US4742157A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Substantially pure rheumatoid arthritis specific protein and an antibody against the same
Assignee: Medecs Co Ltd
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Filing: 1985-09-13
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Granted: 1988-05-03
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Expires: 2005-09-13
Abstract
Abstract A substantially pure rheumatoid arthritis specific protein (RASP) and an antibody against the rheumatoid arthritis specific protein (anti-RASP antibody) are disclosed. The RASP is found specifically in the serum or plasma of a patient suffering from rheumatoid arthritis, and may be detected using an anti-RASP antibody easily and effectively. Therefore, the anti-RASP antibody of the present invention is useful for the diagnosis of rheumatoid arthritis by the criterion of the presence of RASP.
Inventors
- 👤 Naoki Yamanaka
- 👤 Makoto Yoshida
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 11:10
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/564; C; C07; C07K; C07K14/00; C07K14/435; C07K14/46; C07K14/47; C07K14/4701; C07K14/4713; C07K16/00; C07K16/18; G01N2800/00; G01N2800/10; G01N2800/101; G01N2800/102; Y; Y10; Y10S; Y10S436/00; Y10S436/804; Y10S436/811; Y10S530/00; Y10S530/806; Y10S530/808; Y10S530/868
Claims Analysis
Total Claims: 2
Claim 1
Independent Claim
164 words
A substantially pure rheumatoid arthritis specific protein which comprises light peptide chains and heavy peptide chains, said light peptide chains each having a molecular weight of about 25,000 to 30,000 in terms of a value as measured by an SDS-polyacrylamide gel electrophoresis method as defined herein, said heavy peptide chains each having a molecular weight of about 55,000 to 60,000 in terms of a value as measured by as SDS-polyacrylamide gel electrophoresis method as defined herein; and which protein has: (1) a molecular weight of about 150,000 to 170,000 in terms of a value as measured by an SDS-polyacrylamide gel electrophoresis method as defined herein; (2) an isoelectric point of about 7.3 to 7.8 in terms of a value as measured by a two-dimensional electrophoresis method as defined herein; (3) an electrophoretic mobility of about 0.30 to 0.45 in terms of a value as measured by a two-dimensional electrophoresis method as defined herein; and (4) an antigenic determinant common to that of human IgG.
Claim 2
Dependent Claim
164 words
A substantially pure rheumatoid arthritis specific protein which comprises light peptide chains and heavy peptide chains, said light peptide chains each having a molecular weight of about 25,000 to 30,000 in terms of a value as measured by an SDS-polyacrylamide gel electrophoresis method as defined herein, said heavy peptide chains each having a molecular weight of about 55,000 to 60,000 in terms of a value as measured by as SDS-polyacrylamide gel electrophoresis method as defined herein; and which protein has: (1) a molecular weight of about 150,000 to 170,000 in terms of a value as measured by an SDS-polyacrylamide gel electrophoresis method as defined herein; (2) an isoelectric point of about 7.3 to 7.8 in terms of a value as measured by a two-dimensional electrophoresis method as defined herein; (3) an electrophoretic mobility of about 0.30 to 0.45 in terms of a value as measured by a two-dimensional electrophoresis method as defined herein; and (4) an antigenic determinant common to that of human IgG.
References Cited (Backward Citations)
JPS59180363A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-05-03 | 1991-11-02 | 1992-05-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-05-03 | 1995-11-02 | 1996-05-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-05-03 | 1999-11-02 | 2000-05-03 | $7700.00 | Window Closed / Lapsed |