceutical compositions containing them
Assignee: UCP Gen Pharma AG
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Filing: 1986-11-13
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Granted: 1988-05-17
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Expires: 2006-11-13
Abstract
Abstract The present invention relates to desulfatohirudins, to the preparation thereof, to pharmaceutical compositions containing these compounds, and to the use thereof. The desulfatohirudins of this invention correspond to hirudin in biological activity and are therefore particularly useful for inhibiting blood clotting.
Inventors
- 👤 Hans Fritz
- 👤 Johannes Dodt
- 👤 Ursula Seemuller
- 👤 Ernst Fink
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 14:59
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/81; C07K14/815; A; A61; A61P; A61P7/00; A61P7/02; A61K; A61K38/00; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/26
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
35 words
A desulfatohirudin of the formula I ##STR3## or of the formula II ##STR4## wherein the --Cys-- residues are linked in pairs by disulfide bridges in the same manner as in hirudin, or a salt thereof.
Claim 2
Dependent Claim
35 words
A desulfatohirudin of the formula I ##STR3## or of the formula II ##STR4## wherein the --Cys-- residues are linked in pairs by disulfide bridges in the same manner as in hirudin, or a salt thereof.
Claim 3
Dependent Claim
16 words
The desulfatohirudin according to claim 1 characterised by formula I, or a pharmaceutically acceptable salt thereof.
Claim 4
Dependent Claim
16 words
The desulfatohirudin according to claim 1 characterised by formula II, or a pharmaceutically acceptable salt thereof.
Claim 5
Dependent Claim
28 words
A pharmaceutical composition containing at least one desulfatohirudin according to claim 1, or a pharmacologicallly acceptable salt thereof, optionally together with at least one pharmaceutical carrier or excipient.
References Cited (Backward Citations)
US4668662A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-05-17 | 1991-11-16 | 1992-05-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-05-17 | 1995-11-16 | 1996-05-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-05-17 | 1999-11-16 | 2000-05-17 | $7700.00 | Window Closed / Lapsed |