US4720490A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Fluoralkylatedcarbapenem derivatives
Assignee: FIRST NATIONAL STATE BANK NEWARK NEW JERSEY
•
Filing: 1985-10-30
•
Granted: 1988-01-19
•
Expires: 2005-10-30
Abstract
Abstract 6-(1'-fluorethyl)- and 6-(1'-fluoro-1'-methylethyl)-carbapenems such as (5RS,6RS)-1-aza-6-(1(RS)-fluorethyl)-3-(N'-dimethyl-N'-methylamidinome thylthio)-7-oxobicyclo[3.2.0]hept-2-ene-2-carboxylic acid which are useful as chemotherapeutic agents in particular as anti-bacterially active anti-biotics.
Inventors
- 👤 Ching P. Mak
- 👤 Hans Fliri
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 11:30
CPC Classifications
C; C07; C07D; C07D477/00; C07D477/10; C07D477/12; C07D477/16; C07D477/20; C07D205/00; C07D205/02; C07D205/06; C07D205/08; C07D499/00; C07D499/88; C07F; C07F7/00; C07F7/02; C07F7/08; C07F7/10
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
115 words
A compound of the formula ##STR37## wherein R 1 is hydrogen or methyl, and R 2 is a substituent of the formula ##STR38## wherein R 4 , R 5 and R 6 are the same or different and are hydrogen or lower alkyl or R 4 and R 5 are joined to form a ring in II and IIa, which rings are unsubstituted or mono- or poly-substituted by alkyl, hydroxy, carboxy or di-(lower)-alkylamino, m is 2 or 3, and n is 1, 2 or 3 or a salt thereof or a zwitterion thereof, with the proviso that when R 1 is hydrogen and the group containing it has R- configuration, R 2 is not acetylaminoethyl.
Claim 2
Dependent Claim
115 words
A compound of the formula ##STR37## wherein R 1 is hydrogen or methyl, and R 2 is a substituent of the formula ##STR38## wherein R 4 , R 5 and R 6 are the same or different and are hydrogen or lower alkyl or R 4 and R 5 are joined to form a ring in II and IIa, which rings are unsubstituted or mono- or poly-substituted by alkyl, hydroxy, carboxy or di-(lower)-alkylamino, m is 2 or 3, and n is 1, 2 or 3 or a salt thereof or a zwitterion thereof, with the proviso that when R 1 is hydrogen and the group containing it has R- configuration, R 2 is not acetylaminoethyl.
Claim 3
Dependent Claim
33 words
A compound according to claim 1 selected from the group consisting of ##STR39## or a protected form thereof and/or a physiologically-hydrolyzable and acceptable ester thereof, or a salt thereof or a zwitterion thereof.
Claim 4
Dependent Claim
31 words
An antimicrobial composition comprising an effective amount of a compound as claimed in claim 1 or a pharmaceutically acceptable salt or zwitterion thereof together with a pharmaceutically acceptable diluent or carrier.
Claim 5
Dependent Claim
31 words
An antimicrobial composition comprising an effective amount of a compound as claimed in claim 2 or a pharmaceutically acceptable salt or zwitterion thereof together with a pharmaceutically acceptable diluent or carrier.
Claim 6
Dependent Claim
43 words
A method of combating bacteria which comprises administering to a subject in need of such treatment an effective amount of a compound as claimed in claim 1 or a pharmaceutically acceptable salt or zwitterion thereof together with a pharmaceutically acceptable diluent or carrier.
Claim 7
Dependent Claim
43 words
A method of combating bacteria which comprises administering to a subject in need of such treatment an effective amount of a compound as claimed in claim 2 or a pharmaceutically acceptable salt or zwitterion thereof together with a pharmaceutically acceptable diluent or carrier.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-01-18 | 1991-07-20 | 1992-01-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-01-18 | 1995-07-20 | 1996-01-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-01-18 | 1999-07-20 | 2000-01-19 | $7700.00 | Window Closed / Lapsed |