US4743248A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Dosage form for delivering acid sensitive beneficial agent
Assignee: Alza Corp
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Filing: 1986-08-11
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Granted: 1988-05-10
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Expires: 2006-08-11
Abstract
Abstract A dosage form is disclosed, which dosage form comprises an outside wall and an inside wall, which inside wall comprises means for changing its structural integrity in response to fluid having a pH greater than 5 that enters the dosage form, thereby changing the pH environment inside the dosage form and concomitantly causing the inside wall to change its structural integrity, thus causing the outside wall to collapse and be easily eliminated from a host.
Inventors
- 👤 Marc L. Bartoo
- 👤 Patrick S. L. Wong
- 👤 Felix Theeuwes
- 👤 Brian Barclay
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 18:27
CPC Classifications
A; A61; A61J; A61J3/00; A61M; A61M31/00; A61M31/002; A61K; A61K9/00; A61K9/0002; A61K9/0004; A61K9/20
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
247 words
A dosage form for dispensing a beneficial agent formulation to an environment of use, the dosage form comprising: (a) a first wall that permits the passage of fluid and comprises means for keeping its chemical integrity in a first fluid environment exhibiting a pH less than 5 and for losing its chemical integrity in a second fluid environment exhibiting a pH greater than 5; (b) a second wall that permits the passage of fluid and comprises means for keeping its chemical integrity in a first fluid environment exhibiting a pH less than 5 and for keeping its chemical integrity in a second environment exhibiting a pH greater than 5; (c) a compartment formed by the first wall and the second wall with the first wall surrounding and facing the inside of the compartment and the second wall surrounding the first wall and facing the environment of use; (d) a beneficial agent formulation in the compartment, which agent formulation forms with fluid that enters the compartment a fluid environment exhibiting a pH less than 5; (e) at lease one passageway through the walls for dispensing the beneficial agent formulation from the dosage form to the environment of use over time; and, (f) wherein, fluid from the environment exhibiting a pH greater than 5 enters the dosage form causing the first wall at the end of the dispensing of the beneficial agent to lose its chemical integrity for facilitating discharge of the dosage form from the environment of use.
Claim 2
Dependent Claim
247 words
A dosage form for dispensing a beneficial agent formulation to an environment of use, the dosage form comprising: (a) a first wall that permits the passage of fluid and comprises means for keeping its chemical integrity in a first fluid environment exhibiting a pH less than 5 and for losing its chemical integrity in a second fluid environment exhibiting a pH greater than 5; (b) a second wall that permits the passage of fluid and comprises means for keeping its chemical integrity in a first fluid environment exhibiting a pH less than 5 and for keeping its chemical integrity in a second environment exhibiting a pH greater than 5; (c) a compartment formed by the first wall and the second wall with the first wall surrounding and facing the inside of the compartment and the second wall surrounding the first wall and facing the environment of use; (d) a beneficial agent formulation in the compartment, which agent formulation forms with fluid that enters the compartment a fluid environment exhibiting a pH less than 5; (e) at lease one passageway through the walls for dispensing the beneficial agent formulation from the dosage form to the environment of use over time; and, (f) wherein, fluid from the environment exhibiting a pH greater than 5 enters the dosage form causing the first wall at the end of the dispensing of the beneficial agent to lose its chemical integrity for facilitating discharge of the dosage form from the environment of use.
Claim 3
Dependent Claim
21 words
The dosage form for dispensing the beneficial agent formulation according to claim 1, wherein the second wall contact the first wall.
Claim 4
Dependent Claim
23 words
The dosage form for dispensing the beneficial agent formulation according to claim 1, wherein the beneficial agent is a pharmaceutically acceptable acidic drug.
Claim 5
Dependent Claim
27 words
The dosage form for dispensing the beneficial agent formulation according to claim 1, wherein the beneficial agent is a drug comprising its pharmaceutically acceptable acid addition salt.
Claim 6
Dependent Claim
24 words
The dosage form for dispensing the beneficial agent formulation according to claim 1, wherein the first wall initially is thicker than the second wall.
Claim 7
Dependent Claim
287 words
A dosage form for dispensing a beneficial agent formulation to a biological environment of use, the dosage form comprising: (a) a first wall that pemits the passage of fluid and comprises means for keeping its chemical integrity in a first fluid envirnoment inside the dosage form exhibiting a pH less than 5 and for losing its chemical integrity in a second fluid environment inside the dosage form exhibiting a pH greater than 5; (b) a second wall that permits the passage of fluid and comprises means for keeping its chemical integrity in a first fluid environment exhibiting a pH less than 5 and for keeping its chemical integrity in a second environment exhibiting a pH greater than 5; (c) a compartment formed by the first wall and by the second wall which first wall surrounds and faces the inside of the compartment and which second wall surrounds the first wall and faces the biological environment of use; (d) a beneficial agent formulation in the compartment, which agent formulation forms with fluid that enters the compartment a fluid environment exhibiting a pH less than 5, and a hydrophilic hydrogel formulation in the compartment that aids in dispensing the agent formulation from the dosage form; (e) at least one passageway through the walls connecting the compartment with the biological environment of use for dispensing the beneficial agent formulation from the dosage form over a prolonged period of time; and, (f) wherein fluid from the environment having a pH greater than 5 enters the dosage form through the passageway causing the first wall at the end of the dispensing of the beneficial agent to lose its chemical interity for facilitating discharge of the dosage form from the environment of use.
Claim 8
Dependent Claim
287 words
A dosage form for dispensing a beneficial agent formulation to a biological environment of use, the dosage form comprising: (a) a first wall that pemits the passage of fluid and comprises means for keeping its chemical integrity in a first fluid envirnoment inside the dosage form exhibiting a pH less than 5 and for losing its chemical integrity in a second fluid environment inside the dosage form exhibiting a pH greater than 5; (b) a second wall that permits the passage of fluid and comprises means for keeping its chemical integrity in a first fluid environment exhibiting a pH less than 5 and for keeping its chemical integrity in a second environment exhibiting a pH greater than 5; (c) a compartment formed by the first wall and by the second wall which first wall surrounds and faces the inside of the compartment and which second wall surrounds the first wall and faces the biological environment of use; (d) a beneficial agent formulation in the compartment, which agent formulation forms with fluid that enters the compartment a fluid environment exhibiting a pH less than 5, and a hydrophilic hydrogel formulation in the compartment that aids in dispensing the agent formulation from the dosage form; (e) at least one passageway through the walls connecting the compartment with the biological environment of use for dispensing the beneficial agent formulation from the dosage form over a prolonged period of time; and, (f) wherein fluid from the environment having a pH greater than 5 enters the dosage form through the passageway causing the first wall at the end of the dispensing of the beneficial agent to lose its chemical interity for facilitating discharge of the dosage form from the environment of use.
Claim 9
Dependent Claim
21 words
The dosage form for dispensing the beneficial agen formulation according to claim 6, wherein the second wall contacts the first wall.
Claim 10
Dependent Claim
23 words
The dosage form for dispensing the beneficial agent formulation according to claim 6, wherein the beneficial agent is a pharmaceutically acceptable acidic drug.
Claim 11
Dependent Claim
27 words
The dosage form for dispensing the beneficial agent formulation according to claim 6, wherein the beneficial agent is a drug comprising its pharmaceutically acceptable acid addition salt.
Claim 12
Dependent Claim
24 words
The dosage form for dispensing the beneficial agent formulation according to claim 6, wherein the first wall initially is thicker than the second wall.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-05-10 | 1991-11-09 | 1992-05-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-05-10 | 1995-11-09 | 1996-05-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-05-10 | 1999-11-09 | 2000-05-10 | $7700.00 | Window Closed / Lapsed |