Quinoline antibacterial compounds

Claim 1

A compound having the formula: ##STR75## wherein R 1 is hydrogen or a carboxy protecting group; R is selected from the group consisting of (1) an aromatic heterocyclic ring having 5 to 6 atoms therein, with 1 to 2 hetero atoms being selected from the group consisting of S, O and N and the remaining atoms in the ring being carbon atoms and substituted derivatives of said aromatic heterocyclic ring wherein the aromatic heterocyclic ring is mono-substituted with C 1 to C 6 alkyl; and (2) a phenyl group having the formula: ##STR76## wherein R 2 is one, two or three substituents independently selected from the group consisting of hydrogen, halogen, cyano, C 1 to C 6 alkyl, halo-substituted C 1 to C 6 alkyl, a group having the formula: --Y--R.sub.3 wherein --Y-- is --O-- or --S-- or R 3 is hydrogen or C 1 to C 6 alkyl, and NH 2 ; and Z is selected from the group consisting of (1) an aliphatic heterocyclic ring having the structure: ##STR77## wherein R 8 is CH 2 , (CH 2 ) 2 or a group of the formula --(CH 2 ) n --R 9 -- wherein R 9 is --N--, --O--, or --S-- and n is 0, 1 or 2, and substituted derivatives thereof wherein the aliphatic heterocyclic ring is substituted with one, two or three substituents independently selected from the group consisting of C 1 to C 6 alkyl, C 1 to C 3 alkylamino-substituted C 1 to C 6 alkyl, amino-substituted C 1 to C 6 alkyl, hydroxy, alkanoyl having 1 to 6 carbon atoms, alkanoylamido having 1 to 6 carbon atoms, halogen, an amine of the formula: ##STR78## wherein R 10 and R 11 are each independently selected from the group consisting of hydrogen and C 1 to C 6 alkyl; and (2) an amino group of the formula: ##STR79## wherein R 6 is hydrogen or C 1 to C 6 alkyl, and R 7 is selected from the group consisting of C 1 to C 6 alkyl, NH 2 , a mono-(C 1 to C 4 ) alkylamino group and a di-(C 1 to C 4 ) alkylamino group, and pharmaceutically acceptable salts thereof.