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US4725686A
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Benzodiazinone-pyridazinone and hydroxy-pyrazolyl compounds, cardiotonic compositions including the same, and their uses
Assignee: WILLIAM RORER Inc A CORP OF
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Filing: 1985-11-22
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Granted: 1988-02-16
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Expires: 2005-11-22
Abstract
Abstract A method for increasing cardiotonic contractility in humans or other animals using a class of benzodiazinonepryidazinone and hydroxy-pyrazolyl compounds and pharmaceutical compositions including the same.
Inventors
- 👤 Donald E. Kuhla
- 👤 Henry F. Campbell
- 👤 William L. Studt
- 👤 William C. Faith
- 👤 Bruce F. Molino
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 22:43
CPC Classifications
C; C07; C07D; C07D403/00; C07D403/02; C07D403/04
Claims Analysis
Total Claims: 31
Claim 1
Independent Claim
86 words
A compound of the formula ##STR22## wherein: x is 1; Y is ##STR23## R 1 , R 2 , R 3 , R 4 and R 6 are each independently H, alkyl or aralkyl; R and R 5 are H or alkyl; R groups on vicinal carbon atoms may together form a carbon-carbon double bond; and geminal R 4 and R 5 groups may together form a spiro substituent, --(CH 2 ) d --, where d is 2 to 5; or a pharmaceutically acceptable salt thereof.
Claim 2
Dependent Claim
86 words
A compound of the formula ##STR22## wherein: x is 1; Y is ##STR23## R 1 , R 2 , R 3 , R 4 and R 6 are each independently H, alkyl or aralkyl; R and R 5 are H or alkyl; R groups on vicinal carbon atoms may together form a carbon-carbon double bond; and geminal R 4 and R 5 groups may together form a spiro substituent, --(CH 2 ) d --, where d is 2 to 5; or a pharmaceutically acceptable salt thereof.
Claim 3
Dependent Claim
94 words
A compound of the formula ##STR24## wherein: x is 1; Y is ##STR25## a is 1 or 2; R 1 , R 2 , R 3 , R 4 and R 6 are each independently H, alkyl or aralkyl; R and R 5 are H or alkyl; R or R 5 groups on vicinal carbon atoms may together form a carbon-carbon double bond; and geminal R 4 and R 5 groups may together form a spiro substituent, --(CH 2 ) d --, where d is 2 to 5; or a pharmaceutically acceptable salt thereof.
Claim 4
Dependent Claim
94 words
A compound of the formula ##STR24## wherein: x is 1; Y is ##STR25## a is 1 or 2; R 1 , R 2 , R 3 , R 4 and R 6 are each independently H, alkyl or aralkyl; R and R 5 are H or alkyl; R or R 5 groups on vicinal carbon atoms may together form a carbon-carbon double bond; and geminal R 4 and R 5 groups may together form a spiro substituent, --(CH 2 ) d --, where d is 2 to 5; or a pharmaceutically acceptable salt thereof.
Claim 5
Dependent Claim
18 words
A compound according to claim 1 wherein: R, R 1 , R 2 and R 5 are hydrogen.
Claim 6
Dependent Claim
19 words
A compound according to claim 1 wherein: R 3 , R 4 and R 5 are hydrogen or alkyl.
Claim 7
Dependent Claim
10 words
A compound according to claim 2 wherein: a is 1.
Claim 8
Dependent Claim
17 words
A compound according to claim 1 wherein: R 1 , R 2 and R 5 are hydrogen.
Claim 9
Dependent Claim
21 words
A compound according to claim 1 wherein: R, R 3 , R 4 , R 5 and R 6 are hydrogen.
Claim 10
Dependent Claim
16 words
A compound according to claim 1 wherein: vicinal R groups together form a carbon-carbon double bond.
Claim 11
Dependent Claim
94 words
A compound of the formula ##STR26## wherein: x is 1; Y is ##STR27## b is 1 or 2; R 1 , R 2 , R 3 , R 4 and R 6 are each independently H, alkyl or aralkyl; R and R 5 are H or alkyl; R or R 5 groups on vicinal carbon atoms may together form a carbon-carbon double bond; and geminal R 4 and R 5 groups may together form a spiro substituent, --(CH 2 ) d --, where d is 2 to 5; or a pharmaceutically acceptable salt thereof.
Claim 12
Dependent Claim
94 words
A compound of the formula ##STR26## wherein: x is 1; Y is ##STR27## b is 1 or 2; R 1 , R 2 , R 3 , R 4 and R 6 are each independently H, alkyl or aralkyl; R and R 5 are H or alkyl; R or R 5 groups on vicinal carbon atoms may together form a carbon-carbon double bond; and geminal R 4 and R 5 groups may together form a spiro substituent, --(CH 2 ) d --, where d is 2 to 5; or a pharmaceutically acceptable salt thereof.
Claim 13
Dependent Claim
18 words
A compound according to claim 9 wherein: R, R 1 , R 2 and R 5 are hydrogen.
Claim 14
Dependent Claim
18 words
A compound according to claim 5 wherein: R, R 1 , R 2 and R 5 are hydrogen.
Claim 15
Dependent Claim
19 words
A compound according to claim 5 wherein: R 3 , R 4 and R 5 are hydrogen or alkyl.
Claim 16
Dependent Claim
17 words
A compound according to claim 5 wherein: R 1 , R 2 and R 5 are hydrogen.
Claim 17
Dependent Claim
21 words
A compound according to claim 5 wherein: R, R 3 , R 4 , R 5 and R 6 are hydrogen.
Claim 18
Dependent Claim
16 words
A compound according to claim 5 wherein: vicinal R groups together form a carbon-carbon double bond.
Claim 19
Dependent Claim
19 words
A compound according to claim 9 wherein: R 3 , R 4 and R 5 are hydrogen or alkyl.
Claim 20
Dependent Claim
10 words
A compound according to claim 2 wherein: a is 2.
Claim 21
Dependent Claim
15 words
A compound according to claim 2 which is 3,4-dihydro-6-[3-(4,5-dihydro-pyridizin-6-one)]-2(1H)-quinazolinone, or a pharmaceutically acceptable salt thereof.
Claim 22
Dependent Claim
17 words
A compound according to claim 9 wherein: R 1 , R 2 and R 5 are hydrogen.
Claim 23
Dependent Claim
15 words
A compound according to claim 2 which is 3,4-dihydro-6-[3-(4,5-dihydro-4-methyl-pyridizin-6-one)]-2(1H)-quinazolinone, or a pharmaceutically acceptable salt thereof.
Claim 24
Dependent Claim
15 words
A compound according to claim 2 which is 3,4-dihydro-6-[3-(4,5-dihydro-pyrizidin-6-one)]-1-methyl-2(1H)-quinazolinone, or a pharmaceutically acceptable salt thereof.
Claim 25
Dependent Claim
15 words
A compound according to claim 2 which is 3,4-dihydro-6-[3-(4,5-dihydro-4-methyl-pyrizidin-6-one)]-1-methyl-2(1H)-quinazolinone, or a pharmaceutically acceptable salt thereof.
Claim 26
Dependent Claim
15 words
A compound according to claim 2 which is 3,4-dihydro-6-[3-(4,5-dihydro-pyridizin-6-one)]-3-methyl-2(1H)-quinazolinone, or a pharmaceutically acceptable salt thereof.
Claim 27
Dependent Claim
15 words
A compound according to claim 2 which is 3,4-dihydro-6-[3-(4,5-dihydro-4-methyl-pyrizidin-6-one)]-3methyl-2(1H)-quinazolinone, or a pharmaceutically acceptable salt thereof.
Claim 28
Dependent Claim
15 words
A compound according to claim 2 which is 3,4-dihydro-6-[3-(4,5-dihydro-pyridizin-6-one)]-2(1H)-4-methyl-quinazolinone, or a pharmaceutically acceptable salt thereof.
Claim 29
Dependent Claim
15 words
A compound according to claim 2 which is 3,4-dihydro-6-[3-(4,5-dihydro-4-methyl-pyridizin-6-one)]-4-methyl-2(1H)-quinazolinone, or a pharmaceutically acceptable salt thereof.
Claim 30
Dependent Claim
21 words
A compound according to claim 9 wherein: R, R 3 , R 4 , R 5 and R 6 are hydrogen.
Claim 31
Dependent Claim
16 words
A compound according to claim 9 wherein: vicinal R groups together form a carbon-carbon double bond.
References Cited (Backward Citations)
US4026891A
Cited
US4361563A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1991-02-15 | 1991-08-17 | 1992-02-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-02-15 | 1995-08-17 | 1996-02-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-02-15 | 1999-08-17 | 2000-02-16 | $7700.00 | Window Closed / Lapsed |