US4731474A
Expired / Lapsed
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Novel therapeutic compounds useful as hypolipidemic and hypocholesteremic agents
Assignee: Council of Scientific and Industrial Research
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Filing: 1986-01-17
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Granted: 1988-03-15
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Expires: 2006-01-17
Abstract
Abstract The present invention relates to novel therapeutic compounds useful as hypolipidemic and hypocholesteremic agents and to a process for the preparation of such compounds. More particularly, the present invention relates to novel alkali metal salts of substituted α-(3-pentadecylphenoxy)-isobutyric acid, which have never been reported in the prior art and which have now been synthesized for the first time, and to a process for the preparation thereof.
Inventors
- 👤 Thallapalli Ramalingam
- 👤 Yadavalli V. D. Nageswar
- 👤 Maddamsetty V. Rao
- 👤 Pralhad B. Sattur
- 👤 Gopalakrishna Thyagarajan
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 01:24
CPC Classifications
C; C07; C07C; C07C59/00; C07C59/40; C07C59/58; C07C59/64; C07C59/66; C07C59/68; A; A61; A61P; A61P3/00; A61P3/06
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
28 words
Alkali metal salts of substituted α-(3-pentadecyl-phenoxy)-isobutyric acid of the general formula: ##STR4## wherein R is a halogen, M is an alkali metal and x is 1 or 2.
Claim 2
Dependent Claim
28 words
Alkali metal salts of substituted α-(3-pentadecyl-phenoxy)-isobutyric acid of the general formula: ##STR4## wherein R is a halogen, M is an alkali metal and x is 1 or 2.
Claim 3
Independent Claim
57 words
A method for decreasing blood lipids comprising administering to a patient in need of a hypolipidemic, an effective amount of a composition comprising alkali metal salts of substituted α-(3-pentadecylphenoxy)-isobutyric acid of the general formula: ##STR5## wherein R is hydrogen or halogen, M is an alkali metal and x is 1 or 2, and a pharmaceutically acceptable vehicle.
Claim 4
Independent Claim
57 words
A method for decreasing blood lipids comprising administering to a patient in need of a hypolipidemic, an effective amount of a composition comprising alkali metal salts of substituted α-(3-pentadecylphenoxy)-isobutyric acid of the general formula: ##STR5## wherein R is hydrogen or halogen, M is an alkali metal and x is 1 or 2, and a pharmaceutically acceptable vehicle.
Claim 5
Dependent Claim
18 words
A method, as in claim 2, wherein said alkali metal salt of substituted α-(3-pentadecylphenoxy)isobutyl acid comprises sodium α-(3-pentadecylphenoxy)-isobutyrate.
Claim 6
Dependent Claim
18 words
A method, as in claim 2, wherein said alkali metal salt of substituted α-(3-pentadecylphenoxy)isobutyl acid comprises magnesium α-(3-pentadecylphenoxy)-isobutyrate.
Claim 7
Dependent Claim
14 words
A method, as in claim 2, wherein said blood lipids comprise cholesterol and triglycerides.
Claim 8
Dependent Claim
16 words
A method, as in claim 2, wherein said effective amount comprises 200 mg/kg of body weight.
Claim 9
Dependent Claim
12 words
A method, as in claim 5, wherein M is calcium and x=2.
Claim 10
Dependent Claim
11 words
A method, as in claim 7, wherein R is a halogen.
Claim 11
Dependent Claim
10 words
A method, as in claim 7, wherein R is chlorine.
Claim 12
Dependent Claim
10 words
A compound, as in claim 1, wherein R is chlorine.
Claim 13
Dependent Claim
12 words
A compound, as in claim 1, wherein M is calcium and x=2.
Claim 14
Dependent Claim
10 words
A compound, as in claim 1, wherein M is calcium.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-03-15 | 1991-09-14 | 1992-03-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-03-15 | 1995-09-14 | 1996-03-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-03-15 | 1999-09-14 | 2000-03-15 | $7700.00 | Window Closed / Lapsed |