US4728661A
Expired / Lapsed
US
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Cardiotonic phenyl oxazolones
Assignee: Aventis Pharmaceuticals Inc
•
Filing: 1985-11-13
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Granted: 1988-03-01
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Expires: 2005-11-13
Abstract
Abstract Phenyloxazolones are useful as cardiotonics in the treatment of heart failure and enhance cardiac function.
Inventors
- 👤 Richard A. Schnettler
- 👤 Winton D. Jones, Jr.
- 👤 George P. Claxton
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 20:17
CPC Classifications
C; C07; C07D; C07D231/00; C07D231/02; C07D231/10; C07D231/12; A; A61; A61P; A61P9/00; A61P9/04; C07D233/00; C07D233/54; C07D233/56; C07D249/00; C07D249/02; C07D249/08; C07D263/00; C07D263/02; C07D263/30; C07D263/34; C07D263/36; C07D263/38; C07D263/46
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
117 words
A method of treating heart failure in a patient in need thereof which comprises administering to the patient a cardiotonically effective amount of a phenyl oxazolone of the formula ##STR6## wherein Y is an oxygen or sulfur group; and R 1 is a hydrogen, or a (C 1 -C 5 )alkyl group, R 2 is a phenyl group optionally substituted with one or two members of the group consisting of (C 1 -C 5 )alkyl, (C 1 -C 5 )alkoxy, (C 1 -C 5 )alkylthio, (C 1 -C 5 )alkylsulfinyl, (C 1 -C 5 )alkylsulfonyl, hydroxy, halogen, cyano, carboxy, carb(C 1 -C 5 )alkoxy, carbamido, (C 1 -C 5 )alkanoylamino, imidazolyl, trifluoromethyl or with a methylenedioxy group.
Claim 2
Independent Claim
117 words
A method of treating heart failure in a patient in need thereof which comprises administering to the patient a cardiotonically effective amount of a phenyl oxazolone of the formula ##STR6## wherein Y is an oxygen or sulfur group; and R 1 is a hydrogen, or a (C 1 -C 5 )alkyl group, R 2 is a phenyl group optionally substituted with one or two members of the group consisting of (C 1 -C 5 )alkyl, (C 1 -C 5 )alkoxy, (C 1 -C 5 )alkylthio, (C 1 -C 5 )alkylsulfinyl, (C 1 -C 5 )alkylsulfonyl, hydroxy, halogen, cyano, carboxy, carb(C 1 -C 5 )alkoxy, carbamido, (C 1 -C 5 )alkanoylamino, imidazolyl, trifluoromethyl or with a methylenedioxy group.
Claim 3
Dependent Claim
11 words
A method of claim 1 wherein Y is an oxygen group.
Claim 4
Dependent Claim
16 words
A method of claim 2 wherein R 1 is a (C 1 -C 5 )alkyl group.
Claim 5
Dependent Claim
13 words
A method of claim 2 wherein R 2 is an unsubstituted phenyl group.
Claim 6
Dependent Claim
13 words
A method of claim 3 wherein R 2 is a substituted phenyl group.
Claim 7
Dependent Claim
15 words
A method of claim 2 wherein R 1 is a methyl, ethyl or propyl group.
Claim 8
Dependent Claim
13 words
A method of claim 6 wherein R 2 is a substituted phenyl group.
Claim 9
Independent Claim
116 words
A method of enhancing myocardial contractile function in a patient in need thereof which comprises administering to the patient an effective amount of phenyl oxazolone of the formula ##STR7## wherein Y is an oxygen or sulfur group; and R 1 is a hydrogen, or a (C 1 -C 5 )alkyl group, R 2 is a phenyl group optionally substituted with one or two members of the group consisting of (C 1 -C 5 )alkyl, (C 1 -C 5 )alkoxy, (C 1 -C 5 )alkylthio, (C 1 -C 5 )alkylsulfinyl, (C 1 -C 5 )alkylsulfonyl, hydroxy, halogen, cyano, carboxy, carb(C 1 -C 5 )alkoxy, carbamido, (C 1 -C 5 )alkanoylamino, imidazolyl, trifluoromethyl or with a methylenedioxy group.
Claim 10
Independent Claim
116 words
A method of enhancing myocardial contractile function in a patient in need thereof which comprises administering to the patient an effective amount of phenyl oxazolone of the formula ##STR7## wherein Y is an oxygen or sulfur group; and R 1 is a hydrogen, or a (C 1 -C 5 )alkyl group, R 2 is a phenyl group optionally substituted with one or two members of the group consisting of (C 1 -C 5 )alkyl, (C 1 -C 5 )alkoxy, (C 1 -C 5 )alkylthio, (C 1 -C 5 )alkylsulfinyl, (C 1 -C 5 )alkylsulfonyl, hydroxy, halogen, cyano, carboxy, carb(C 1 -C 5 )alkoxy, carbamido, (C 1 -C 5 )alkanoylamino, imidazolyl, trifluoromethyl or with a methylenedioxy group.
Claim 11
Dependent Claim
11 words
A method of claim 8 wherein Y is an oxygen group.
Claim 12
Dependent Claim
16 words
A method of claim 9 wherein R 1 is a (C 1 -C 5 )alkyl group.
Claim 13
Dependent Claim
13 words
A method of claim 9 wherein R 2 is an unsubstituted phenyl group.
Claim 14
Dependent Claim
13 words
A method of claim 10 wherein R 2 is a substituted phenyl group.
Claim 15
Dependent Claim
15 words
A method of claim 10 wherein R 1 is a methyl, ethyl or propyl group.
Claim 16
Dependent Claim
13 words
A method of claim 13 wherein R 2 is a substituted phenyl group.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1991-03-01 | 1991-08-31 | 1992-03-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-03-01 | 1995-08-31 | 1996-03-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-03-01 | 1999-08-31 | 2000-03-01 | $7700.00 | Window Closed / Lapsed |